Peroxisome proliferator-activated receptor β stimulation induces rapid cardiac growth and angiogenesis via direct activation of calcineurin

Aims Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors. PPARβ agonists were suggested as potential drugs for the treatment of metabolic syndrome, but effects of PPARβ activation on cardiac growth and vascularization are unknown. Thus, we investigated the...

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Veröffentlicht in:	Cardiovascular research 2009-07, Vol.83 (1), p.61-71
Hauptverfasser:	Wagner, Nicole, Jehl-Piétri, Chantal, Lopez, Pascal, Murdaca, Joseph, Giordano, Christian, Schwartz, Chantal, Gounon, Pierre, Hatem, Stéphane N., Grimaldi, Paul, Wagner, Kay-Dietrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Biological and medical sciences Calcineurin Calcineurin - metabolism Calcineurin Inhibitors Cardiology. Vascular system Cells, Cultured Coronary Vessels - cytology Coronary Vessels - drug effects Coronary Vessels - metabolism Cyclin-Dependent Kinase 9 - metabolism Cyclosporine - pharmacology Enzyme Inhibitors - pharmacology Gene transcription Heart - drug effects Heart - growth & development Hypertrophy Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Male Medical sciences Mice Mice, Inbred C57BL Models, Animal Myocardium - cytology Myocardium - metabolism Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Neovascularization, Physiologic - drug effects NFATC Transcription Factors - metabolism Peroxisome proliferator-activated receptor PPAR-beta - agonists PPAR-beta - pharmacology Thiazoles - pharmacology
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