Resistance to Dual Nucleoside Reverse-Transcriptase Inhibitors in Children Infected with HIV Clade A/E
The prevalence of nucleoside reverse-transcriptase inhibitor (NRTI) mutations was determined among 95 human immunodeficiency virus-infected Thai children who were treated with dual nucleoside reverse-transcriptase inhibitors. Almost all children had resistance to at least 1 NRTI, and approximately h...
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| Veröffentlicht in: | Clinical infectious diseases 2005-01, Vol.40 (2), p.309-312 |
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| creator | Lolekha, Rangsima Sirivichayakul, Sunee Siangphoe, Umaporn Pancharoen, Chitsanu Kaewchana, Suchada Apateerapong, Wichitra Mahanontharit, Apicha Chotpitayasunondh, Tawee Ruxrungtham, Kiat Phanuphak, Praphan Ananworanich, Jintanat |
| description | The prevalence of nucleoside reverse-transcriptase inhibitor (NRTI) mutations was determined among 95 human immunodeficiency virus-infected Thai children who were treated with dual nucleoside reverse-transcriptase inhibitors. Almost all children had resistance to at least 1 NRTI, and approximately half of the children had resistance to multiple NRTIs. Cross-resistance to stavudine and azidothymidine was universal. |
| doi_str_mv | 10.1086/427026 |
| format | Article |
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Almost all children had resistance to at least 1 NRTI, and approximately half of the children had resistance to multiple NRTIs. Cross-resistance to stavudine and azidothymidine was universal.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/427026</identifier><identifier>PMID: 15655753</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>AIDS ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiretrovirals ; Antiviral agents ; Biological and medical sciences ; Child ; Child, Preschool ; Children ; Cross resistance ; Cross-Sectional Studies ; Drug resistance ; Drug Resistance, Multiple, Viral - drug effects ; Female ; Genetic mutation ; HIV ; HIV 1 ; HIV Infections - drug therapy ; HIV Infections - virology ; HIV-1 - classification ; HIV-1 - drug effects ; HIV-1 - genetics ; HIV-1 - physiology ; HIV/AIDS ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infections ; Infectious diseases ; Male ; Medical sciences ; Mutation ; Nucleosides ; Pediatrics ; Pharmacology. Drug treatments ; Reverse transcriptase inhibitors ; Reverse Transcriptase Inhibitors - pharmacology ; Reverse Transcriptase Inhibitors - therapeutic use ; RNA ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>Clinical infectious diseases, 2005-01, Vol.40 (2), p.309-312</ispartof><rights>Copyright 2005 The Infectious Diseases Society of America</rights><rights>2005 by the Infectious Diseases Society of America 2005</rights><rights>2005 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Jan 15, 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-31c86c927893c7a808bd15fc288d33870a1ec5c146a578602a0f0c3159b2c34b3</citedby><cites>FETCH-LOGICAL-c482t-31c86c927893c7a808bd15fc288d33870a1ec5c146a578602a0f0c3159b2c34b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4484063$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4484063$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,777,781,800,27905,27906,57998,58231</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16535401$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15655753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lolekha, Rangsima</creatorcontrib><creatorcontrib>Sirivichayakul, Sunee</creatorcontrib><creatorcontrib>Siangphoe, Umaporn</creatorcontrib><creatorcontrib>Pancharoen, Chitsanu</creatorcontrib><creatorcontrib>Kaewchana, Suchada</creatorcontrib><creatorcontrib>Apateerapong, Wichitra</creatorcontrib><creatorcontrib>Mahanontharit, Apicha</creatorcontrib><creatorcontrib>Chotpitayasunondh, Tawee</creatorcontrib><creatorcontrib>Ruxrungtham, Kiat</creatorcontrib><creatorcontrib>Phanuphak, Praphan</creatorcontrib><creatorcontrib>Ananworanich, Jintanat</creatorcontrib><title>Resistance to Dual Nucleoside Reverse-Transcriptase Inhibitors in Children Infected with HIV Clade A/E</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><addtitle>Clinical Infectious Diseases</addtitle><description>The prevalence of nucleoside reverse-transcriptase inhibitor (NRTI) mutations was determined among 95 human immunodeficiency virus-infected Thai children who were treated with dual nucleoside reverse-transcriptase inhibitors. Almost all children had resistance to at least 1 NRTI, and approximately half of the children had resistance to multiple NRTIs. Cross-resistance to stavudine and azidothymidine was universal.</description><subject>AIDS</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiretrovirals</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Cross resistance</subject><subject>Cross-Sectional Studies</subject><subject>Drug resistance</subject><subject>Drug Resistance, Multiple, Viral - drug effects</subject><subject>Female</subject><subject>Genetic mutation</subject><subject>HIV</subject><subject>HIV 1</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - classification</subject><subject>HIV-1 - drug effects</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - physiology</subject><subject>HIV/AIDS</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mutation</subject><subject>Nucleosides</subject><subject>Pediatrics</subject><subject>Pharmacology. Drug treatments</subject><subject>Reverse transcriptase inhibitors</subject><subject>Reverse Transcriptase Inhibitors - pharmacology</subject><subject>Reverse Transcriptase Inhibitors - therapeutic use</subject><subject>RNA</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Antiretrovirals</topic><topic>Antiviral agents</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Cross resistance</topic><topic>Cross-Sectional Studies</topic><topic>Drug resistance</topic><topic>Drug Resistance, Multiple, Viral - drug effects</topic><topic>Female</topic><topic>Genetic mutation</topic><topic>HIV</topic><topic>HIV 1</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - classification</topic><topic>HIV-1 - drug effects</topic><topic>HIV-1 - genetics</topic><topic>HIV-1 - physiology</topic><topic>HIV/AIDS</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mutation</topic><topic>Nucleosides</topic><topic>Pediatrics</topic><topic>Pharmacology. Drug treatments</topic><topic>Reverse transcriptase inhibitors</topic><topic>Reverse Transcriptase Inhibitors - pharmacology</topic><topic>Reverse Transcriptase Inhibitors - therapeutic use</topic><topic>RNA</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. 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Almost all children had resistance to at least 1 NRTI, and approximately half of the children had resistance to multiple NRTIs. Cross-resistance to stavudine and azidothymidine was universal.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>15655753</pmid><doi>10.1086/427026</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical infectious diseases, 2005-01, Vol.40 (2), p.309-312 |
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| source | MEDLINE; Oxford University Press Journals; JSTOR; EZB Electronic Journals Library |
| subjects | AIDS Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretrovirals Antiviral agents Biological and medical sciences Child Child, Preschool Children Cross resistance Cross-Sectional Studies Drug resistance Drug Resistance, Multiple, Viral - drug effects Female Genetic mutation HIV HIV 1 HIV Infections - drug therapy HIV Infections - virology HIV-1 - classification HIV-1 - drug effects HIV-1 - genetics HIV-1 - physiology HIV/AIDS Human immunodeficiency virus Human viral diseases Humans Infections Infectious diseases Male Medical sciences Mutation Nucleosides Pediatrics Pharmacology. Drug treatments Reverse transcriptase inhibitors Reverse Transcriptase Inhibitors - pharmacology Reverse Transcriptase Inhibitors - therapeutic use RNA Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Resistance to Dual Nucleoside Reverse-Transcriptase Inhibitors in Children Infected with HIV Clade A/E |
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