Resistance to Dual Nucleoside Reverse-Transcriptase Inhibitors in Children Infected with HIV Clade A/E

The prevalence of nucleoside reverse-transcriptase inhibitor (NRTI) mutations was determined among 95 human immunodeficiency virus-infected Thai children who were treated with dual nucleoside reverse-transcriptase inhibitors. Almost all children had resistance to at least 1 NRTI, and approximately h...

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Veröffentlicht in:	Clinical infectious diseases 2005-01, Vol.40 (2), p.309-312
Hauptverfasser:	Lolekha, Rangsima, Sirivichayakul, Sunee, Siangphoe, Umaporn, Pancharoen, Chitsanu, Kaewchana, Suchada, Apateerapong, Wichitra, Mahanontharit, Apicha, Chotpitayasunondh, Tawee, Ruxrungtham, Kiat, Phanuphak, Praphan, Ananworanich, Jintanat
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretrovirals Antiviral agents Biological and medical sciences Child Child, Preschool Children Cross resistance Cross-Sectional Studies Drug resistance Drug Resistance, Multiple, Viral - drug effects Female Genetic mutation HIV HIV 1 HIV Infections - drug therapy HIV Infections - virology HIV-1 - classification HIV-1 - drug effects HIV-1 - genetics HIV-1 - physiology HIV/AIDS Human immunodeficiency virus Human viral diseases Humans Infections Infectious diseases Male Medical sciences Mutation Nucleosides Pediatrics Pharmacology. Drug treatments Reverse transcriptase inhibitors Reverse Transcriptase Inhibitors - pharmacology Reverse Transcriptase Inhibitors - therapeutic use RNA Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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Zusammenfassung:	The prevalence of nucleoside reverse-transcriptase inhibitor (NRTI) mutations was determined among 95 human immunodeficiency virus-infected Thai children who were treated with dual nucleoside reverse-transcriptase inhibitors. Almost all children had resistance to at least 1 NRTI, and approximately half of the children had resistance to multiple NRTIs. Cross-resistance to stavudine and azidothymidine was universal.
ISSN:	1058-4838 1537-6591
DOI:	10.1086/427026