Abnormalities in aggression and anxiety in transgenic mice overexpressing activin E
To study the function of activin E, a TGF-β superfamily member, in the regulation of affective behavior, we investigated the behavior of transgenic mice overexpressing activin E (TgActβE mice). Male TgActβE mice showed aggressive behavior in resident–intruder tests. In elevated plus-maze tests, the...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2009-07, Vol.385 (3), p.319-323 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Sekiyama, Kazunari Hashimoto, Osamu Ushiro, Yuuki Adachi, Chika Kikusui, Takefumi Tanemura, Kentaro Hasegawa, Yoshihisa |
| description | To study the function of activin E, a TGF-β superfamily member, in the regulation of affective behavior, we investigated the behavior of transgenic mice overexpressing activin E (TgActβE mice). Male TgActβE mice showed aggressive behavior in resident–intruder tests. In elevated plus-maze tests, the percentage of open arm entries was significantly increased in female TgActβE mice compared with that in wild-type mice. Furthermore, female TgActβE mice stayed in the central area for a significantly longer time than wild-type mice in open field tests. These results indicated that TgActβE mice had less anxiety-like behavior. The number of restraint-stress-evoked c-Fos-positive cells in the hypothalamic paraventricular nucleus in TgActβE mice was significantly decreased compared with that in wild-type mice. This suggests that synthesis of corticotrophin-releasing hormone induced by stress was decreased in TgActβE mice. Taking these results together, activin E may act as a regulator of the hypothalamic–pituitary–adrenal axis. |
| doi_str_mv | 10.1016/j.bbrc.2009.05.054 |
| format | Article |
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Male TgActβE mice showed aggressive behavior in resident–intruder tests. In elevated plus-maze tests, the percentage of open arm entries was significantly increased in female TgActβE mice compared with that in wild-type mice. Furthermore, female TgActβE mice stayed in the central area for a significantly longer time than wild-type mice in open field tests. These results indicated that TgActβE mice had less anxiety-like behavior. The number of restraint-stress-evoked c-Fos-positive cells in the hypothalamic paraventricular nucleus in TgActβE mice was significantly decreased compared with that in wild-type mice. This suggests that synthesis of corticotrophin-releasing hormone induced by stress was decreased in TgActβE mice. 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Male TgActβE mice showed aggressive behavior in resident–intruder tests. In elevated plus-maze tests, the percentage of open arm entries was significantly increased in female TgActβE mice compared with that in wild-type mice. Furthermore, female TgActβE mice stayed in the central area for a significantly longer time than wild-type mice in open field tests. These results indicated that TgActβE mice had less anxiety-like behavior. The number of restraint-stress-evoked c-Fos-positive cells in the hypothalamic paraventricular nucleus in TgActβE mice was significantly decreased compared with that in wild-type mice. This suggests that synthesis of corticotrophin-releasing hormone induced by stress was decreased in TgActβE mice. Taking these results together, activin E may act as a regulator of the hypothalamic–pituitary–adrenal axis.</description><subject>Activin E</subject><subject>Aggression</subject><subject>Animals</subject><subject>Anxiety</subject><subject>Anxiety - genetics</subject><subject>Anxiety - psychology</subject><subject>Female</subject><subject>Hypothalamo-Hypophyseal System - physiology</subject><subject>Inhibin-beta Subunits - genetics</subject><subject>Inhibin-beta Subunits - physiology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Pituitary-Adrenal System - physiology</subject><subject>Proto-Oncogene Proteins c-fos - metabolism</subject><subject>Transgenic mouse</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotlb_gAfZk7etk49NuuBFpH6A4EEFbyHJzpaU7m5NtqX996a24E1hhgnMMy_kIeSSwpgClTfzsbXBjRlAOYYilTgiQwol5IyCOCZDAJA5K-nngJzFOAegVMjylAxoKSRXk2JI3u5s24XGLHzvMWa-zcxsFjBG36VnW6XeeOy3u00fTBtn2HqXNd5h1q0x4Gb5Q7ezzLjerxM2PScntVlEvDjMEfl4mL7fP-Uvr4_P93cvuRMF7XNhLZtY45i0lJfGVkpRJhxF4NJaBU4osEVdM0F5AWAqVJwXRVWjYYrLmo_I9T53GbqvFcZeNz46XCxMi90qaqm4Sn-Gf0EGUqTmCWR70IUuxoC1XgbfmLDVFPTOuZ7rnXO9c66hSCXS0dUhfWUbrH5PDpITcLsHMMlYeww6Oo-tw8oHdL2uOv9X_jcNyZMz</recordid><startdate>20090731</startdate><enddate>20090731</enddate><creator>Sekiyama, Kazunari</creator><creator>Hashimoto, Osamu</creator><creator>Ushiro, Yuuki</creator><creator>Adachi, Chika</creator><creator>Kikusui, Takefumi</creator><creator>Tanemura, Kentaro</creator><creator>Hasegawa, Yoshihisa</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20090731</creationdate><title>Abnormalities in aggression and anxiety in transgenic mice overexpressing activin E</title><author>Sekiyama, Kazunari ; 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Male TgActβE mice showed aggressive behavior in resident–intruder tests. In elevated plus-maze tests, the percentage of open arm entries was significantly increased in female TgActβE mice compared with that in wild-type mice. Furthermore, female TgActβE mice stayed in the central area for a significantly longer time than wild-type mice in open field tests. These results indicated that TgActβE mice had less anxiety-like behavior. The number of restraint-stress-evoked c-Fos-positive cells in the hypothalamic paraventricular nucleus in TgActβE mice was significantly decreased compared with that in wild-type mice. This suggests that synthesis of corticotrophin-releasing hormone induced by stress was decreased in TgActβE mice. Taking these results together, activin E may act as a regulator of the hypothalamic–pituitary–adrenal axis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>19463785</pmid><doi>10.1016/j.bbrc.2009.05.054</doi><tpages>5</tpages></addata></record> |
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| subjects | Activin E Aggression Animals Anxiety Anxiety - genetics Anxiety - psychology Female Hypothalamo-Hypophyseal System - physiology Inhibin-beta Subunits - genetics Inhibin-beta Subunits - physiology Male Mice Mice, Transgenic Pituitary-Adrenal System - physiology Proto-Oncogene Proteins c-fos - metabolism Transgenic mouse |
| title | Abnormalities in aggression and anxiety in transgenic mice overexpressing activin E |
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