Ghrelin suppresses secretion of FSH in males
Summary Background Ghrelin decreases the secretion of LH probably by suppressing the release of hypothalamic GnRH. So far however, there is no evidence that ghrelin affects also the secretion of FSH in humans, the other gonadotrophin regulated by GnRH. Objective Our objective was to study the effe...
Gespeichert in:
| Veröffentlicht in: | Clinical endocrinology (Oxford) 2009-06, Vol.70 (6), p.920-923 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 923 |
|---|---|
| container_issue | 6 |
| container_start_page | 920 |
| container_title | Clinical endocrinology (Oxford) |
| container_volume | 70 |
| creator | Kluge, Michael Uhr, Manfred Bleninger, Philipp Yassouridis, Alexander Steiger, Axel |
| description | Summary
Background Ghrelin decreases the secretion of LH probably by suppressing the release of hypothalamic GnRH. So far however, there is no evidence that ghrelin affects also the secretion of FSH in humans, the other gonadotrophin regulated by GnRH.
Objective Our objective was to study the effect of ghrelin on secretion of FSH in humans.
Design/study subjects Nocturnal (20:00–07:00 h) secretion profiles of FSH were measured in 10 healthy males (25·3 ± 3·2 years) twice, receiving 50 µg ghrelin or placebo at 22:00, 23:00, 24:00, and 01:00 h, in this single‐blind, randomized, cross‐over study.
Results Mean FSH plasma levels were significantly (P |
| doi_str_mv | 10.1111/j.1365-2265.2008.03440.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67369909</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67369909</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4350-38fea24cef30c133526c7ff38c21dab83b335540e62110982a04fdf8c008f9d73</originalsourceid><addsrcrecordid>eNqNkE1P4zAQhq3VoqV8_IVVLuyJhLEdO85hD0sEBQnBARBHy3XH2pS06XpaUf49Dq26V3yx5XneGfthLONQ8LQuZgWXWuVCaFUIAFOALEsoNt_YaF_4zkYgAXLQujxkR0QzAFAGqh_skNegSuBixM7HfyN27SKj9XIZkQgpI_QRV22_yPqQXT_eZKk8dx3SCTsIriM83e3H7Pn66qm5ye8exrfNn7vcl1JBLk1AJ0qPQYLnUiqhfRWCNF7wqZsYOUl3aT5qwTnURjgowzQYn34S6mklj9mvbd9l7P-tkVZ23pLHrnML7NdkdSV1XUOdQLMFfeyJIga7jO3cxXfLwQ6m7MwOQuwgxA6m7Kcpu0nRn7sZ68kcp_-DOzUJONsBjrzrQnQL39KeE7xMPbVJ3O8t99Z2-P7lB9jm6n44pXy-zbe0ws0-7-Lr8M9K2Zf7sTWVAtmoS9vID8RmkFI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67369909</pqid></control><display><type>article</type><title>Ghrelin suppresses secretion of FSH in males</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Kluge, Michael ; Uhr, Manfred ; Bleninger, Philipp ; Yassouridis, Alexander ; Steiger, Axel</creator><creatorcontrib>Kluge, Michael ; Uhr, Manfred ; Bleninger, Philipp ; Yassouridis, Alexander ; Steiger, Axel</creatorcontrib><description>Summary
Background Ghrelin decreases the secretion of LH probably by suppressing the release of hypothalamic GnRH. So far however, there is no evidence that ghrelin affects also the secretion of FSH in humans, the other gonadotrophin regulated by GnRH.
Objective Our objective was to study the effect of ghrelin on secretion of FSH in humans.
Design/study subjects Nocturnal (20:00–07:00 h) secretion profiles of FSH were measured in 10 healthy males (25·3 ± 3·2 years) twice, receiving 50 µg ghrelin or placebo at 22:00, 23:00, 24:00, and 01:00 h, in this single‐blind, randomized, cross‐over study.
Results Mean FSH plasma levels were significantly (P < 0·05) lower with ghrelin than placebo between 01:00 and 02:20. Consistently, a significant decrease from baseline was only observed in the ghrelin but not in the placebo condition.
Conclusion This study provides first evidence that ghrelin suppresses the secretion of FSH in humans.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/j.1365-2265.2008.03440.x</identifier><identifier>PMID: 19054012</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Biological and medical sciences ; Cross-Sectional Studies ; Down-Regulation ; Endocrinopathies ; Follicle Stimulating Hormone, Human - blood ; Follicle Stimulating Hormone, Human - secretion ; Fundamental and applied biological sciences. Psychology ; Ghrelin - metabolism ; Humans ; Male ; Medical sciences ; Single-Blind Method ; Vertebrates: endocrinology ; Young Adult</subject><ispartof>Clinical endocrinology (Oxford), 2009-06, Vol.70 (6), p.920-923</ispartof><rights>2009 The Authors. Journal compilation © 2009 Blackwell Publishing Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4350-38fea24cef30c133526c7ff38c21dab83b335540e62110982a04fdf8c008f9d73</citedby><cites>FETCH-LOGICAL-c4350-38fea24cef30c133526c7ff38c21dab83b335540e62110982a04fdf8c008f9d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2265.2008.03440.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2265.2008.03440.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21426568$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19054012$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kluge, Michael</creatorcontrib><creatorcontrib>Uhr, Manfred</creatorcontrib><creatorcontrib>Bleninger, Philipp</creatorcontrib><creatorcontrib>Yassouridis, Alexander</creatorcontrib><creatorcontrib>Steiger, Axel</creatorcontrib><title>Ghrelin suppresses secretion of FSH in males</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Summary
Background Ghrelin decreases the secretion of LH probably by suppressing the release of hypothalamic GnRH. So far however, there is no evidence that ghrelin affects also the secretion of FSH in humans, the other gonadotrophin regulated by GnRH.
Objective Our objective was to study the effect of ghrelin on secretion of FSH in humans.
Design/study subjects Nocturnal (20:00–07:00 h) secretion profiles of FSH were measured in 10 healthy males (25·3 ± 3·2 years) twice, receiving 50 µg ghrelin or placebo at 22:00, 23:00, 24:00, and 01:00 h, in this single‐blind, randomized, cross‐over study.
Results Mean FSH plasma levels were significantly (P < 0·05) lower with ghrelin than placebo between 01:00 and 02:20. Consistently, a significant decrease from baseline was only observed in the ghrelin but not in the placebo condition.
Conclusion This study provides first evidence that ghrelin suppresses the secretion of FSH in humans.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cross-Sectional Studies</subject><subject>Down-Regulation</subject><subject>Endocrinopathies</subject><subject>Follicle Stimulating Hormone, Human - blood</subject><subject>Follicle Stimulating Hormone, Human - secretion</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ghrelin - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Single-Blind Method</subject><subject>Vertebrates: endocrinology</subject><subject>Young Adult</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1P4zAQhq3VoqV8_IVVLuyJhLEdO85hD0sEBQnBARBHy3XH2pS06XpaUf49Dq26V3yx5XneGfthLONQ8LQuZgWXWuVCaFUIAFOALEsoNt_YaF_4zkYgAXLQujxkR0QzAFAGqh_skNegSuBixM7HfyN27SKj9XIZkQgpI_QRV22_yPqQXT_eZKk8dx3SCTsIriM83e3H7Pn66qm5ye8exrfNn7vcl1JBLk1AJ0qPQYLnUiqhfRWCNF7wqZsYOUl3aT5qwTnURjgowzQYn34S6mklj9mvbd9l7P-tkVZ23pLHrnML7NdkdSV1XUOdQLMFfeyJIga7jO3cxXfLwQ6m7MwOQuwgxA6m7Kcpu0nRn7sZ68kcp_-DOzUJONsBjrzrQnQL39KeE7xMPbVJ3O8t99Z2-P7lB9jm6n44pXy-zbe0ws0-7-Lr8M9K2Zf7sTWVAtmoS9vID8RmkFI</recordid><startdate>200906</startdate><enddate>200906</enddate><creator>Kluge, Michael</creator><creator>Uhr, Manfred</creator><creator>Bleninger, Philipp</creator><creator>Yassouridis, Alexander</creator><creator>Steiger, Axel</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200906</creationdate><title>Ghrelin suppresses secretion of FSH in males</title><author>Kluge, Michael ; Uhr, Manfred ; Bleninger, Philipp ; Yassouridis, Alexander ; Steiger, Axel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4350-38fea24cef30c133526c7ff38c21dab83b335540e62110982a04fdf8c008f9d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cross-Sectional Studies</topic><topic>Down-Regulation</topic><topic>Endocrinopathies</topic><topic>Follicle Stimulating Hormone, Human - blood</topic><topic>Follicle Stimulating Hormone, Human - secretion</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ghrelin - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Single-Blind Method</topic><topic>Vertebrates: endocrinology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kluge, Michael</creatorcontrib><creatorcontrib>Uhr, Manfred</creatorcontrib><creatorcontrib>Bleninger, Philipp</creatorcontrib><creatorcontrib>Yassouridis, Alexander</creatorcontrib><creatorcontrib>Steiger, Axel</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kluge, Michael</au><au>Uhr, Manfred</au><au>Bleninger, Philipp</au><au>Yassouridis, Alexander</au><au>Steiger, Axel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ghrelin suppresses secretion of FSH in males</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2009-06</date><risdate>2009</risdate><volume>70</volume><issue>6</issue><spage>920</spage><epage>923</epage><pages>920-923</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
Background Ghrelin decreases the secretion of LH probably by suppressing the release of hypothalamic GnRH. So far however, there is no evidence that ghrelin affects also the secretion of FSH in humans, the other gonadotrophin regulated by GnRH.
Objective Our objective was to study the effect of ghrelin on secretion of FSH in humans.
Design/study subjects Nocturnal (20:00–07:00 h) secretion profiles of FSH were measured in 10 healthy males (25·3 ± 3·2 years) twice, receiving 50 µg ghrelin or placebo at 22:00, 23:00, 24:00, and 01:00 h, in this single‐blind, randomized, cross‐over study.
Results Mean FSH plasma levels were significantly (P < 0·05) lower with ghrelin than placebo between 01:00 and 02:20. Consistently, a significant decrease from baseline was only observed in the ghrelin but not in the placebo condition.
Conclusion This study provides first evidence that ghrelin suppresses the secretion of FSH in humans.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19054012</pmid><doi>10.1111/j.1365-2265.2008.03440.x</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-0664 |
| ispartof | Clinical endocrinology (Oxford), 2009-06, Vol.70 (6), p.920-923 |
| issn | 0300-0664 1365-2265 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67369909 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adult Biological and medical sciences Cross-Sectional Studies Down-Regulation Endocrinopathies Follicle Stimulating Hormone, Human - blood Follicle Stimulating Hormone, Human - secretion Fundamental and applied biological sciences. Psychology Ghrelin - metabolism Humans Male Medical sciences Single-Blind Method Vertebrates: endocrinology Young Adult |
| title | Ghrelin suppresses secretion of FSH in males |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T17%3A12%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ghrelin%20suppresses%20secretion%20of%20FSH%20in%20males&rft.jtitle=Clinical%20endocrinology%20(Oxford)&rft.au=Kluge,%20Michael&rft.date=2009-06&rft.volume=70&rft.issue=6&rft.spage=920&rft.epage=923&rft.pages=920-923&rft.issn=0300-0664&rft.eissn=1365-2265&rft.coden=CLECAP&rft_id=info:doi/10.1111/j.1365-2265.2008.03440.x&rft_dat=%3Cproquest_cross%3E67369909%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67369909&rft_id=info:pmid/19054012&rfr_iscdi=true |