Ghrelin suppresses secretion of FSH in males

Summary Background Ghrelin decreases the secretion of LH probably by suppressing the release of hypothalamic GnRH. So far however, there is no evidence that ghrelin affects also the secretion of FSH in humans, the other gonadotrophin regulated by GnRH. Objective Our objective was to study the effe...

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Veröffentlicht in:	Clinical endocrinology (Oxford) 2009-06, Vol.70 (6), p.920-923
Hauptverfasser:	Kluge, Michael, Uhr, Manfred, Bleninger, Philipp, Yassouridis, Alexander, Steiger, Axel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Cross-Sectional Studies Down-Regulation Endocrinopathies Follicle Stimulating Hormone, Human - blood Follicle Stimulating Hormone, Human - secretion Fundamental and applied biological sciences. Psychology Ghrelin - metabolism Humans Male Medical sciences Single-Blind Method Vertebrates: endocrinology Young Adult
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Zusammenfassung:	Summary Background Ghrelin decreases the secretion of LH probably by suppressing the release of hypothalamic GnRH. So far however, there is no evidence that ghrelin affects also the secretion of FSH in humans, the other gonadotrophin regulated by GnRH. Objective Our objective was to study the effect of ghrelin on secretion of FSH in humans. Design/study subjects Nocturnal (20:00–07:00 h) secretion profiles of FSH were measured in 10 healthy males (25·3 ± 3·2 years) twice, receiving 50 µg ghrelin or placebo at 22:00, 23:00, 24:00, and 01:00 h, in this single‐blind, randomized, cross‐over study. Results Mean FSH plasma levels were significantly (P
ISSN:	0300-0664 1365-2265
DOI:	10.1111/j.1365-2265.2008.03440.x