Crystal Structure of the Ligand Binding Suppressor Domain of Type 1 Inositol 1,4,5-Trisphosphate Receptor

Binding of inositol 1,4,5-trisphosphate (IP 3) to the amino-terminal region of IP 3 receptor promotes Ca 2+ release from the endoplasmic reticulum. Within the amino terminus, the first 220 residues directly preceding the IP 3 binding core domain play a key role in IP 3 binding suppression and regula...

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Veröffentlicht in:	Molecular cell 2005-01, Vol.17 (2), p.193-203
Hauptverfasser:	Bosanac, Ivan, Yamazaki, Haruka, Matsu-ura, Toru, Michikawa, Takayuki, Mikoshiba, Katsuhiko, Ikura, Mitsuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Calcium Channels - chemistry Calcium Channels - metabolism Crystallography, X-Ray Humans Inositol 1,4,5-Trisphosphate Receptors Ligands Mice Models, Molecular Molecular Sequence Data Protein Binding Protein Folding Protein Structure, Secondary Protein Structure, Tertiary Receptors, Cytoplasmic and Nuclear - chemistry Receptors, Cytoplasmic and Nuclear - metabolism Ryanodine Receptor Calcium Release Channel - chemistry Sequence Alignment
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