Limited Ability of Antigen-Specific Th1 Responses to Inhibit Th2 Cell Development In Vivo
Th1 and Th2 cells mutually antagonize each other's differentiation. Consequently, allergen-specific Th1 cells are believed to be able to suppress the development of Th2 cells and to prevent the development of atopic disorders. To determine whether a pre-existing Ag-specific Th1 response can aff...
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| Veröffentlicht in: | The Journal of immunology (1950) 2005-02, Vol.174 (3), p.1325-1331 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 174 |
| creator | Yasumi, Takahiro Katamura, Kenji Okafuji, Ikuo Yoshioka, Takakazu Meguro, Taka-aki Nishikomori, Ryuta Kusunoki, Takashi Heike, Toshio Nakahata, Tatsutoshi |
| description | Th1 and Th2 cells mutually antagonize each other's differentiation. Consequently, allergen-specific Th1 cells are believed to be able to suppress the development of Th2 cells and to prevent the development of atopic disorders. To determine whether a pre-existing Ag-specific Th1 response can affect the development of Th2 cells in vivo, we used an immunization model of Ag-pulsed murine dendritic cell (DC) transfer to induce distinct Th responses. When transferred into naive mice, Ag-pulsed CD8alpha(+) DCs induced a Th1 response and the production of IgG2a, whereas CD8alpha(-) DCs primed a Th2 response and the production of IgE. In the presence of a pre-existing Ag-specific Th2 environment due to Ag-pulsed CD8alpha(-) DC transfer, CD8alpha(+) DCs failed to prime Th1 cells. In contrast, CD8alpha(-) DCs could prime a Th2 response in the presence of a pre-existing Ag-specific Th1 environment. Moreover, exogenous IL-4 abolished the Th1-inducing potential of CD8alpha(+) DCs in vitro, but the addition of IFN-gamma did not effectively inhibit the potential of CD8alpha(-) DCs to prime IL-4-producing cells. Thus, Th1 and Th2 cells differ in their potential to inhibit the development of the other. This suggests that the early induction of allergen-specific Th1 cells before allergy sensitization will not prevent the development of atopic disorders. |
| doi_str_mv | 10.4049/jimmunol.174.3.1325 |
| format | Article |
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Consequently, allergen-specific Th1 cells are believed to be able to suppress the development of Th2 cells and to prevent the development of atopic disorders. To determine whether a pre-existing Ag-specific Th1 response can affect the development of Th2 cells in vivo, we used an immunization model of Ag-pulsed murine dendritic cell (DC) transfer to induce distinct Th responses. When transferred into naive mice, Ag-pulsed CD8alpha(+) DCs induced a Th1 response and the production of IgG2a, whereas CD8alpha(-) DCs primed a Th2 response and the production of IgE. In the presence of a pre-existing Ag-specific Th2 environment due to Ag-pulsed CD8alpha(-) DC transfer, CD8alpha(+) DCs failed to prime Th1 cells. In contrast, CD8alpha(-) DCs could prime a Th2 response in the presence of a pre-existing Ag-specific Th1 environment. Moreover, exogenous IL-4 abolished the Th1-inducing potential of CD8alpha(+) DCs in vitro, but the addition of IFN-gamma did not effectively inhibit the potential of CD8alpha(-) DCs to prime IL-4-producing cells. Thus, Th1 and Th2 cells differ in their potential to inhibit the development of the other. This suggests that the early induction of allergen-specific Th1 cells before allergy sensitization will not prevent the development of atopic disorders.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.174.3.1325</identifier><identifier>PMID: 15661889</identifier><language>eng</language><publisher>United States: Am Assoc Immnol</publisher><subject>Adoptive Transfer ; Animals ; CD8 Antigens - biosynthesis ; Cell Communication - immunology ; Cell Differentiation - immunology ; Dendritic Cells - immunology ; Dendritic Cells - metabolism ; Dendritic Cells - transplantation ; Epitopes, T-Lymphocyte - immunology ; Growth Inhibitors - pharmacology ; Growth Inhibitors - physiology ; Immunoglobulin G - biosynthesis ; Immunosuppression ; Interferon-gamma - biosynthesis ; Interferon-gamma - physiology ; Interleukin-4 - biosynthesis ; Interleukin-4 - pharmacology ; Mice ; Mice, Inbred BALB C ; Mice, Transgenic ; Resting Phase, Cell Cycle - immunology ; Spleen - cytology ; Spleen - immunology ; Spleen - metabolism ; T-Lymphocytes, Helper-Inducer - cytology ; T-Lymphocytes, Helper-Inducer - immunology ; T-Lymphocytes, Helper-Inducer - metabolism ; Th1 Cells - cytology ; Th1 Cells - immunology ; Th1 Cells - metabolism ; Th2 Cells - cytology ; Th2 Cells - immunology ; Th2 Cells - metabolism</subject><ispartof>The Journal of immunology (1950), 2005-02, Vol.174 (3), p.1325-1331</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-6bee15451ef5bc5b45013e17f26e112cb8a5cda8f637dca388e6b9d2122a5c523</citedby><cites>FETCH-LOGICAL-c477t-6bee15451ef5bc5b45013e17f26e112cb8a5cda8f637dca388e6b9d2122a5c523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15661889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yasumi, Takahiro</creatorcontrib><creatorcontrib>Katamura, Kenji</creatorcontrib><creatorcontrib>Okafuji, Ikuo</creatorcontrib><creatorcontrib>Yoshioka, Takakazu</creatorcontrib><creatorcontrib>Meguro, Taka-aki</creatorcontrib><creatorcontrib>Nishikomori, Ryuta</creatorcontrib><creatorcontrib>Kusunoki, Takashi</creatorcontrib><creatorcontrib>Heike, Toshio</creatorcontrib><creatorcontrib>Nakahata, Tatsutoshi</creatorcontrib><title>Limited Ability of Antigen-Specific Th1 Responses to Inhibit Th2 Cell Development In Vivo</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>Th1 and Th2 cells mutually antagonize each other's differentiation. Consequently, allergen-specific Th1 cells are believed to be able to suppress the development of Th2 cells and to prevent the development of atopic disorders. To determine whether a pre-existing Ag-specific Th1 response can affect the development of Th2 cells in vivo, we used an immunization model of Ag-pulsed murine dendritic cell (DC) transfer to induce distinct Th responses. When transferred into naive mice, Ag-pulsed CD8alpha(+) DCs induced a Th1 response and the production of IgG2a, whereas CD8alpha(-) DCs primed a Th2 response and the production of IgE. In the presence of a pre-existing Ag-specific Th2 environment due to Ag-pulsed CD8alpha(-) DC transfer, CD8alpha(+) DCs failed to prime Th1 cells. In contrast, CD8alpha(-) DCs could prime a Th2 response in the presence of a pre-existing Ag-specific Th1 environment. Moreover, exogenous IL-4 abolished the Th1-inducing potential of CD8alpha(+) DCs in vitro, but the addition of IFN-gamma did not effectively inhibit the potential of CD8alpha(-) DCs to prime IL-4-producing cells. Thus, Th1 and Th2 cells differ in their potential to inhibit the development of the other. This suggests that the early induction of allergen-specific Th1 cells before allergy sensitization will not prevent the development of atopic disorders.</description><subject>Adoptive Transfer</subject><subject>Animals</subject><subject>CD8 Antigens - biosynthesis</subject><subject>Cell Communication - immunology</subject><subject>Cell Differentiation - immunology</subject><subject>Dendritic Cells - immunology</subject><subject>Dendritic Cells - metabolism</subject><subject>Dendritic Cells - transplantation</subject><subject>Epitopes, T-Lymphocyte - immunology</subject><subject>Growth Inhibitors - pharmacology</subject><subject>Growth Inhibitors - physiology</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Immunosuppression</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Interferon-gamma - physiology</subject><subject>Interleukin-4 - biosynthesis</subject><subject>Interleukin-4 - pharmacology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Transgenic</subject><subject>Resting Phase, Cell Cycle - immunology</subject><subject>Spleen - cytology</subject><subject>Spleen - immunology</subject><subject>Spleen - metabolism</subject><subject>T-Lymphocytes, Helper-Inducer - cytology</subject><subject>T-Lymphocytes, Helper-Inducer - immunology</subject><subject>T-Lymphocytes, Helper-Inducer - metabolism</subject><subject>Th1 Cells - cytology</subject><subject>Th1 Cells - immunology</subject><subject>Th1 Cells - metabolism</subject><subject>Th2 Cells - cytology</subject><subject>Th2 Cells - immunology</subject><subject>Th2 Cells - metabolism</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtr20AUhYfSULtpfkGhzKpdyZk7T3lpnLYxGAJ5FLIapNFVPEbSqBrZJv--E-zQ7LK6i_Odw-Uj5CuwmWRyfrn1bbvrQjMDI2diBoKrD2QKSrFMa6Y_kiljnGdgtJmQzzFuGWOacfmJTEBpDXk-n5LHtW_9iBVdlL7x4zMNNV10o3_CLrvr0fnaO3q_AXqLsQ9dxEjHQFfdxpd-TAGnS2waeoV7bELfYjemkP7x-_CFnNVFE_HidM_Jw6-f98vrbH3ze7VcrDMnjRkzXSKCkgqwVqVTpVQMBIKpuUYA7sq8UK4q8loLU7lC5Dnqcl5x4DwFiotz8v242w_h7w7jaFsfXXqq6DDsotVG6DmX-bsgGKMly1UCxRF0Q4hxwNr2g2-L4dkCsy_q7av61JFW2Bf1qfXtNL8rW6z-d06uE_DjCGz80-bgB7SxLZom4WAPh8ObqX_jno6e</recordid><startdate>20050201</startdate><enddate>20050201</enddate><creator>Yasumi, Takahiro</creator><creator>Katamura, Kenji</creator><creator>Okafuji, Ikuo</creator><creator>Yoshioka, Takakazu</creator><creator>Meguro, Taka-aki</creator><creator>Nishikomori, Ryuta</creator><creator>Kusunoki, Takashi</creator><creator>Heike, Toshio</creator><creator>Nakahata, Tatsutoshi</creator><general>Am Assoc Immnol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20050201</creationdate><title>Limited Ability of Antigen-Specific Th1 Responses to Inhibit Th2 Cell Development In Vivo</title><author>Yasumi, Takahiro ; Katamura, Kenji ; Okafuji, Ikuo ; Yoshioka, Takakazu ; Meguro, Taka-aki ; Nishikomori, Ryuta ; Kusunoki, Takashi ; Heike, Toshio ; Nakahata, Tatsutoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-6bee15451ef5bc5b45013e17f26e112cb8a5cda8f637dca388e6b9d2122a5c523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adoptive Transfer</topic><topic>Animals</topic><topic>CD8 Antigens - biosynthesis</topic><topic>Cell Communication - immunology</topic><topic>Cell Differentiation - immunology</topic><topic>Dendritic Cells - immunology</topic><topic>Dendritic Cells - metabolism</topic><topic>Dendritic Cells - transplantation</topic><topic>Epitopes, T-Lymphocyte - immunology</topic><topic>Growth Inhibitors - pharmacology</topic><topic>Growth Inhibitors - physiology</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Immunosuppression</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Interferon-gamma - physiology</topic><topic>Interleukin-4 - biosynthesis</topic><topic>Interleukin-4 - pharmacology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Transgenic</topic><topic>Resting Phase, Cell Cycle - immunology</topic><topic>Spleen - cytology</topic><topic>Spleen - immunology</topic><topic>Spleen - metabolism</topic><topic>T-Lymphocytes, Helper-Inducer - cytology</topic><topic>T-Lymphocytes, Helper-Inducer - immunology</topic><topic>T-Lymphocytes, Helper-Inducer - metabolism</topic><topic>Th1 Cells - cytology</topic><topic>Th1 Cells - immunology</topic><topic>Th1 Cells - metabolism</topic><topic>Th2 Cells - cytology</topic><topic>Th2 Cells - immunology</topic><topic>Th2 Cells - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yasumi, Takahiro</creatorcontrib><creatorcontrib>Katamura, Kenji</creatorcontrib><creatorcontrib>Okafuji, Ikuo</creatorcontrib><creatorcontrib>Yoshioka, Takakazu</creatorcontrib><creatorcontrib>Meguro, Taka-aki</creatorcontrib><creatorcontrib>Nishikomori, Ryuta</creatorcontrib><creatorcontrib>Kusunoki, Takashi</creatorcontrib><creatorcontrib>Heike, Toshio</creatorcontrib><creatorcontrib>Nakahata, Tatsutoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yasumi, Takahiro</au><au>Katamura, Kenji</au><au>Okafuji, Ikuo</au><au>Yoshioka, Takakazu</au><au>Meguro, Taka-aki</au><au>Nishikomori, Ryuta</au><au>Kusunoki, Takashi</au><au>Heike, Toshio</au><au>Nakahata, Tatsutoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Limited Ability of Antigen-Specific Th1 Responses to Inhibit Th2 Cell Development In Vivo</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>2005-02-01</date><risdate>2005</risdate><volume>174</volume><issue>3</issue><spage>1325</spage><epage>1331</epage><pages>1325-1331</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>Th1 and Th2 cells mutually antagonize each other's differentiation. Consequently, allergen-specific Th1 cells are believed to be able to suppress the development of Th2 cells and to prevent the development of atopic disorders. To determine whether a pre-existing Ag-specific Th1 response can affect the development of Th2 cells in vivo, we used an immunization model of Ag-pulsed murine dendritic cell (DC) transfer to induce distinct Th responses. When transferred into naive mice, Ag-pulsed CD8alpha(+) DCs induced a Th1 response and the production of IgG2a, whereas CD8alpha(-) DCs primed a Th2 response and the production of IgE. In the presence of a pre-existing Ag-specific Th2 environment due to Ag-pulsed CD8alpha(-) DC transfer, CD8alpha(+) DCs failed to prime Th1 cells. In contrast, CD8alpha(-) DCs could prime a Th2 response in the presence of a pre-existing Ag-specific Th1 environment. Moreover, exogenous IL-4 abolished the Th1-inducing potential of CD8alpha(+) DCs in vitro, but the addition of IFN-gamma did not effectively inhibit the potential of CD8alpha(-) DCs to prime IL-4-producing cells. Thus, Th1 and Th2 cells differ in their potential to inhibit the development of the other. This suggests that the early induction of allergen-specific Th1 cells before allergy sensitization will not prevent the development of atopic disorders.</abstract><cop>United States</cop><pub>Am Assoc Immnol</pub><pmid>15661889</pmid><doi>10.4049/jimmunol.174.3.1325</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adoptive Transfer Animals CD8 Antigens - biosynthesis Cell Communication - immunology Cell Differentiation - immunology Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - transplantation Epitopes, T-Lymphocyte - immunology Growth Inhibitors - pharmacology Growth Inhibitors - physiology Immunoglobulin G - biosynthesis Immunosuppression Interferon-gamma - biosynthesis Interferon-gamma - physiology Interleukin-4 - biosynthesis Interleukin-4 - pharmacology Mice Mice, Inbred BALB C Mice, Transgenic Resting Phase, Cell Cycle - immunology Spleen - cytology Spleen - immunology Spleen - metabolism T-Lymphocytes, Helper-Inducer - cytology T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism Th1 Cells - cytology Th1 Cells - immunology Th1 Cells - metabolism Th2 Cells - cytology Th2 Cells - immunology Th2 Cells - metabolism |
| title | Limited Ability of Antigen-Specific Th1 Responses to Inhibit Th2 Cell Development In Vivo |
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