Therapeutic Effect of Vitamin D3 in a Rat Diffuse Axonal Injury Model

Therapeutic Effect of Vitamin D3 in a Rat Diffuse Axonal Injury Model

We investigated the therapeutic effect of vitamin D3 in a rat diffuse axonal injury model. A total of 60 male Sprague-Dawley rats weighing 175 − 200 g were anaesthetized and subjected to head trauma using Marmarou's impact-acceleration model. The rats were then separated into two groups; one gr...

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Veröffentlicht in:Journal of international medical research 2005, Vol.33 (1), p.90-95
Hauptverfasser: Malcok, UA, Sengul, G, Kadioglu, HH, Aydin, IH
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Sprache:eng
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Animals
Axons
Cholecalciferol - therapeutic use
Male
Models, Animal
Rats
Rats, Sprague-Dawley
Wounds and Injuries - drug therapy
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Sengul, G
Kadioglu, HH
Aydin, IH
description We investigated the therapeutic effect of vitamin D3 in a rat diffuse axonal injury model. A total of 60 male Sprague-Dawley rats weighing 175 − 200 g were anaesthetized and subjected to head trauma using Marmarou's impact-acceleration model. The rats were then separated into two groups; one group was treated with vitamin D3 and the other with saline for up to 4 days after the head trauma. Rats from both groups were killed 1, 3 or 8 days post-injury. The brains were examined histopathologically and scored according to the level of neuronal, vascular and axonal damage. There were no significant differences between the groups after 1 or 3 days, but evaluation after 8 days revealed a significant improvement in the group treated with vitamin D3. Our data indicate that vitamin D3 has a beneficial effect in diffuse axonal injury and may be useful in the management of this condition.
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subjects Animals
Axons
Cholecalciferol - therapeutic use
Male
Models, Animal
Rats
Rats, Sprague-Dawley
Wounds and Injuries - drug therapy
title Therapeutic Effect of Vitamin D3 in a Rat Diffuse Axonal Injury Model
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