Prolonged platelet preservation by transient metabolic suppression

BACKGROUND: In this study whether metabolic suppression can be used to preserve platelet (PLT) function during prolonged storage was investigated. STUDY DESIGN AND METHODS: Washed human PLTs were incubated without glucose and with antimycin A to block energy generation. Metabolic suppressed PLTs (...

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Veröffentlicht in:	Transfusion (Philadelphia, Pa.) Pa.), 2005-02, Vol.45 (2), p.214-222
Hauptverfasser:	Badlou, B.A., IJseldijk, M.J.W., Smid, W.M., Akkerman, J.W.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood coagulation. Blood cells Blood Platelets - metabolism Blood Preservation - methods Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Cold Temperature Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Energy Metabolism Fibrinogen - metabolism Fundamental and applied biological sciences. Psychology Glucose - metabolism Humans Intensive care medicine Medical sciences Molecular and cellular biology P-Selectin Platelet Platelet Adhesiveness Platelet Aggregation Platelet Glycoprotein GPIb-IX Complex - metabolism Platelet Transfusion Transfusions. Complications. Transfusion reactions. Cell and gene therapy von Willebrand Factor - metabolism
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