Factor II: C activity and uterine artery Doppler evaluation to improve the early prediction of pre-eclampsia on women with gestational hypertension
OBJECTIVETo evaluate whether the determination of maternal plasma Factor II:C (FII:C) and mean uterine artery resistance index may be useful to early predict pre-eclampsia in patients with gestational hypertension. DESIGNProspective study. SETTINGConsecutive enrollment in a public tertiary clinical...
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| Veröffentlicht in: | Journal of hypertension 2005-01, Vol.23 (1), p.141-146 |
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| container_title | Journal of hypertension |
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| creator | Florio, Pasquale D'Aniello, Gemma Sabatini, Laura Severi, Filiberto M Fineschi, Daniela Bocchi, Caterina Reis, Fernando M Petraglia, Felice |
| description | OBJECTIVETo evaluate whether the determination of maternal plasma Factor II:C (FII:C) and mean uterine artery resistance index may be useful to early predict pre-eclampsia in patients with gestational hypertension.
DESIGNProspective study.
SETTINGConsecutive enrollment in a public tertiary clinical care centre.
PATIENTSA total of 65 women with gestational hypertension at 24–26 weeks.
INTERVENTIONMeasurements of maternal plasma FII:C activity levels, ultrasonographic biometrical parameters and Doppler velocimetry of maternal uterine arteries.
MAIN OUTCOME MEASURE(S)The probability of developing pre-eclampsia was the main outcome of the study and it was computed by combining the FII:C and the mean uterine artery resistance index cut-off points, chosen by receiver operating characteristic (ROC) curve analysis.
RESULTSF-II:C activity levels and mean uterine artery resistance index were significantly (both P < 0.01) higher in women who developed pre-eclampsia. A weak, but significant correlation (r = 0.3, P < 0.05) was found between these two parameters. FII:C activity levels at the cut-off value of 136.5% achieved a sensitivity of 61.1% and a specificity of 71.3%, while mean uterine artery resistance index (RI) at the cut-off value of 0.57 showed a sensitivity of 85.7% and a specificity of 90.2% in predicting the onset of pre-eclampsia. When both FII:C and mean uterine RI were over the cut-off points the positive predictive value was of 89%, with a 100% negative predictive value when both were below the cut-off points.
CONCLUSIONF-II:C activity levels and mean uterine artery resistance index determination at mid trimester may improve the prediction of superimposed pre-eclampsia on women with early onset gestational hypertension. |
| doi_str_mv | 10.1097/00004872-200501000-00024 |
| format | Article |
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DESIGNProspective study.
SETTINGConsecutive enrollment in a public tertiary clinical care centre.
PATIENTSA total of 65 women with gestational hypertension at 24–26 weeks.
INTERVENTIONMeasurements of maternal plasma FII:C activity levels, ultrasonographic biometrical parameters and Doppler velocimetry of maternal uterine arteries.
MAIN OUTCOME MEASURE(S)The probability of developing pre-eclampsia was the main outcome of the study and it was computed by combining the FII:C and the mean uterine artery resistance index cut-off points, chosen by receiver operating characteristic (ROC) curve analysis.
RESULTSF-II:C activity levels and mean uterine artery resistance index were significantly (both P < 0.01) higher in women who developed pre-eclampsia. A weak, but significant correlation (r = 0.3, P < 0.05) was found between these two parameters. FII:C activity levels at the cut-off value of 136.5% achieved a sensitivity of 61.1% and a specificity of 71.3%, while mean uterine artery resistance index (RI) at the cut-off value of 0.57 showed a sensitivity of 85.7% and a specificity of 90.2% in predicting the onset of pre-eclampsia. When both FII:C and mean uterine RI were over the cut-off points the positive predictive value was of 89%, with a 100% negative predictive value when both were below the cut-off points.
CONCLUSIONF-II:C activity levels and mean uterine artery resistance index determination at mid trimester may improve the prediction of superimposed pre-eclampsia on women with early onset gestational hypertension.</description><identifier>ISSN: 0263-6352</identifier><identifier>EISSN: 1473-5598</identifier><identifier>DOI: 10.1097/00004872-200501000-00024</identifier><identifier>PMID: 15643136</identifier><language>eng</language><publisher>England: Lippincott Williams & Wilkins, Inc</publisher><subject>Adult ; Biomarkers ; Early Diagnosis ; Female ; Humans ; Hypertension, Pregnancy-Induced - blood ; Hypertension, Pregnancy-Induced - diagnostic imaging ; Hypertension, Pregnancy-Induced - epidemiology ; Pre-Eclampsia - blood ; Pre-Eclampsia - diagnostic imaging ; Pre-Eclampsia - epidemiology ; Predictive Value of Tests ; Pregnancy ; Prospective Studies ; Prothrombin - metabolism ; Risk Factors ; ROC Curve ; Ultrasonography, Doppler ; Uterus - blood supply ; von Willebrand Factor</subject><ispartof>Journal of hypertension, 2005-01, Vol.23 (1), p.141-146</ispartof><rights>2005 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3034-281f678cc4be3c076fac20b18f7cf49b4e5a0c7246ad71fd98527aa2a08505093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15643136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Florio, Pasquale</creatorcontrib><creatorcontrib>D'Aniello, Gemma</creatorcontrib><creatorcontrib>Sabatini, Laura</creatorcontrib><creatorcontrib>Severi, Filiberto M</creatorcontrib><creatorcontrib>Fineschi, Daniela</creatorcontrib><creatorcontrib>Bocchi, Caterina</creatorcontrib><creatorcontrib>Reis, Fernando M</creatorcontrib><creatorcontrib>Petraglia, Felice</creatorcontrib><title>Factor II: C activity and uterine artery Doppler evaluation to improve the early prediction of pre-eclampsia on women with gestational hypertension</title><title>Journal of hypertension</title><addtitle>J Hypertens</addtitle><description>OBJECTIVETo evaluate whether the determination of maternal plasma Factor II:C (FII:C) and mean uterine artery resistance index may be useful to early predict pre-eclampsia in patients with gestational hypertension.
DESIGNProspective study.
SETTINGConsecutive enrollment in a public tertiary clinical care centre.
PATIENTSA total of 65 women with gestational hypertension at 24–26 weeks.
INTERVENTIONMeasurements of maternal plasma FII:C activity levels, ultrasonographic biometrical parameters and Doppler velocimetry of maternal uterine arteries.
MAIN OUTCOME MEASURE(S)The probability of developing pre-eclampsia was the main outcome of the study and it was computed by combining the FII:C and the mean uterine artery resistance index cut-off points, chosen by receiver operating characteristic (ROC) curve analysis.
RESULTSF-II:C activity levels and mean uterine artery resistance index were significantly (both P < 0.01) higher in women who developed pre-eclampsia. A weak, but significant correlation (r = 0.3, P < 0.05) was found between these two parameters. FII:C activity levels at the cut-off value of 136.5% achieved a sensitivity of 61.1% and a specificity of 71.3%, while mean uterine artery resistance index (RI) at the cut-off value of 0.57 showed a sensitivity of 85.7% and a specificity of 90.2% in predicting the onset of pre-eclampsia. When both FII:C and mean uterine RI were over the cut-off points the positive predictive value was of 89%, with a 100% negative predictive value when both were below the cut-off points.
CONCLUSIONF-II:C activity levels and mean uterine artery resistance index determination at mid trimester may improve the prediction of superimposed pre-eclampsia on women with early onset gestational hypertension.</description><subject>Adult</subject><subject>Biomarkers</subject><subject>Early Diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension, Pregnancy-Induced - blood</subject><subject>Hypertension, Pregnancy-Induced - diagnostic imaging</subject><subject>Hypertension, Pregnancy-Induced - epidemiology</subject><subject>Pre-Eclampsia - blood</subject><subject>Pre-Eclampsia - diagnostic imaging</subject><subject>Pre-Eclampsia - epidemiology</subject><subject>Predictive Value of Tests</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><subject>Prothrombin - metabolism</subject><subject>Risk Factors</subject><subject>ROC Curve</subject><subject>Ultrasonography, Doppler</subject><subject>Uterus - blood supply</subject><subject>von Willebrand Factor</subject><issn>0263-6352</issn><issn>1473-5598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc2O0zAQxy0EYsvCKyCfuAX8ldjhhgoLlVbiAmdr6kyIwamDnbTKc_DCeNsCJyzZnrH_M2PPjxDK2WvOWv2GlaGMFpVgrGa8eFWZQj0iG660rOq6NY_JholGVo2sxQ15lvP3IjGtlk_JDa8bJblsNuTXHbg5JrrbvaVbWmx_9PNK4dDRZcbkD0ghFWOl7-M0BUwUjxAWmH080DlSP04pHpHOA1KEFFY6Jey8O9_H_sGr0AUYp-yBlrNTHLGsfh7oN8zzOREEOqwTljqHXNzn5EkPIeOL635Lvt59-LL9VN1__rjbvruvnGRSVcLwvtHGObVH6ZhuenCC7bnptetVu1dYA3NaqAY6zfuuNbXQAAKYqUvXWnlLXl3yli_8XMpj7OizwxDggHHJttGyMabWRWguQpdizgl7OyU_QlotZ_YBiP0DxP4FYs9ASujLa41lP2L3L_BKoAjURXCKofQ5_wjLCZMdEMI82P-Blr8BhKGYeA</recordid><startdate>200501</startdate><enddate>200501</enddate><creator>Florio, Pasquale</creator><creator>D'Aniello, Gemma</creator><creator>Sabatini, Laura</creator><creator>Severi, Filiberto M</creator><creator>Fineschi, Daniela</creator><creator>Bocchi, Caterina</creator><creator>Reis, Fernando M</creator><creator>Petraglia, Felice</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200501</creationdate><title>Factor II: C activity and uterine artery Doppler evaluation to improve the early prediction of pre-eclampsia on women with gestational hypertension</title><author>Florio, Pasquale ; D'Aniello, Gemma ; Sabatini, Laura ; Severi, Filiberto M ; Fineschi, Daniela ; Bocchi, Caterina ; Reis, Fernando M ; Petraglia, Felice</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3034-281f678cc4be3c076fac20b18f7cf49b4e5a0c7246ad71fd98527aa2a08505093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Biomarkers</topic><topic>Early Diagnosis</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension, Pregnancy-Induced - blood</topic><topic>Hypertension, Pregnancy-Induced - diagnostic imaging</topic><topic>Hypertension, Pregnancy-Induced - epidemiology</topic><topic>Pre-Eclampsia - blood</topic><topic>Pre-Eclampsia - diagnostic imaging</topic><topic>Pre-Eclampsia - epidemiology</topic><topic>Predictive Value of Tests</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><topic>Prothrombin - metabolism</topic><topic>Risk Factors</topic><topic>ROC Curve</topic><topic>Ultrasonography, Doppler</topic><topic>Uterus - blood supply</topic><topic>von Willebrand Factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Florio, Pasquale</creatorcontrib><creatorcontrib>D'Aniello, Gemma</creatorcontrib><creatorcontrib>Sabatini, Laura</creatorcontrib><creatorcontrib>Severi, Filiberto M</creatorcontrib><creatorcontrib>Fineschi, Daniela</creatorcontrib><creatorcontrib>Bocchi, Caterina</creatorcontrib><creatorcontrib>Reis, Fernando M</creatorcontrib><creatorcontrib>Petraglia, Felice</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Florio, Pasquale</au><au>D'Aniello, Gemma</au><au>Sabatini, Laura</au><au>Severi, Filiberto M</au><au>Fineschi, Daniela</au><au>Bocchi, Caterina</au><au>Reis, Fernando M</au><au>Petraglia, Felice</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factor II: C activity and uterine artery Doppler evaluation to improve the early prediction of pre-eclampsia on women with gestational hypertension</atitle><jtitle>Journal of hypertension</jtitle><addtitle>J Hypertens</addtitle><date>2005-01</date><risdate>2005</risdate><volume>23</volume><issue>1</issue><spage>141</spage><epage>146</epage><pages>141-146</pages><issn>0263-6352</issn><eissn>1473-5598</eissn><abstract>OBJECTIVETo evaluate whether the determination of maternal plasma Factor II:C (FII:C) and mean uterine artery resistance index may be useful to early predict pre-eclampsia in patients with gestational hypertension.
DESIGNProspective study.
SETTINGConsecutive enrollment in a public tertiary clinical care centre.
PATIENTSA total of 65 women with gestational hypertension at 24–26 weeks.
INTERVENTIONMeasurements of maternal plasma FII:C activity levels, ultrasonographic biometrical parameters and Doppler velocimetry of maternal uterine arteries.
MAIN OUTCOME MEASURE(S)The probability of developing pre-eclampsia was the main outcome of the study and it was computed by combining the FII:C and the mean uterine artery resistance index cut-off points, chosen by receiver operating characteristic (ROC) curve analysis.
RESULTSF-II:C activity levels and mean uterine artery resistance index were significantly (both P < 0.01) higher in women who developed pre-eclampsia. A weak, but significant correlation (r = 0.3, P < 0.05) was found between these two parameters. FII:C activity levels at the cut-off value of 136.5% achieved a sensitivity of 61.1% and a specificity of 71.3%, while mean uterine artery resistance index (RI) at the cut-off value of 0.57 showed a sensitivity of 85.7% and a specificity of 90.2% in predicting the onset of pre-eclampsia. When both FII:C and mean uterine RI were over the cut-off points the positive predictive value was of 89%, with a 100% negative predictive value when both were below the cut-off points.
CONCLUSIONF-II:C activity levels and mean uterine artery resistance index determination at mid trimester may improve the prediction of superimposed pre-eclampsia on women with early onset gestational hypertension.</abstract><cop>England</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>15643136</pmid><doi>10.1097/00004872-200501000-00024</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of hypertension, 2005-01, Vol.23 (1), p.141-146 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Adult Biomarkers Early Diagnosis Female Humans Hypertension, Pregnancy-Induced - blood Hypertension, Pregnancy-Induced - diagnostic imaging Hypertension, Pregnancy-Induced - epidemiology Pre-Eclampsia - blood Pre-Eclampsia - diagnostic imaging Pre-Eclampsia - epidemiology Predictive Value of Tests Pregnancy Prospective Studies Prothrombin - metabolism Risk Factors ROC Curve Ultrasonography, Doppler Uterus - blood supply von Willebrand Factor |
| title | Factor II: C activity and uterine artery Doppler evaluation to improve the early prediction of pre-eclampsia on women with gestational hypertension |
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