Induction of gp120-specific protective immune responses by genetic vaccination with linear polyethylenimine–plasmid complex

The induction of IFN-γ-secreting CD8+ T cells and neutralizing antibodies to HIV-1 are both key requirements for prevention of viral transmission and clearance of pathogenic HIV. Although DNA vaccination has been shown to induce both humoral and cellular immune responses against HIV antigens, the ma...

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Veröffentlicht in:	Vaccine 2005-02, Vol.23 (11), p.1384-1392
Hauptverfasser:	Rodrigo Garzón, Manolo, Berraondo, Pedro, Crettaz, Julien, Ochoa, Laura, Vera, Maria, Lasarte, Juan Jose, Vales, Africa, Van Rooijen, Nico, Ruiz, Juan, Prieto, Jesús, Zulueta, Javier, González-Aseguinolaza, Gloria
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS AIDS Vaccines - administration & dosage AIDS Vaccines - chemistry AIDS Vaccines - immunology Animals Applied microbiology Biological and medical sciences CD8+ T cell CD8-Positive T-Lymphocytes - immunology Deoxyribonucleic acid DNA Female Fundamental and applied biological sciences. Psychology HIV HIV Antibodies - immunology HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - immunology HIV Infections - prevention & control HIV-1 - genetics HIV-1 - immunology HIV–gp120 Human immunodeficiency virus Human immunodeficiency virus 1 Immune system Immunity, Mucosal Injections, Intravenous Interferon-gamma - blood Interleukin-12 - blood Macrophage Activation Macrophages - immunology Mice Mice, Inbred BALB C Microbiology Plasmid DNA Plasmids Plasmids - administration & dosage Plasmids - genetics Plasmids - immunology Polyethyleneimine - administration & dosage Polyethyleneimine - chemistry Polyethylenimine Protection Vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, DNA - administration & dosage Vaccines, DNA - genetics Vaccines, DNA - immunology Vaccinia virus Vaccinia virus - genetics
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