Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets

We predict regulatory targets of vertebrate microRNAs (miRNAs) by identifying mRNAs with conserved complementarity to the seed (nucleotides 2–7) of the miRNA. An overrepresentation of conserved adenosines flanking the seed complementary sites in mRNAs indicates that primary sequence determinants can...

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Veröffentlicht in:	Cell 2005-01, Vol.120 (1), p.15-20
Hauptverfasser:	Lewis, Benjamin P., Burge, Christopher B., Bartel, David P.
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Adenosine - genetics Adenosine - metabolism Amino Acid Sequence Animals Chickens Dogs Gene Expression Regulation - genetics Gene Targeting - methods Humans Mice MicroRNAs - genetics Molecular Sequence Data Nucleic Acid Hybridization - physiology Nucleotides - metabolism Rats RNA, Messenger - genetics
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