Homologous recombination and RecA protein: towards a new generation of tools for genome manipulations
Homologous recombination (HR) is one of the central processes of DNA metabolism, combining roles in both cell housekeeping and the evolution of genomes. In eukaryotes, HR underlies meiosis and ensures genome stability. The complete sequencing of numerous bacterial genomes has shown that HR has a sub...
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| Veröffentlicht in: | Trends in biotechnology (Regular ed.) 2005-02, Vol.23 (2), p.97-102 |
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| creator | Volodin, Alexander A. Voloshin, Oleg N. Camerini-Otero, R. Daniel |
| description | Homologous recombination (HR) is one of the central processes of DNA metabolism, combining roles in both cell housekeeping and the evolution of genomes. In eukaryotes, HR underlies meiosis and ensures genome stability. The complete sequencing of numerous bacterial genomes has shown that HR has a substantial role in the evolution of microorganisms, especially pathogens. HR systems from different species and their isolated components are finding an expanding field of applications in modern genetic engineering and bio- and nanotechnologies. Recently, much progress has been made in our understanding of HR mechanisms in eukaryotes and the practical applications of HR systems. |
| doi_str_mv | 10.1016/j.tibtech.2004.12.005 |
| format | Article |
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Recently, much progress has been made in our understanding of HR mechanisms in eukaryotes and the practical applications of HR systems.</description><subject>Animals</subject><subject>Bacteria - genetics</subject><subject>Bacteria - metabolism</subject><subject>DNA Replication</subject><subject>Evolution, Molecular</subject><subject>Genome</subject><subject>Humans</subject><subject>Rec A Recombinases - genetics</subject><subject>Rec A Recombinases - metabolism</subject><subject>Recombination, Genetic</subject><issn>0167-7799</issn><issn>1879-3096</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctq3DAUQEVJaSZpP6FBq-zs6FqyZHVTQsgLAoHSroVsXacabGkieRry99VkBrLMSnB17vMQ8h1YDQzkxbpefL_g8LduGBM1NDVj7Seygk7pijMtj8iqcKpSSutjcpLzmjHGlYYv5BhaKYELtSJ4F-c4xae4zTThEOfeB7v4GKgNjv7C4ZJuUlzQhx90iS82uUwtDfhCnzBg2qNxLH9xynSMaRePM9LZBr_ZTm9A_ko-j3bK-O3wnpI_N9e_r-6qh8fb-6vLh2rgWixVZ0fZNAqajolRIMd2VAycaEYnnGsZKg6obWexF63sQSNyi5r1ogOU0PNTcr6vW2Z-3mJezOzzgNNkA5YNjVRcKs3lhyCojnNooYDtHhxSzDnhaDbJzza9GmBmJ8KszUGE2Ykw0JgiouSdHRps-xnde9bh8gX4uQew3OOfx2Ty4DEM6HzxsBgX_Qct_gOsDJ3L</recordid><startdate>20050201</startdate><enddate>20050201</enddate><creator>Volodin, Alexander A.</creator><creator>Voloshin, Oleg N.</creator><creator>Camerini-Otero, R. 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| fulltext | fulltext |
| identifier | ISSN: 0167-7799 |
| ispartof | Trends in biotechnology (Regular ed.), 2005-02, Vol.23 (2), p.97-102 |
| issn | 0167-7799 1879-3096 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | Animals Bacteria - genetics Bacteria - metabolism DNA Replication Evolution, Molecular Genome Humans Rec A Recombinases - genetics Rec A Recombinases - metabolism Recombination, Genetic |
| title | Homologous recombination and RecA protein: towards a new generation of tools for genome manipulations |
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