NPM Mutations in Acute Myelogenous Leukemia
Nucleophosmin (NPM) is a multifunctional phosphoprotein to which both tumor-suppressor and oncogenic functions have been attributed. Chromosomal translocations involving the NPM1 gene occur not infrequently in myeloid and lymphoid cancers. The NPM1 gene rearranges with the retinoic acid receptor α (...
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| Veröffentlicht in: | The New England journal of medicine 2005-01, Vol.352 (3), p.291-292 |
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| container_title | The New England journal of medicine |
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| creator | Grisendi, Silvia Pandolfi, Pier Paolo |
| description | Nucleophosmin (NPM) is a multifunctional phosphoprotein to which both tumor-suppressor and oncogenic functions have been attributed. Chromosomal translocations involving the
NPM1
gene occur not infrequently in myeloid and lymphoid cancers. The
NPM1
gene rearranges with the retinoic acid receptor α (
RAR
α) gene in acute promyelocytic leukemia and with the anaplastic lymphoma kinase (
ALK
) gene in a high percentage of anaplastic large-cell lymphomas. Rearrangements with the myeloid leukemia factor 1 (
MLF1
) gene occur in acute myelogenous leukemia (AML), chronic myelogenous leukemia, and myelodysplasia.
1
–
3
As a consequence of these translocations, the rearranged
NPM1
allele encodes . . . |
| doi_str_mv | 10.1056/NEJMe048337 |
| format | Article |
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NPM1
gene occur not infrequently in myeloid and lymphoid cancers. The
NPM1
gene rearranges with the retinoic acid receptor α (
RAR
α) gene in acute promyelocytic leukemia and with the anaplastic lymphoma kinase (
ALK
) gene in a high percentage of anaplastic large-cell lymphomas. Rearrangements with the myeloid leukemia factor 1 (
MLF1
) gene occur in acute myelogenous leukemia (AML), chronic myelogenous leukemia, and myelodysplasia.
1
–
3
As a consequence of these translocations, the rearranged
NPM1
allele encodes . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMe048337</identifier><identifier>PMID: 15659732</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Cytoplasm - chemistry ; Humans ; Leukemia, Myeloid, Acute - genetics ; Mutation ; Nuclear Proteins - analysis ; Nuclear Proteins - genetics ; Nuclear Proteins - physiology ; Translocation, Genetic</subject><ispartof>The New England journal of medicine, 2005-01, Vol.352 (3), p.291-292</ispartof><rights>Copyright © 2005 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-68ebe5a42b78bbb3bab9b34c92c1b89222ad8584ec8f0c31251e79f4d5cee2e3</citedby><cites>FETCH-LOGICAL-c352t-68ebe5a42b78bbb3bab9b34c92c1b89222ad8584ec8f0c31251e79f4d5cee2e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMe048337$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMe048337$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,777,781,2746,2747,26084,27905,27906,52363,54045,64366</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15659732$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grisendi, Silvia</creatorcontrib><creatorcontrib>Pandolfi, Pier Paolo</creatorcontrib><title>NPM Mutations in Acute Myelogenous Leukemia</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Nucleophosmin (NPM) is a multifunctional phosphoprotein to which both tumor-suppressor and oncogenic functions have been attributed. Chromosomal translocations involving the
NPM1
gene occur not infrequently in myeloid and lymphoid cancers. The
NPM1
gene rearranges with the retinoic acid receptor α (
RAR
α) gene in acute promyelocytic leukemia and with the anaplastic lymphoma kinase (
ALK
) gene in a high percentage of anaplastic large-cell lymphomas. Rearrangements with the myeloid leukemia factor 1 (
MLF1
) gene occur in acute myelogenous leukemia (AML), chronic myelogenous leukemia, and myelodysplasia.
1
–
3
As a consequence of these translocations, the rearranged
NPM1
allele encodes . . .</description><subject>Cytoplasm - chemistry</subject><subject>Humans</subject><subject>Leukemia, Myeloid, Acute - genetics</subject><subject>Mutation</subject><subject>Nuclear Proteins - analysis</subject><subject>Nuclear Proteins - genetics</subject><subject>Nuclear Proteins - physiology</subject><subject>Translocation, Genetic</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkDtPwzAURi0EoqUwsaNISCxVwM_YHquqvNQUhu6W7d6glDgpcTL03xPUSjBwl7scHX06CF0TfE-wyB5Wi9ccMFeMyRM0JoKxlHOcnaIxxlSlXGo2QhcxbvFwhOtzNCIiE1oyOkbT1Xue5H1nu7KpY1LWycz3HST5HqrmA-qmj8kS-k8Ipb1EZ4WtIlwd_wStHxfr-XO6fHt6mc-WqWeCdmmmwIGwnDqpnHPMWacd415TT5zSlFK7UUJx8KrAnhEqCEhd8I3wABTYBN0dtLu2-eohdiaU0UNV2RqGOSaTLJNU4AGcHkDfNjG2UJhdWwbb7g3B5ieN-ZNmoG-O2t4F2PyyxxYDcHsAQoimhm34V_MNuGxoOQ</recordid><startdate>20050120</startdate><enddate>20050120</enddate><creator>Grisendi, Silvia</creator><creator>Pandolfi, Pier Paolo</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050120</creationdate><title>NPM Mutations in Acute Myelogenous Leukemia</title><author>Grisendi, Silvia ; Pandolfi, Pier Paolo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-68ebe5a42b78bbb3bab9b34c92c1b89222ad8584ec8f0c31251e79f4d5cee2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Cytoplasm - chemistry</topic><topic>Humans</topic><topic>Leukemia, Myeloid, Acute - genetics</topic><topic>Mutation</topic><topic>Nuclear Proteins - analysis</topic><topic>Nuclear Proteins - genetics</topic><topic>Nuclear Proteins - physiology</topic><topic>Translocation, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grisendi, Silvia</creatorcontrib><creatorcontrib>Pandolfi, Pier Paolo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grisendi, Silvia</au><au>Pandolfi, Pier Paolo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NPM Mutations in Acute Myelogenous Leukemia</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2005-01-20</date><risdate>2005</risdate><volume>352</volume><issue>3</issue><spage>291</spage><epage>292</epage><pages>291-292</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>Nucleophosmin (NPM) is a multifunctional phosphoprotein to which both tumor-suppressor and oncogenic functions have been attributed. Chromosomal translocations involving the
NPM1
gene occur not infrequently in myeloid and lymphoid cancers. The
NPM1
gene rearranges with the retinoic acid receptor α (
RAR
α) gene in acute promyelocytic leukemia and with the anaplastic lymphoma kinase (
ALK
) gene in a high percentage of anaplastic large-cell lymphomas. Rearrangements with the myeloid leukemia factor 1 (
MLF1
) gene occur in acute myelogenous leukemia (AML), chronic myelogenous leukemia, and myelodysplasia.
1
–
3
As a consequence of these translocations, the rearranged
NPM1
allele encodes . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>15659732</pmid><doi>10.1056/NEJMe048337</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | The New England journal of medicine, 2005-01, Vol.352 (3), p.291-292 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Cytoplasm - chemistry Humans Leukemia, Myeloid, Acute - genetics Mutation Nuclear Proteins - analysis Nuclear Proteins - genetics Nuclear Proteins - physiology Translocation, Genetic |
| title | NPM Mutations in Acute Myelogenous Leukemia |
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