The relationship between leukoaraiosis volume and parameters of carotid artery duplex ultrasonographic scanning in asymptomatic diabetic patients
Abstract The significance of asymptomatic leukoaraiosis is unknown although cerebral microangiopathy is regarded as its pathology. To confirm the relationship between leukoaraiosis and cerebral microangiopathy, the pulsatility index (PI) at the cervical internal carotid artery (CA) which has been pr...
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| Veröffentlicht in: | Computerized medical imaging and graphics 2009-09, Vol.33 (6), p.489-493 |
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| creator | Tanaka, Tomotaka Shimizu, Tomohisa Fukuhara, Toru |
| description | Abstract The significance of asymptomatic leukoaraiosis is unknown although cerebral microangiopathy is regarded as its pathology. To confirm the relationship between leukoaraiosis and cerebral microangiopathy, the pulsatility index (PI) at the cervical internal carotid artery (CA) which has been proposed as an indicator of microangiopathy, was evaluated in relation to leukoaraiosis. With 122 asymptomatic diabetic patients, leukoaraiosis volume was calculated with magnetic resonance imaging and its correlation with age, microalbuminuria and parameters of extracranial CA duplex ultrasonographic scanning were analyzed. The leukoaraiosis volume correlated with PI on the right side ( p = 0.027), and intima-media thickness on the left ( p = 0.017). However multivariate analysis indicated that age alone was a significant independent factor, positively correlating with leukoaraiosis volume on both sides ( p < 0.0001 on both sides). The underlying pathology of leukoaraiosis should be multifactorial. Further exploration is necessary to distinguish “ischemic” and “non-ischemic” leukoaraiosis. |
| doi_str_mv | 10.1016/j.compmedimag.2009.04.007 |
| format | Article |
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To confirm the relationship between leukoaraiosis and cerebral microangiopathy, the pulsatility index (PI) at the cervical internal carotid artery (CA) which has been proposed as an indicator of microangiopathy, was evaluated in relation to leukoaraiosis. With 122 asymptomatic diabetic patients, leukoaraiosis volume was calculated with magnetic resonance imaging and its correlation with age, microalbuminuria and parameters of extracranial CA duplex ultrasonographic scanning were analyzed. The leukoaraiosis volume correlated with PI on the right side ( p = 0.027), and intima-media thickness on the left ( p = 0.017). However multivariate analysis indicated that age alone was a significant independent factor, positively correlating with leukoaraiosis volume on both sides ( p < 0.0001 on both sides). The underlying pathology of leukoaraiosis should be multifactorial. Further exploration is necessary to distinguish “ischemic” and “non-ischemic” leukoaraiosis.</description><identifier>ISSN: 0895-6111</identifier><identifier>EISSN: 1879-0771</identifier><identifier>DOI: 10.1016/j.compmedimag.2009.04.007</identifier><identifier>PMID: 19467838</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Aged ; Carotid Arteries - diagnostic imaging ; Diabetes ; Diabetes Mellitus ; Diabetic Angiopathies - complications ; Diabetic Angiopathies - diagnostic imaging ; Female ; Humans ; Internal Medicine ; Leukoaraiosis ; Leukoaraiosis - pathology ; Male ; Microangiopathy ; Middle Aged ; Other ; Pulsatile Flow - physiology ; Pulsatility index ; Ultrasonography, Doppler, Duplex ; Volumetric analysis</subject><ispartof>Computerized medical imaging and graphics, 2009-09, Vol.33 (6), p.489-493</ispartof><rights>Elsevier Ltd</rights><rights>2009 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c558t-3e2ffb158bf6fb5c26fde2bd7bedf067cc3ed63111bb606f53d3e3584f1924323</citedby><cites>FETCH-LOGICAL-c558t-3e2ffb158bf6fb5c26fde2bd7bedf067cc3ed63111bb606f53d3e3584f1924323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.compmedimag.2009.04.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19467838$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanaka, Tomotaka</creatorcontrib><creatorcontrib>Shimizu, Tomohisa</creatorcontrib><creatorcontrib>Fukuhara, Toru</creatorcontrib><title>The relationship between leukoaraiosis volume and parameters of carotid artery duplex ultrasonographic scanning in asymptomatic diabetic patients</title><title>Computerized medical imaging and graphics</title><addtitle>Comput Med Imaging Graph</addtitle><description>Abstract The significance of asymptomatic leukoaraiosis is unknown although cerebral microangiopathy is regarded as its pathology. To confirm the relationship between leukoaraiosis and cerebral microangiopathy, the pulsatility index (PI) at the cervical internal carotid artery (CA) which has been proposed as an indicator of microangiopathy, was evaluated in relation to leukoaraiosis. With 122 asymptomatic diabetic patients, leukoaraiosis volume was calculated with magnetic resonance imaging and its correlation with age, microalbuminuria and parameters of extracranial CA duplex ultrasonographic scanning were analyzed. The leukoaraiosis volume correlated with PI on the right side ( p = 0.027), and intima-media thickness on the left ( p = 0.017). However multivariate analysis indicated that age alone was a significant independent factor, positively correlating with leukoaraiosis volume on both sides ( p < 0.0001 on both sides). The underlying pathology of leukoaraiosis should be multifactorial. Further exploration is necessary to distinguish “ischemic” and “non-ischemic” leukoaraiosis.</description><subject>Aged</subject><subject>Carotid Arteries - diagnostic imaging</subject><subject>Diabetes</subject><subject>Diabetes Mellitus</subject><subject>Diabetic Angiopathies - complications</subject><subject>Diabetic Angiopathies - diagnostic imaging</subject><subject>Female</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Leukoaraiosis</subject><subject>Leukoaraiosis - pathology</subject><subject>Male</subject><subject>Microangiopathy</subject><subject>Middle Aged</subject><subject>Other</subject><subject>Pulsatile Flow - physiology</subject><subject>Pulsatility index</subject><subject>Ultrasonography, Doppler, Duplex</subject><subject>Volumetric analysis</subject><issn>0895-6111</issn><issn>1879-0771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUs2OFCEQJkbjjquvYPDibVpouqH7YmIm_iWbeHA9ExqKGWZpaKF7dR7DN5bOTKLxsp6A4vtJ1VcIvaKkooTyN8dKx3EawbhR7auakL4iTUWIeIQ2tBP9lghBH6MN6fp2yymlV-hZzkdCSE0EfYquaN9w0bFug37dHgAn8Gp2MeSDm_AA8w-AgD0sd1El5WJ2Gd9Hv4yAVTB4KsURZkgZR4u1SnF2BqtUKidslsnDT7z4OakcQ9wnNR2cxlmrEFzYYxewyqdxmuNYPDU2ThXHcpnKE8Kcn6MnVvkMLy7nNfr24f3t7tP25svHz7t3N1vdtt28ZVBbO9C2Gyy3Q6trbg3UgxEDGEu40JqB4aw0PwyccNsyw4C1XWNpXzesZtfo9Vl3SvH7AnmWo8savFcB4pIlF4yLmvQPAlnTMt433YPAEpSggq-K_RmoU8w5gZVTKlGmk6RErgnLo_wr4ZXYS9LIwi_clxeTZSj_f5iXSAtgdwZAGd69gySzLoPVRSuBnqWJ7r9s3v6jor0LTit_ByfIx7ikUNKRVOZaEvl1XbV100hftqwpPf4G4-TXiA</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Tanaka, Tomotaka</creator><creator>Shimizu, Tomohisa</creator><creator>Fukuhara, Toru</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SC</scope><scope>JQ2</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope></search><sort><creationdate>20090901</creationdate><title>The relationship between leukoaraiosis volume and parameters of carotid artery duplex ultrasonographic scanning in asymptomatic diabetic patients</title><author>Tanaka, Tomotaka ; Shimizu, Tomohisa ; Fukuhara, Toru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c558t-3e2ffb158bf6fb5c26fde2bd7bedf067cc3ed63111bb606f53d3e3584f1924323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Carotid Arteries - diagnostic imaging</topic><topic>Diabetes</topic><topic>Diabetes Mellitus</topic><topic>Diabetic Angiopathies - complications</topic><topic>Diabetic Angiopathies - diagnostic imaging</topic><topic>Female</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Leukoaraiosis</topic><topic>Leukoaraiosis - pathology</topic><topic>Male</topic><topic>Microangiopathy</topic><topic>Middle Aged</topic><topic>Other</topic><topic>Pulsatile Flow - physiology</topic><topic>Pulsatility index</topic><topic>Ultrasonography, Doppler, Duplex</topic><topic>Volumetric analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanaka, Tomotaka</creatorcontrib><creatorcontrib>Shimizu, Tomohisa</creatorcontrib><creatorcontrib>Fukuhara, Toru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>ProQuest Computer Science Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Computerized medical imaging and graphics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanaka, Tomotaka</au><au>Shimizu, Tomohisa</au><au>Fukuhara, Toru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between leukoaraiosis volume and parameters of carotid artery duplex ultrasonographic scanning in asymptomatic diabetic patients</atitle><jtitle>Computerized medical imaging and graphics</jtitle><addtitle>Comput Med Imaging Graph</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>33</volume><issue>6</issue><spage>489</spage><epage>493</epage><pages>489-493</pages><issn>0895-6111</issn><eissn>1879-0771</eissn><abstract>Abstract The significance of asymptomatic leukoaraiosis is unknown although cerebral microangiopathy is regarded as its pathology. To confirm the relationship between leukoaraiosis and cerebral microangiopathy, the pulsatility index (PI) at the cervical internal carotid artery (CA) which has been proposed as an indicator of microangiopathy, was evaluated in relation to leukoaraiosis. With 122 asymptomatic diabetic patients, leukoaraiosis volume was calculated with magnetic resonance imaging and its correlation with age, microalbuminuria and parameters of extracranial CA duplex ultrasonographic scanning were analyzed. The leukoaraiosis volume correlated with PI on the right side ( p = 0.027), and intima-media thickness on the left ( p = 0.017). However multivariate analysis indicated that age alone was a significant independent factor, positively correlating with leukoaraiosis volume on both sides ( p < 0.0001 on both sides). The underlying pathology of leukoaraiosis should be multifactorial. Further exploration is necessary to distinguish “ischemic” and “non-ischemic” leukoaraiosis.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>19467838</pmid><doi>10.1016/j.compmedimag.2009.04.007</doi><tpages>5</tpages></addata></record> |
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| ispartof | Computerized medical imaging and graphics, 2009-09, Vol.33 (6), p.489-493 |
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| subjects | Aged Carotid Arteries - diagnostic imaging Diabetes Diabetes Mellitus Diabetic Angiopathies - complications Diabetic Angiopathies - diagnostic imaging Female Humans Internal Medicine Leukoaraiosis Leukoaraiosis - pathology Male Microangiopathy Middle Aged Other Pulsatile Flow - physiology Pulsatility index Ultrasonography, Doppler, Duplex Volumetric analysis |
| title | The relationship between leukoaraiosis volume and parameters of carotid artery duplex ultrasonographic scanning in asymptomatic diabetic patients |
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