Carbapenem antibiotic biosynthesis in Erwinia carotovora is regulated by physiological and genetic factors modulating the quorum sensing‐dependent control pathway

Summary Erwinia carotovora produces the β‐lactam antibiotic, carbapenem, in response to a quorum sensing signalling molecule, N‐(3‐oxohexanoyl)‐ l‐homoserine lactone (OHHL). We have mapped the OHHL‐dependent promoter upstream of the first of the biosynthetic genes, carA. We have also analysed the ef...

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Veröffentlicht in:	Molecular microbiology 2005-01, Vol.55 (2), p.526-545
Hauptverfasser:	McGowan, Simon J., Barnard, Anne M. L., Bosgelmez, Gulgun, Sebaihia, Mohammed, Simpson, Natalie J. L., Thomson, Nicholas R., Todd, Daniel E., Welch, Martin, Whitehead, Neil A., Salmond, George P. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Butyrolactone - analogs & derivatives 4-Butyrolactone - metabolism Antibiotics Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Biological and medical sciences Carbapenems - biosynthesis Carbon - metabolism Culture Media Erwinia carotovora Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation, Bacterial Genetics Microbiology Miscellaneous Molecular biology Operon Oxygen - pharmacology Pectobacterium carotovorum - genetics Pectobacterium carotovorum - growth & development Pectobacterium carotovorum - metabolism Pectobacterium carotovorum - physiology Promoter Regions, Genetic Signal Transduction Temperature Transcription, Genetic
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