CD45 recruits adapter protein DOK-1 and negatively regulates JAK–STAT signaling in hematopoietic cells

It has been extensively documented that CD45 positively regulates T cell receptor-mediated signaling through the activation of Src-family kinases. The mechanism whereby CD45 negatively regulates the JAK/STAT pathway, however, has not been fully elucidated. Here we describe the mechanism by which CD4...

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Veröffentlicht in:	Molecular immunology 2009-07, Vol.46 (11), p.2167-2177
Hauptverfasser:	Wu, Liangtang, Bijian, Krikor, Shen, Shi-Shiang
Format:	Artikel
Sprache:	eng
Schlagworte:	CD45 Cell Membrane - metabolism DNA-Binding Proteins - metabolism DOK-1 Humans Interferon-alpha - metabolism Interferon-alpha - pharmacology Interleukin-3 - metabolism Interleukin-3 - pharmacology JAKs Janus Kinase 2 - metabolism Jurkat Cells K562 Cells Leukocyte Common Antigens - genetics Leukocyte Common Antigens - physiology MAP Kinase Signaling System - physiology Mutation Negative regulation Phosphoproteins - metabolism Phosphorylation Protein Binding RNA-Binding Proteins - metabolism Signal Transduction STAT3 Transcription Factor - metabolism STAT5 Transcription Factor - metabolism STATs T-cells T-Lymphocytes - metabolism
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