Critical role of heme oxygenase-1 in Foxp3-mediated immune suppression

Foxp3, which encodes the transcription factor scurfin, is indispensable for the development and function of CD4 +CD25 + regulatory T cells (Treg). Recent data suggest conversion of peripheral CD4 +CD25 − naı¨ve T cells to CD4 +CD25 + Treg by acquisition of Foxp3 through costimulation with TCR and TG...

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Veröffentlicht in:	Biochemical and biophysical research communications 2005-02, Vol.327 (4), p.1066-1071
Hauptverfasser:	Choi, Byung-Min, Pae, Hyun-Ock, Jeong, Young-Ran, Kim, Young-Myeong, Chung, Hun-Taeg
Format:	Artikel
Sprache:	eng
Schlagworte:	CD4-Positive T-Lymphocytes - immunology Cell Proliferation DNA-Binding Proteins - genetics DNA-Binding Proteins - immunology DNA-Binding Proteins - metabolism Forkhead Transcription Factors Foxp3 Gene Expression Regulation, Leukemic Heme oxygenase Heme Oxygenase (Decyclizing) - genetics Heme Oxygenase (Decyclizing) - metabolism Heme Oxygenase-1 Humans Immune suppression Immune Tolerance - immunology Jurkat Cells Membrane Proteins Receptors, Interleukin-2 - immunology T cells Transfection
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