lin-17/Frizzled and lin-18 regulate POP-1/TCF-1 localization and cell type specification during C. elegans vulval development
The Caenorhabditis elegans vulva is comprised of highly similar anterior and posterior halves that are arranged in a mirror symmetric pattern. The cell lineages that form each half of the vulva are identical, except that they occur in opposite orientations with respect to the anterior/posterior axis...
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| Veröffentlicht in: | Developmental biology 2005-02, Vol.278 (1), p.118-129 |
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| container_title | Developmental biology |
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| creator | Deshpande, Rashmi Inoue, Takao Priess, James R. Hill, Russell J. |
| description | The
Caenorhabditis elegans vulva is comprised of highly similar anterior and posterior halves that are arranged in a mirror symmetric pattern. The cell lineages that form each half of the vulva are identical, except that they occur in opposite orientations with respect to the anterior/posterior axis. We show that most vulval cell divisions produce sister cells that have asymmetric levels of POP-1 and that the asymmetry has opposite orientations in the two halves of the vulva. We demonstrate that
lin-17 (Frizzled type Wnt receptor) and
lin-18 (Ryk) regulate the pattern of POP-1 localization and cell type specification in the posterior half of the vulva. In the absence of
lin-17 and
lin-18, posterior lineages are reversed and resemble anterior lineages. These experiments suggest that Wnt signaling pathways reorient cell lineages in the posterior half of the vulva from a default orientation displayed in the anterior half of the vulva. |
| doi_str_mv | 10.1016/j.ydbio.2004.10.020 |
| format | Article |
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Caenorhabditis elegans vulva is comprised of highly similar anterior and posterior halves that are arranged in a mirror symmetric pattern. The cell lineages that form each half of the vulva are identical, except that they occur in opposite orientations with respect to the anterior/posterior axis. We show that most vulval cell divisions produce sister cells that have asymmetric levels of POP-1 and that the asymmetry has opposite orientations in the two halves of the vulva. We demonstrate that
lin-17 (Frizzled type Wnt receptor) and
lin-18 (Ryk) regulate the pattern of POP-1 localization and cell type specification in the posterior half of the vulva. In the absence of
lin-17 and
lin-18, posterior lineages are reversed and resemble anterior lineages. These experiments suggest that Wnt signaling pathways reorient cell lineages in the posterior half of the vulva from a default orientation displayed in the anterior half of the vulva.</description><identifier>ISSN: 0012-1606</identifier><identifier>EISSN: 1095-564X</identifier><identifier>DOI: 10.1016/j.ydbio.2004.10.020</identifier><identifier>PMID: 15649465</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; C. elegans ; Caenorhabditis elegans ; Caenorhabditis elegans - genetics ; Caenorhabditis elegans - growth & development ; Caenorhabditis elegans - metabolism ; Caenorhabditis elegans Proteins - genetics ; Caenorhabditis elegans Proteins - metabolism ; Cell Differentiation ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Female ; Frizzled ; Genes, Helminth ; High Mobility Group Proteins - genetics ; High Mobility Group Proteins - metabolism ; Immunohistochemistry ; Intercellular Signaling Peptides and Proteins - genetics ; Intercellular Signaling Peptides and Proteins - metabolism ; Mutation ; Polarity ; Receptor Protein-Tyrosine Kinases - genetics ; Receptor Protein-Tyrosine Kinases - metabolism ; Receptors, G-Protein-Coupled - genetics ; Receptors, G-Protein-Coupled - metabolism ; Ryk ; Signal Transduction ; TCF-1 ; Vulva - cytology ; Vulva - growth & development ; Vulva - metabolism ; Wnt ; Wnt Proteins</subject><ispartof>Developmental biology, 2005-02, Vol.278 (1), p.118-129</ispartof><rights>2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-d4d4792d90748a5c0d22c9a9ceff4968a2e6c71bf3471cf1b41f28c1b4069ed53</citedby><cites>FETCH-LOGICAL-c499t-d4d4792d90748a5c0d22c9a9ceff4968a2e6c71bf3471cf1b41f28c1b4069ed53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0012160604007729$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15649465$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deshpande, Rashmi</creatorcontrib><creatorcontrib>Inoue, Takao</creatorcontrib><creatorcontrib>Priess, James R.</creatorcontrib><creatorcontrib>Hill, Russell J.</creatorcontrib><title>lin-17/Frizzled and lin-18 regulate POP-1/TCF-1 localization and cell type specification during C. elegans vulval development</title><title>Developmental biology</title><addtitle>Dev Biol</addtitle><description>The
Caenorhabditis elegans vulva is comprised of highly similar anterior and posterior halves that are arranged in a mirror symmetric pattern. The cell lineages that form each half of the vulva are identical, except that they occur in opposite orientations with respect to the anterior/posterior axis. We show that most vulval cell divisions produce sister cells that have asymmetric levels of POP-1 and that the asymmetry has opposite orientations in the two halves of the vulva. We demonstrate that
lin-17 (Frizzled type Wnt receptor) and
lin-18 (Ryk) regulate the pattern of POP-1 localization and cell type specification in the posterior half of the vulva. In the absence of
lin-17 and
lin-18, posterior lineages are reversed and resemble anterior lineages. These experiments suggest that Wnt signaling pathways reorient cell lineages in the posterior half of the vulva from a default orientation displayed in the anterior half of the vulva.</description><subject>Animals</subject><subject>C. elegans</subject><subject>Caenorhabditis elegans</subject><subject>Caenorhabditis elegans - genetics</subject><subject>Caenorhabditis elegans - growth & development</subject><subject>Caenorhabditis elegans - metabolism</subject><subject>Caenorhabditis elegans Proteins - genetics</subject><subject>Caenorhabditis elegans Proteins - metabolism</subject><subject>Cell Differentiation</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Female</subject><subject>Frizzled</subject><subject>Genes, Helminth</subject><subject>High Mobility Group Proteins - genetics</subject><subject>High Mobility Group Proteins - metabolism</subject><subject>Immunohistochemistry</subject><subject>Intercellular Signaling Peptides and Proteins - genetics</subject><subject>Intercellular Signaling Peptides and Proteins - metabolism</subject><subject>Mutation</subject><subject>Polarity</subject><subject>Receptor Protein-Tyrosine Kinases - genetics</subject><subject>Receptor Protein-Tyrosine Kinases - metabolism</subject><subject>Receptors, G-Protein-Coupled - genetics</subject><subject>Receptors, G-Protein-Coupled - metabolism</subject><subject>Ryk</subject><subject>Signal Transduction</subject><subject>TCF-1</subject><subject>Vulva - cytology</subject><subject>Vulva - growth & development</subject><subject>Vulva - metabolism</subject><subject>Wnt</subject><subject>Wnt Proteins</subject><issn>0012-1606</issn><issn>1095-564X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r4zAQhkXZ0qZpf8HCotPe7IxsWbYOe1hCsy0E2kMX9iYUaRwUFNsr2YEE-t_X-YC9tQcx8OqZGaGHkK8MUgZMzDbp3q5cm2YAfExSyOCKTBjIIikE__OFTABYljAB4pbcxbgBgLyq8htyy0ZAclFMyLt3TcLK2SK4w8Gjpbqx9JRVNOB68LpH-vrymrDZ23yRMOpbo7076N61zQk26D3t9x3S2KFxtTPnOzsE16zpPKXoca2bSHeD32lPLe7Qt90Wm_6eXNfaR3y41Cn5vXh8mz8ly5dfz_Ofy8RwKfvEcstLmVkJJa90YcBmmZFaGqxrLkWlMxSmZKs65yUzNVtxVmeVGSsIibbIp-T7eW4X2r8Dxl5tXTw-XDfYDlGJMhe8yqtPQVaWImfjmZL8DJrQxhiwVl1wWx32ioE66lEbddKjjnqO4ahn7Pp2GT-stmj_91x8jMCPM4Djb-wcBhWNw8agdQFNr2zrPlzwDznyoa8</recordid><startdate>20050201</startdate><enddate>20050201</enddate><creator>Deshpande, Rashmi</creator><creator>Inoue, Takao</creator><creator>Priess, James R.</creator><creator>Hill, Russell J.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20050201</creationdate><title>lin-17/Frizzled and lin-18 regulate POP-1/TCF-1 localization and cell type specification during C. elegans vulval development</title><author>Deshpande, Rashmi ; 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Caenorhabditis elegans vulva is comprised of highly similar anterior and posterior halves that are arranged in a mirror symmetric pattern. The cell lineages that form each half of the vulva are identical, except that they occur in opposite orientations with respect to the anterior/posterior axis. We show that most vulval cell divisions produce sister cells that have asymmetric levels of POP-1 and that the asymmetry has opposite orientations in the two halves of the vulva. We demonstrate that
lin-17 (Frizzled type Wnt receptor) and
lin-18 (Ryk) regulate the pattern of POP-1 localization and cell type specification in the posterior half of the vulva. In the absence of
lin-17 and
lin-18, posterior lineages are reversed and resemble anterior lineages. These experiments suggest that Wnt signaling pathways reorient cell lineages in the posterior half of the vulva from a default orientation displayed in the anterior half of the vulva.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15649465</pmid><doi>10.1016/j.ydbio.2004.10.020</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Developmental biology, 2005-02, Vol.278 (1), p.118-129 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals C. elegans Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - growth & development Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cell Differentiation DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female Frizzled Genes, Helminth High Mobility Group Proteins - genetics High Mobility Group Proteins - metabolism Immunohistochemistry Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Mutation Polarity Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Ryk Signal Transduction TCF-1 Vulva - cytology Vulva - growth & development Vulva - metabolism Wnt Wnt Proteins |
| title | lin-17/Frizzled and lin-18 regulate POP-1/TCF-1 localization and cell type specification during C. elegans vulval development |
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