Relevance and mechanism of oxysterol stereospecifity in coronary artery disease

Cholesterol oxidation products (oxysterols) are markers for in vitro LDL oxidation. They are potent inducers of programmed cell death and are also found in high concentrations inside atherosclerotic lesions. Among physiologically occurring oxysterols, 7β-OH-cholesterol suggests an increase of lipid...

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Veröffentlicht in:	Free radical biology & medicine 2005-02, Vol.38 (4), p.535-544
Hauptverfasser:	Rimner, Andreas, Al Makdessi, Samar, Sweidan, Hicham, Wischhusen, Jörg, Rabenstein, Björn, Shatat, Khaula, Mayer, Petra, Spyridopoulos, Ioakim
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Atherosclerosis Caspase 3 Caspases - metabolism Cell Death - drug effects Cell Extracts Cells, Cultured Cholesterol - chemistry Cholesterol - metabolism Cholesterol - pharmacology Coronary Artery Disease - metabolism Coronary Artery Disease - pathology Cytochrome c Cytochromes c - secretion Enzyme Activation - drug effects Female Free radicals Human endothelial cells Humans Male Middle Aged Mitochondria - drug effects Mitochondria - secretion Oxidation-Reduction Oxysterols Static Electricity Stereoisomerism Stereospecificity Substrate Specificity
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