T280M and V249I polymorphisms of fractalkine receptor CX3CR1 and ischemic cerebrovascular disease
The contribution to atherosclerosis of two CX3CR1 single nucleotide polymorphisms, V249I and T280M has been recently reported. The atherosclerosis of intracranial vessels is thought to be the major pathological mechanism of ischemic stroke. In this study, we investigated the risk of ischemic stroke...
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| Veröffentlicht in: | Neuroscience letters 2005-02, Vol.374 (2), p.132-135 |
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| container_title | Neuroscience letters |
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| creator | Hattori, Hidenori Ito, Daisuke Tanahashi, Norio Murata, Mitsuru Saito, Ikuo Watanabe, Kiyoaki Suzuki, Norihiro |
| description | The contribution to atherosclerosis of two CX3CR1 single nucleotide polymorphisms, V249I and T280M has been recently reported. The atherosclerosis of intracranial vessels is thought to be the major pathological mechanism of ischemic stroke. In this study, we investigated the risk of ischemic stroke associated with fractalkine receptor CX3CR1 polymorphisms.
We investigated the T280M and V249I mutations in the CX3CR1 gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 306 age- and sex-matched healthy controls. Polymerase chain reaction and restriction fragment length polymorphism were used for genotyping.
There was no significant difference in both polymorphisms between patients with ischemic CVD and controls (VV versus II
+
VI,
p
=
0.83; TT versus MM
+
TM,
p
=
0.66). The I and M allele frequencies were not significantly different between CVD patients and controls: odds ratio (OR)
=
0.89 (95% confidence interval (CI)
=
0.50–1.60,
p
=
0.70) and OR
=
1.19 (95% CI
=
0.71–2.00,
p
=
0.51), respectively. We found eight of nine possible combined genotypes, including a new haplotype V249-M280, in Japanese.
Our results show that these CX3CR1 gene polymorphisms are not associated with an increased risk for ischemic CVD in the Japanese population. |
| doi_str_mv | 10.1016/j.neulet.2004.10.042 |
| format | Article |
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We investigated the T280M and V249I mutations in the CX3CR1 gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 306 age- and sex-matched healthy controls. Polymerase chain reaction and restriction fragment length polymorphism were used for genotyping.
There was no significant difference in both polymorphisms between patients with ischemic CVD and controls (VV versus II
+
VI,
p
=
0.83; TT versus MM
+
TM,
p
=
0.66). The I and M allele frequencies were not significantly different between CVD patients and controls: odds ratio (OR)
=
0.89 (95% confidence interval (CI)
=
0.50–1.60,
p
=
0.70) and OR
=
1.19 (95% CI
=
0.71–2.00,
p
=
0.51), respectively. We found eight of nine possible combined genotypes, including a new haplotype V249-M280, in Japanese.
Our results show that these CX3CR1 gene polymorphisms are not associated with an increased risk for ischemic CVD in the Japanese population.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2004.10.042</identifier><identifier>PMID: 15644279</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Atherosclerosis ; Biological and medical sciences ; Case-Control Studies ; Cerebrovascular Disorders - genetics ; Confidence Intervals ; CX3C Chemokine Receptor 1 ; CX3CR1 ; Female ; Fractalkine ; Fundamental and applied biological sciences. Psychology ; Gene Frequency ; Genotype ; Humans ; Ischemic stroke ; Isoleucine - genetics ; Male ; Medical sciences ; Membrane Proteins - genetics ; Methionine - genetics ; Middle Aged ; Neurology ; Odds Ratio ; Polymorphism ; Polymorphism, Single Nucleotide - genetics ; Receptors, Chemokine - genetics ; Reverse Transcriptase Polymerase Chain Reaction - methods ; Risk Factors ; Threonine - genetics ; Valine - genetics ; Vascular diseases and vascular malformations of the nervous system ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2005-02, Vol.374 (2), p.132-135</ispartof><rights>2004 Elsevier Ireland Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-cf6fcd73a8f1432176cf92621b208967597fbe0d814b150be3485ca4422a81333</citedby><cites>FETCH-LOGICAL-c456t-cf6fcd73a8f1432176cf92621b208967597fbe0d814b150be3485ca4422a81333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304394004013187$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16426348$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15644279$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hattori, Hidenori</creatorcontrib><creatorcontrib>Ito, Daisuke</creatorcontrib><creatorcontrib>Tanahashi, Norio</creatorcontrib><creatorcontrib>Murata, Mitsuru</creatorcontrib><creatorcontrib>Saito, Ikuo</creatorcontrib><creatorcontrib>Watanabe, Kiyoaki</creatorcontrib><creatorcontrib>Suzuki, Norihiro</creatorcontrib><title>T280M and V249I polymorphisms of fractalkine receptor CX3CR1 and ischemic cerebrovascular disease</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>The contribution to atherosclerosis of two CX3CR1 single nucleotide polymorphisms, V249I and T280M has been recently reported. The atherosclerosis of intracranial vessels is thought to be the major pathological mechanism of ischemic stroke. In this study, we investigated the risk of ischemic stroke associated with fractalkine receptor CX3CR1 polymorphisms.
We investigated the T280M and V249I mutations in the CX3CR1 gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 306 age- and sex-matched healthy controls. Polymerase chain reaction and restriction fragment length polymorphism were used for genotyping.
There was no significant difference in both polymorphisms between patients with ischemic CVD and controls (VV versus II
+
VI,
p
=
0.83; TT versus MM
+
TM,
p
=
0.66). The I and M allele frequencies were not significantly different between CVD patients and controls: odds ratio (OR)
=
0.89 (95% confidence interval (CI)
=
0.50–1.60,
p
=
0.70) and OR
=
1.19 (95% CI
=
0.71–2.00,
p
=
0.51), respectively. We found eight of nine possible combined genotypes, including a new haplotype V249-M280, in Japanese.
Our results show that these CX3CR1 gene polymorphisms are not associated with an increased risk for ischemic CVD in the Japanese population.</description><subject>Atherosclerosis</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Cerebrovascular Disorders - genetics</subject><subject>Confidence Intervals</subject><subject>CX3C Chemokine Receptor 1</subject><subject>CX3CR1</subject><subject>Female</subject><subject>Fractalkine</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Humans</subject><subject>Ischemic stroke</subject><subject>Isoleucine - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Proteins - genetics</subject><subject>Methionine - genetics</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Odds Ratio</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Receptors, Chemokine - genetics</subject><subject>Reverse Transcriptase Polymerase Chain Reaction - methods</subject><subject>Risk Factors</subject><subject>Threonine - genetics</subject><subject>Valine - genetics</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVp6G4-_kEpurQ3b_Rlyb4UypKmCymBkITchCyPiLa25Ur2Qv59tN2FvfU0MDzv8M6D0GdKVpRQeb1dDTB3MK0YISKvVkSwD2hJK8UKVSv2ES0JJ6LgtSALdJ7SlhBS0lJ8QgtaSiGYqpfIPLKK_MZmaPEzE_UGj6F760McX33qEw4Ou2jsZLo_fgAcwcI4hYjXL3z9QP_FfLKv0HuLLURoYtiZZOfORNz6BCbBJTpzpktwdZwX6OnnzeP6V3F3f7tZ_7grrCjlVFgnnW0VN5WjgjOqpHU1k4w2jFS1VGWtXAOkrahoaEka4KIqrclvMFNRzvkF-na4O8bwd4Y06T5Xg64zA4Q5aam4ZJzSDIoDaGNIKYLTY_S9iW-aEr1Xq7f6oFbv1e63WW2OfTnen5se2lPo6DIDX49ANmC67G2wPp04KZjMpTP3_cBBtrHzEHWyHgYLrc9-J90G__8m74uPl4w</recordid><startdate>20050210</startdate><enddate>20050210</enddate><creator>Hattori, Hidenori</creator><creator>Ito, Daisuke</creator><creator>Tanahashi, Norio</creator><creator>Murata, Mitsuru</creator><creator>Saito, Ikuo</creator><creator>Watanabe, Kiyoaki</creator><creator>Suzuki, Norihiro</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050210</creationdate><title>T280M and V249I polymorphisms of fractalkine receptor CX3CR1 and ischemic cerebrovascular disease</title><author>Hattori, Hidenori ; Ito, Daisuke ; Tanahashi, Norio ; Murata, Mitsuru ; Saito, Ikuo ; Watanabe, Kiyoaki ; Suzuki, Norihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-cf6fcd73a8f1432176cf92621b208967597fbe0d814b150be3485ca4422a81333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Atherosclerosis</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Cerebrovascular Disorders - genetics</topic><topic>Confidence Intervals</topic><topic>CX3C Chemokine Receptor 1</topic><topic>CX3CR1</topic><topic>Female</topic><topic>Fractalkine</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Humans</topic><topic>Ischemic stroke</topic><topic>Isoleucine - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Proteins - genetics</topic><topic>Methionine - genetics</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Odds Ratio</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Receptors, Chemokine - genetics</topic><topic>Reverse Transcriptase Polymerase Chain Reaction - methods</topic><topic>Risk Factors</topic><topic>Threonine - genetics</topic><topic>Valine - genetics</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hattori, Hidenori</creatorcontrib><creatorcontrib>Ito, Daisuke</creatorcontrib><creatorcontrib>Tanahashi, Norio</creatorcontrib><creatorcontrib>Murata, Mitsuru</creatorcontrib><creatorcontrib>Saito, Ikuo</creatorcontrib><creatorcontrib>Watanabe, Kiyoaki</creatorcontrib><creatorcontrib>Suzuki, Norihiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hattori, Hidenori</au><au>Ito, Daisuke</au><au>Tanahashi, Norio</au><au>Murata, Mitsuru</au><au>Saito, Ikuo</au><au>Watanabe, Kiyoaki</au><au>Suzuki, Norihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T280M and V249I polymorphisms of fractalkine receptor CX3CR1 and ischemic cerebrovascular disease</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2005-02-10</date><risdate>2005</risdate><volume>374</volume><issue>2</issue><spage>132</spage><epage>135</epage><pages>132-135</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>The contribution to atherosclerosis of two CX3CR1 single nucleotide polymorphisms, V249I and T280M has been recently reported. The atherosclerosis of intracranial vessels is thought to be the major pathological mechanism of ischemic stroke. In this study, we investigated the risk of ischemic stroke associated with fractalkine receptor CX3CR1 polymorphisms.
We investigated the T280M and V249I mutations in the CX3CR1 gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 306 age- and sex-matched healthy controls. Polymerase chain reaction and restriction fragment length polymorphism were used for genotyping.
There was no significant difference in both polymorphisms between patients with ischemic CVD and controls (VV versus II
+
VI,
p
=
0.83; TT versus MM
+
TM,
p
=
0.66). The I and M allele frequencies were not significantly different between CVD patients and controls: odds ratio (OR)
=
0.89 (95% confidence interval (CI)
=
0.50–1.60,
p
=
0.70) and OR
=
1.19 (95% CI
=
0.71–2.00,
p
=
0.51), respectively. We found eight of nine possible combined genotypes, including a new haplotype V249-M280, in Japanese.
Our results show that these CX3CR1 gene polymorphisms are not associated with an increased risk for ischemic CVD in the Japanese population.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>15644279</pmid><doi>10.1016/j.neulet.2004.10.042</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 2005-02, Vol.374 (2), p.132-135 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Atherosclerosis Biological and medical sciences Case-Control Studies Cerebrovascular Disorders - genetics Confidence Intervals CX3C Chemokine Receptor 1 CX3CR1 Female Fractalkine Fundamental and applied biological sciences. Psychology Gene Frequency Genotype Humans Ischemic stroke Isoleucine - genetics Male Medical sciences Membrane Proteins - genetics Methionine - genetics Middle Aged Neurology Odds Ratio Polymorphism Polymorphism, Single Nucleotide - genetics Receptors, Chemokine - genetics Reverse Transcriptase Polymerase Chain Reaction - methods Risk Factors Threonine - genetics Valine - genetics Vascular diseases and vascular malformations of the nervous system Vertebrates: nervous system and sense organs |
| title | T280M and V249I polymorphisms of fractalkine receptor CX3CR1 and ischemic cerebrovascular disease |
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