Quantitative Structure−Activity Relationship (5D-QSAR) Study of Combretastatin-like Analogues as Inhibitors of Tubulin Assembly

A molecular modeling study was carried out to develop a predictive model for combretastatin-like analogues populating the colchicine-binding site of β-tubulin. A series of compounds built around a framework including two aromatic groups linked by various moieties such as alkenes (stilbenes), enones...

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Veröffentlicht in:	Journal of medicinal chemistry 2005-01, Vol.48 (2), p.457-465
Hauptverfasser:	Ducki, Sylvie, Mackenzie, Grant, Lawrence, Nicholas J, Snyder, James P
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Bibenzyls - chemistry Binding Sites Colchicine - chemistry Ligands Models, Molecular Molecular Conformation Monte Carlo Method Quantitative Structure-Activity Relationship Stilbenes - chemistry Tubulin - chemistry Tubulin Modulators
Online-Zugang:	Volltext
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