Serum concentrations of interferon-γ and intercellular adhesion molecule-1 eight years after an early respiratory syncytial virus infection
Summary Background Respiratory syncytial virus (RSV) infection may influence the development of recurrent wheezing and atopy, but the mechanisms are unclear. Objective The purpose was to evaluate serum concentrations of soluble intercellular adhesion molecule‐1 (sICAM‐1), CD14, IgE, IL‐5 and IFN‐γ i...
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| Veröffentlicht in: | Clinical and experimental allergy 2005-01, Vol.35 (1), p.59-63 |
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| creator | Juntti, H. Kokkonen, J. Dunder, T. Renko, M. Karttunen, R. Uhari, M. |
| description | Summary
Background
Respiratory syncytial virus (RSV) infection may influence the development of recurrent wheezing and atopy, but the mechanisms are unclear.
Objective
The purpose was to evaluate serum concentrations of soluble intercellular adhesion molecule‐1 (sICAM‐1), CD14, IgE, IL‐5 and IFN‐γ in children 6–10 years after an RSV infection and their correlation with subsequent asthma and atopy.
Methods
Fifty‐one subjects admitted to hospital for RSV infection during the first year of life and controls matched for birth date and sex underwent clinical examinations including lung function, skin prick and blood tests.
Results
The RSV subjects had significantly higher serum concentrations of IFN‐γ and sICAM‐1 than the controls (for IFN‐γ 224.9 pg/mL (standard deviation (SD) 271.3) vs. 187.1 pg/mL (372.9), difference 37.8 pg/mL, 95% confidence interval (CI) −90.3 to 166.0, P=0.05; for sICAM‐1 170.2 ng/mL (SD 63) vs. 147.8 ng/mL (SD 57), difference 22.4 ng/mL, 95% CI −1.4 to 46.1, P=0.04). The RSV subjects with asthma had significantly higher concentrations of IFN‐γ than the controls with asthma, and the RSV subjects with wheezing during the previous 12 months had significantly higher concentrations of both IFN‐γ and sICAM‐1 than the controls with wheezing.
Conclusions
Children hospitalized for RSV infection in infancy still differ in IFN‐γ and sICAM‐1 production 6–10 years after the infection. The data suggest that the pathomechanism of asthma and wheezing after an early RSV infection may be different from that of children without an early RSV infection. |
| doi_str_mv | 10.1111/j.1365-2222.2004.02125.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67361366</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17866020</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4665-3447e6ec15ad1c56ef90f88c5f2d208cb0ff94c2e8fdeeea092ab84252f84d1d3</originalsourceid><addsrcrecordid>eNqNkU2O1DAQhS0EYpqBKyBvYJdgO7bjLFiMWkODNAIhBiGxsdxOmXHjTho7gc4duA334Ew4pDWzhNr473tVrnoIYUpKmuPFrqSVFAXLUTJCeEkYZaI83kOr24f7aEUawYtaNfwMPUppRwipRKMeojMqJG-YrFfo5weI4x7bvrPQDdEMvu8S7h323QDRQey74vcvbLp2ubEQwhhMxKa9gZRhvO8D2DFAQTH4LzcDnsDEhI3LdNbhfAoTjpAOPqfv44TT1Nlp8Cbg7z6OKSd2YOfCj9EDZ0KCJ6f1HH18dXm9fl1cvdu8WV9cFZbL3F3FeQ0SLBWmpVZIcA1xSlnhWMuIslviXMMtA-VaADCkYWarOBPMKd7StjpHz5e8h9h_GyENeu_T3JnpoB-TlnUl8xzlP0FaKykJIxlUC2hjn1IEpw_R702cNCV6tkzv9OyMnp3Rs2X6r2X6mKVPTzXG7R7aO-HJoww8OwEmWRNcNJ316Y6TXCrasMy9XLgfPsD03x_Q68uLeZf1xaL3aYDjrd7Er_NAaqE_vd1ovq7e19f8s95UfwCMbMV1</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17866020</pqid></control><display><type>article</type><title>Serum concentrations of interferon-γ and intercellular adhesion molecule-1 eight years after an early respiratory syncytial virus infection</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Juntti, H. ; Kokkonen, J. ; Dunder, T. ; Renko, M. ; Karttunen, R. ; Uhari, M.</creator><creatorcontrib>Juntti, H. ; Kokkonen, J. ; Dunder, T. ; Renko, M. ; Karttunen, R. ; Uhari, M.</creatorcontrib><description>Summary
Background
Respiratory syncytial virus (RSV) infection may influence the development of recurrent wheezing and atopy, but the mechanisms are unclear.
Objective
The purpose was to evaluate serum concentrations of soluble intercellular adhesion molecule‐1 (sICAM‐1), CD14, IgE, IL‐5 and IFN‐γ in children 6–10 years after an RSV infection and their correlation with subsequent asthma and atopy.
Methods
Fifty‐one subjects admitted to hospital for RSV infection during the first year of life and controls matched for birth date and sex underwent clinical examinations including lung function, skin prick and blood tests.
Results
The RSV subjects had significantly higher serum concentrations of IFN‐γ and sICAM‐1 than the controls (for IFN‐γ 224.9 pg/mL (standard deviation (SD) 271.3) vs. 187.1 pg/mL (372.9), difference 37.8 pg/mL, 95% confidence interval (CI) −90.3 to 166.0, P=0.05; for sICAM‐1 170.2 ng/mL (SD 63) vs. 147.8 ng/mL (SD 57), difference 22.4 ng/mL, 95% CI −1.4 to 46.1, P=0.04). The RSV subjects with asthma had significantly higher concentrations of IFN‐γ than the controls with asthma, and the RSV subjects with wheezing during the previous 12 months had significantly higher concentrations of both IFN‐γ and sICAM‐1 than the controls with wheezing.
Conclusions
Children hospitalized for RSV infection in infancy still differ in IFN‐γ and sICAM‐1 production 6–10 years after the infection. The data suggest that the pathomechanism of asthma and wheezing after an early RSV infection may be different from that of children without an early RSV infection.</description><identifier>ISSN: 0954-7894</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1111/j.1365-2222.2004.02125.x</identifier><identifier>PMID: 15649267</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Allergic diseases ; Asthma - immunology ; atopy ; Biological and medical sciences ; Case-Control Studies ; Chi-Square Distribution ; Child ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; IFN-γ ; Immunoglobulin E - immunology ; Immunopathology ; Infant, Newborn ; Intercellular Adhesion Molecule-1 - blood ; Interferon-gamma - blood ; Interleukin-5 - immunology ; Lipopolysaccharide Receptors - immunology ; Medical sciences ; Respiratory Sounds ; Respiratory syncytial virus ; Respiratory Syncytial Virus Infections - immunology ; Respiratory Syncytial Viruses ; skin prick test ; Skin Tests ; soluble ICAM-1</subject><ispartof>Clinical and experimental allergy, 2005-01, Vol.35 (1), p.59-63</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4665-3447e6ec15ad1c56ef90f88c5f2d208cb0ff94c2e8fdeeea092ab84252f84d1d3</citedby><cites>FETCH-LOGICAL-c4665-3447e6ec15ad1c56ef90f88c5f2d208cb0ff94c2e8fdeeea092ab84252f84d1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2222.2004.02125.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2222.2004.02125.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,4021,27921,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16468192$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15649267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Juntti, H.</creatorcontrib><creatorcontrib>Kokkonen, J.</creatorcontrib><creatorcontrib>Dunder, T.</creatorcontrib><creatorcontrib>Renko, M.</creatorcontrib><creatorcontrib>Karttunen, R.</creatorcontrib><creatorcontrib>Uhari, M.</creatorcontrib><title>Serum concentrations of interferon-γ and intercellular adhesion molecule-1 eight years after an early respiratory syncytial virus infection</title><title>Clinical and experimental allergy</title><addtitle>Clin Exp Allergy</addtitle><description>Summary
Background
Respiratory syncytial virus (RSV) infection may influence the development of recurrent wheezing and atopy, but the mechanisms are unclear.
Objective
The purpose was to evaluate serum concentrations of soluble intercellular adhesion molecule‐1 (sICAM‐1), CD14, IgE, IL‐5 and IFN‐γ in children 6–10 years after an RSV infection and their correlation with subsequent asthma and atopy.
Methods
Fifty‐one subjects admitted to hospital for RSV infection during the first year of life and controls matched for birth date and sex underwent clinical examinations including lung function, skin prick and blood tests.
Results
The RSV subjects had significantly higher serum concentrations of IFN‐γ and sICAM‐1 than the controls (for IFN‐γ 224.9 pg/mL (standard deviation (SD) 271.3) vs. 187.1 pg/mL (372.9), difference 37.8 pg/mL, 95% confidence interval (CI) −90.3 to 166.0, P=0.05; for sICAM‐1 170.2 ng/mL (SD 63) vs. 147.8 ng/mL (SD 57), difference 22.4 ng/mL, 95% CI −1.4 to 46.1, P=0.04). The RSV subjects with asthma had significantly higher concentrations of IFN‐γ than the controls with asthma, and the RSV subjects with wheezing during the previous 12 months had significantly higher concentrations of both IFN‐γ and sICAM‐1 than the controls with wheezing.
Conclusions
Children hospitalized for RSV infection in infancy still differ in IFN‐γ and sICAM‐1 production 6–10 years after the infection. The data suggest that the pathomechanism of asthma and wheezing after an early RSV infection may be different from that of children without an early RSV infection.</description><subject>Allergic diseases</subject><subject>Asthma - immunology</subject><subject>atopy</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Chi-Square Distribution</subject><subject>Child</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>IFN-γ</subject><subject>Immunoglobulin E - immunology</subject><subject>Immunopathology</subject><subject>Infant, Newborn</subject><subject>Intercellular Adhesion Molecule-1 - blood</subject><subject>Interferon-gamma - blood</subject><subject>Interleukin-5 - immunology</subject><subject>Lipopolysaccharide Receptors - immunology</subject><subject>Medical sciences</subject><subject>Respiratory Sounds</subject><subject>Respiratory syncytial virus</subject><subject>Respiratory Syncytial Virus Infections - immunology</subject><subject>Respiratory Syncytial Viruses</subject><subject>skin prick test</subject><subject>Skin Tests</subject><subject>soluble ICAM-1</subject><issn>0954-7894</issn><issn>1365-2222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU2O1DAQhS0EYpqBKyBvYJdgO7bjLFiMWkODNAIhBiGxsdxOmXHjTho7gc4duA334Ew4pDWzhNr473tVrnoIYUpKmuPFrqSVFAXLUTJCeEkYZaI83kOr24f7aEUawYtaNfwMPUppRwipRKMeojMqJG-YrFfo5weI4x7bvrPQDdEMvu8S7h323QDRQey74vcvbLp2ubEQwhhMxKa9gZRhvO8D2DFAQTH4LzcDnsDEhI3LdNbhfAoTjpAOPqfv44TT1Nlp8Cbg7z6OKSd2YOfCj9EDZ0KCJ6f1HH18dXm9fl1cvdu8WV9cFZbL3F3FeQ0SLBWmpVZIcA1xSlnhWMuIslviXMMtA-VaADCkYWarOBPMKd7StjpHz5e8h9h_GyENeu_T3JnpoB-TlnUl8xzlP0FaKykJIxlUC2hjn1IEpw_R702cNCV6tkzv9OyMnp3Rs2X6r2X6mKVPTzXG7R7aO-HJoww8OwEmWRNcNJ316Y6TXCrasMy9XLgfPsD03x_Q68uLeZf1xaL3aYDjrd7Er_NAaqE_vd1ovq7e19f8s95UfwCMbMV1</recordid><startdate>200501</startdate><enddate>200501</enddate><creator>Juntti, H.</creator><creator>Kokkonen, J.</creator><creator>Dunder, T.</creator><creator>Renko, M.</creator><creator>Karttunen, R.</creator><creator>Uhari, M.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200501</creationdate><title>Serum concentrations of interferon-γ and intercellular adhesion molecule-1 eight years after an early respiratory syncytial virus infection</title><author>Juntti, H. ; Kokkonen, J. ; Dunder, T. ; Renko, M. ; Karttunen, R. ; Uhari, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4665-3447e6ec15ad1c56ef90f88c5f2d208cb0ff94c2e8fdeeea092ab84252f84d1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Allergic diseases</topic><topic>Asthma - immunology</topic><topic>atopy</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Chi-Square Distribution</topic><topic>Child</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>IFN-γ</topic><topic>Immunoglobulin E - immunology</topic><topic>Immunopathology</topic><topic>Infant, Newborn</topic><topic>Intercellular Adhesion Molecule-1 - blood</topic><topic>Interferon-gamma - blood</topic><topic>Interleukin-5 - immunology</topic><topic>Lipopolysaccharide Receptors - immunology</topic><topic>Medical sciences</topic><topic>Respiratory Sounds</topic><topic>Respiratory syncytial virus</topic><topic>Respiratory Syncytial Virus Infections - immunology</topic><topic>Respiratory Syncytial Viruses</topic><topic>skin prick test</topic><topic>Skin Tests</topic><topic>soluble ICAM-1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Juntti, H.</creatorcontrib><creatorcontrib>Kokkonen, J.</creatorcontrib><creatorcontrib>Dunder, T.</creatorcontrib><creatorcontrib>Renko, M.</creatorcontrib><creatorcontrib>Karttunen, R.</creatorcontrib><creatorcontrib>Uhari, M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Juntti, H.</au><au>Kokkonen, J.</au><au>Dunder, T.</au><au>Renko, M.</au><au>Karttunen, R.</au><au>Uhari, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum concentrations of interferon-γ and intercellular adhesion molecule-1 eight years after an early respiratory syncytial virus infection</atitle><jtitle>Clinical and experimental allergy</jtitle><addtitle>Clin Exp Allergy</addtitle><date>2005-01</date><risdate>2005</risdate><volume>35</volume><issue>1</issue><spage>59</spage><epage>63</epage><pages>59-63</pages><issn>0954-7894</issn><eissn>1365-2222</eissn><abstract>Summary
Background
Respiratory syncytial virus (RSV) infection may influence the development of recurrent wheezing and atopy, but the mechanisms are unclear.
Objective
The purpose was to evaluate serum concentrations of soluble intercellular adhesion molecule‐1 (sICAM‐1), CD14, IgE, IL‐5 and IFN‐γ in children 6–10 years after an RSV infection and their correlation with subsequent asthma and atopy.
Methods
Fifty‐one subjects admitted to hospital for RSV infection during the first year of life and controls matched for birth date and sex underwent clinical examinations including lung function, skin prick and blood tests.
Results
The RSV subjects had significantly higher serum concentrations of IFN‐γ and sICAM‐1 than the controls (for IFN‐γ 224.9 pg/mL (standard deviation (SD) 271.3) vs. 187.1 pg/mL (372.9), difference 37.8 pg/mL, 95% confidence interval (CI) −90.3 to 166.0, P=0.05; for sICAM‐1 170.2 ng/mL (SD 63) vs. 147.8 ng/mL (SD 57), difference 22.4 ng/mL, 95% CI −1.4 to 46.1, P=0.04). The RSV subjects with asthma had significantly higher concentrations of IFN‐γ than the controls with asthma, and the RSV subjects with wheezing during the previous 12 months had significantly higher concentrations of both IFN‐γ and sICAM‐1 than the controls with wheezing.
Conclusions
Children hospitalized for RSV infection in infancy still differ in IFN‐γ and sICAM‐1 production 6–10 years after the infection. The data suggest that the pathomechanism of asthma and wheezing after an early RSV infection may be different from that of children without an early RSV infection.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15649267</pmid><doi>10.1111/j.1365-2222.2004.02125.x</doi><tpages>5</tpages></addata></record> |
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| ispartof | Clinical and experimental allergy, 2005-01, Vol.35 (1), p.59-63 |
| issn | 0954-7894 1365-2222 |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Allergic diseases Asthma - immunology atopy Biological and medical sciences Case-Control Studies Chi-Square Distribution Child Fundamental and applied biological sciences. Psychology Fundamental immunology Humans IFN-γ Immunoglobulin E - immunology Immunopathology Infant, Newborn Intercellular Adhesion Molecule-1 - blood Interferon-gamma - blood Interleukin-5 - immunology Lipopolysaccharide Receptors - immunology Medical sciences Respiratory Sounds Respiratory syncytial virus Respiratory Syncytial Virus Infections - immunology Respiratory Syncytial Viruses skin prick test Skin Tests soluble ICAM-1 |
| title | Serum concentrations of interferon-γ and intercellular adhesion molecule-1 eight years after an early respiratory syncytial virus infection |
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