Somatostatin Receptor 1 Selective Analogues: 3. Dicyclic Peptides

The binding affinity of short chain somatostatin (SRIF) analogues at the five human SRIF receptors (sst) was determined to identify sterically constrained somatostatin receptor subtype 1 (sst1) selective scaffolds. Des-AA ,,, -[d-Trp8]SRIF (2) retained high binding affinity at all receptors but sst1...

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Veröffentlicht in:	Journal of medicinal chemistry 2005-01, Vol.48 (2), p.515-522
Hauptverfasser:	Rivier, Jean E, Kirby, Dean A, Erchegyi, Judit, Waser, Beatrice, Eltschinger, Véronique, Cescato, Renzo, Reubi, Jean Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CHO Cells Colforsin - pharmacology Cricetinae Cricetulus Cyclic AMP - antagonists & inhibitors Cyclic AMP - biosynthesis Humans Peptides, Cyclic - chemical synthesis Peptides, Cyclic - chemistry Peptides, Cyclic - pharmacology Radioligand Assay Receptors, Somatostatin - agonists Somatostatin - analogs & derivatives Somatostatin - chemical synthesis Somatostatin - chemistry Somatostatin - pharmacology Structure-Activity Relationship
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