Caged Phosphoproteins

We present the chemical and biological synthesis of caged phosphoproteins using the in vitro nonsense codon suppression methodology. Specifically, phosphoamino acid analogues of serine, threonine, and tyrosine with a single photocleavable o-nitrophenylethyl caging group were synthesized as the amino...

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Veröffentlicht in:	Journal of the American Chemical Society 2005-01, Vol.127 (3), p.846-847
Hauptverfasser:	Rothman, Deborah M, Petersson, E. James, Vázquez, M. Eugenio, Brandt, Gabriel S, Dougherty, Dennis A, Imperiali, Barbara
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Chemistry Cyclic AMP-Dependent Protein Kinases - chemistry Cyclic AMP-Dependent Protein Kinases - metabolism Exact sciences and technology Fundamental and applied biological sciences. Psychology General aspects, investigation methods Organic chemistry Peptides Phosphoproteins - biosynthesis Phosphoproteins - chemical synthesis Phosphoproteins - chemistry Preparations and properties Proteins RNA, Transfer, Amino Acid-Specific - chemistry RNA, Transfer, Amino Acid-Specific - metabolism Serine - analogs & derivatives Serine - metabolism Threonine - analogs & derivatives Threonine - metabolism
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