Dissecting Contributions to the Denaturant Sensitivities of Proteins

Understanding the molecular basis for protein denaturation by urea and guanidinium chloride (GdmCl) should accommodate the observation that, on a molar basis, GdmCl is generally 2−2.5-fold more effective as a protein denaturant than urea. Previous studies [Smith, J. S., and Scholtz, J. M. (1996) Bio...

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Veröffentlicht in:	Biochemistry (Easton) 2005-01, Vol.44 (2), p.775-781
Hauptverfasser:	Dempsey, Christopher E, Piggot, Thomas J, Mason, Philip E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Circular Dichroism Guanidine - chemistry Molecular Sequence Data Peptides - chemistry Peptides - metabolism Protein Denaturation Protein Folding Protein Structure, Secondary Solutions Thermodynamics Tryptophan - chemistry Urea - chemistry
Online-Zugang:	Volltext
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