The impact of intravenous corticosteroids with third molar surgery in patients at high risk for delayed health-related quality of life and clinical recovery
To compare recovery for clinical and health-related quality of life (HRQOL) outcomes after third molar surgery in patients predicted to be at risk for delayed recovery, treated with or without intravenous (IV) corticosteroids at surgery. Patients at least 18 years of age and with all 4 third molars...
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| Veröffentlicht in: | Journal of oral and maxillofacial surgery 2005, Vol.63 (1), p.55-62 |
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| container_title | Journal of oral and maxillofacial surgery |
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| creator | Tiwana, Paul S. Foy, Susan P. Shugars, Daniel A. Marciani, Robert D. Conrad, Shawn M. Phillips, Ceib White, Raymond P. |
| description | To compare recovery for clinical and health-related quality of life (HRQOL) outcomes after third molar surgery in patients predicted to be at risk for delayed recovery, treated with or without intravenous (IV) corticosteroids at surgery.
Patients at least 18 years of age and with all 4 third molars below the occlusal plane were given IV corticosteroids just before third molar surgery. Clinical and HRQOL outcomes of these patients were compared with those of a nonconcurrent control group who did not receive corticosteroids. No antibiotics were administered. The control group was selected using the same criteria and treated under the same surgical protocol as the corticosteroid group. Differences between the groups were assessed with Cochran-Mantel-Haenszel row mean score statistics.
Sixty patients were in each cohort. The incidence of delayed clinical recovery, a postsurgery visit with treatment, was higher in the control group compared with the corticosteroid group. In the corticosteroid group, 6 patients (10%) had 1 postsurgery visit with treatment. In the control group without corticosteroids, 17 patients (28%) had at least 1 postsurgery visit with treatment (P = .01). Compared with the control group, nausea tended to bother patients less on postsurgery day 1 (P = .07); sleep was improved on postsurgery days 1 through 4 (P < .05). Though not statistically significant, corticosteroids reduced the patients’ reported recovery by at least 1 day for pain, lifestyle, and oral function.
Administration of IV corticosteroids before third molar surgery without antibiotics does not hamper clinical recovery even when healthy adult patients are predicted to have delayed recovery. Overall, IV corticosteroid administration had a limited, but beneficial effect on HRQOL outcomes. |
| doi_str_mv | 10.1016/j.joms.2004.01.029 |
| format | Article |
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Patients at least 18 years of age and with all 4 third molars below the occlusal plane were given IV corticosteroids just before third molar surgery. Clinical and HRQOL outcomes of these patients were compared with those of a nonconcurrent control group who did not receive corticosteroids. No antibiotics were administered. The control group was selected using the same criteria and treated under the same surgical protocol as the corticosteroid group. Differences between the groups were assessed with Cochran-Mantel-Haenszel row mean score statistics.
Sixty patients were in each cohort. The incidence of delayed clinical recovery, a postsurgery visit with treatment, was higher in the control group compared with the corticosteroid group. In the corticosteroid group, 6 patients (10%) had 1 postsurgery visit with treatment. In the control group without corticosteroids, 17 patients (28%) had at least 1 postsurgery visit with treatment (P = .01). Compared with the control group, nausea tended to bother patients less on postsurgery day 1 (P = .07); sleep was improved on postsurgery days 1 through 4 (P < .05). Though not statistically significant, corticosteroids reduced the patients’ reported recovery by at least 1 day for pain, lifestyle, and oral function.
Administration of IV corticosteroids before third molar surgery without antibiotics does not hamper clinical recovery even when healthy adult patients are predicted to have delayed recovery. Overall, IV corticosteroid administration had a limited, but beneficial effect on HRQOL outcomes.</description><identifier>ISSN: 0278-2391</identifier><identifier>EISSN: 1531-5053</identifier><identifier>DOI: 10.1016/j.joms.2004.01.029</identifier><identifier>PMID: 15635558</identifier><identifier>CODEN: JOMSDA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adrenal Cortex Hormones - administration & dosage ; Adult ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Chi-Square Distribution ; Cohort Studies ; Dentistry ; Female ; Humans ; Injections, Intravenous ; Male ; Medical sciences ; Molar, Third - surgery ; Odds Ratio ; Otorhinolaryngology. Stomatology ; Pain, Postoperative - prevention & control ; Pharmacology. Drug treatments ; Postoperative Nausea and Vomiting - prevention & control ; Preoperative Care ; Prospective Studies ; Quality of Life ; Recovery of Function - drug effects ; Risk ; Tooth Extraction - methods ; Tooth Extraction - psychology</subject><ispartof>Journal of oral and maxillofacial surgery, 2005, Vol.63 (1), p.55-62</ispartof><rights>2005 American Association of Oral and Maxillofacial Surgeons</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-facb438c0fff05668e7f12f2439517c513fa8c4c5032340da92743f2b2c42b3d3</citedby><cites>FETCH-LOGICAL-c384t-facb438c0fff05668e7f12f2439517c513fa8c4c5032340da92743f2b2c42b3d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.joms.2004.01.029$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,4023,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16462261$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15635558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tiwana, Paul S.</creatorcontrib><creatorcontrib>Foy, Susan P.</creatorcontrib><creatorcontrib>Shugars, Daniel A.</creatorcontrib><creatorcontrib>Marciani, Robert D.</creatorcontrib><creatorcontrib>Conrad, Shawn M.</creatorcontrib><creatorcontrib>Phillips, Ceib</creatorcontrib><creatorcontrib>White, Raymond P.</creatorcontrib><title>The impact of intravenous corticosteroids with third molar surgery in patients at high risk for delayed health-related quality of life and clinical recovery</title><title>Journal of oral and maxillofacial surgery</title><addtitle>J Oral Maxillofac Surg</addtitle><description>To compare recovery for clinical and health-related quality of life (HRQOL) outcomes after third molar surgery in patients predicted to be at risk for delayed recovery, treated with or without intravenous (IV) corticosteroids at surgery.
Patients at least 18 years of age and with all 4 third molars below the occlusal plane were given IV corticosteroids just before third molar surgery. Clinical and HRQOL outcomes of these patients were compared with those of a nonconcurrent control group who did not receive corticosteroids. No antibiotics were administered. The control group was selected using the same criteria and treated under the same surgical protocol as the corticosteroid group. Differences between the groups were assessed with Cochran-Mantel-Haenszel row mean score statistics.
Sixty patients were in each cohort. The incidence of delayed clinical recovery, a postsurgery visit with treatment, was higher in the control group compared with the corticosteroid group. In the corticosteroid group, 6 patients (10%) had 1 postsurgery visit with treatment. In the control group without corticosteroids, 17 patients (28%) had at least 1 postsurgery visit with treatment (P = .01). Compared with the control group, nausea tended to bother patients less on postsurgery day 1 (P = .07); sleep was improved on postsurgery days 1 through 4 (P < .05). Though not statistically significant, corticosteroids reduced the patients’ reported recovery by at least 1 day for pain, lifestyle, and oral function.
Administration of IV corticosteroids before third molar surgery without antibiotics does not hamper clinical recovery even when healthy adult patients are predicted to have delayed recovery. Overall, IV corticosteroid administration had a limited, but beneficial effect on HRQOL outcomes.</description><subject>Adrenal Cortex Hormones - administration & dosage</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Chi-Square Distribution</subject><subject>Cohort Studies</subject><subject>Dentistry</subject><subject>Female</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molar, Third - surgery</subject><subject>Odds Ratio</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Pain, Postoperative - prevention & control</subject><subject>Pharmacology. Drug treatments</subject><subject>Postoperative Nausea and Vomiting - prevention & control</subject><subject>Preoperative Care</subject><subject>Prospective Studies</subject><subject>Quality of Life</subject><subject>Recovery of Function - drug effects</subject><subject>Risk</subject><subject>Tooth Extraction - methods</subject><subject>Tooth Extraction - psychology</subject><issn>0278-2391</issn><issn>1531-5053</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS0EokPhBVggb2CX4J_YSSQ2qAKKVIlNWVse-7rx4MRT2xk078LD4tGM1F1X1pW-c67vOQi9p6SlhMrPu3YX59wyQrqW0Jaw8QXaUMFpI4jgL9GGsH5oGB_pFXqT844QSkUvX6MrKiQXQgwb9O9-AuznvTYFR4f9UpI-wBLXjE1MxZuYC6TobcZ_fZlwmXyyeI5BJ5zX9ADpWEV4r4uHpWSsC578w4STz3-wiwlbCPoIFk-gQ5maVMdSx8dVB1-Op53BO8B6sdgEv3ijA05g4qE6v0WvnA4Z3l3ea_T7-7f7m9vm7tePnzdf7xrDh640TpttxwdDnHNESDlA7yhzrOOjoL0RlDs9mM4IwhnviNUj6zvu2JaZjm255dfo09l3n-LjCrmo2WcDIegFahJK9lz0fT9WkJ1Bk2LOCZzaJz_rdFSUqFMnaqdOnahTJ4pQVTupog8X93U7g32SXEqowMcLoHM93yW9GJ-fONlJxiSt3JczBzWLg4eksqmpG7C-JlaUjf65f_wHFtauCQ</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Tiwana, Paul S.</creator><creator>Foy, Susan P.</creator><creator>Shugars, Daniel A.</creator><creator>Marciani, Robert D.</creator><creator>Conrad, Shawn M.</creator><creator>Phillips, Ceib</creator><creator>White, Raymond P.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>2005</creationdate><title>The impact of intravenous corticosteroids with third molar surgery in patients at high risk for delayed health-related quality of life and clinical recovery</title><author>Tiwana, Paul S. ; Foy, Susan P. ; Shugars, Daniel A. ; Marciani, Robert D. ; Conrad, Shawn M. ; Phillips, Ceib ; White, Raymond P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-facb438c0fff05668e7f12f2439517c513fa8c4c5032340da92743f2b2c42b3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adrenal Cortex Hormones - administration & dosage</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Chi-Square Distribution</topic><topic>Cohort Studies</topic><topic>Dentistry</topic><topic>Female</topic><topic>Humans</topic><topic>Injections, Intravenous</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molar, Third - surgery</topic><topic>Odds Ratio</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Pain, Postoperative - prevention & control</topic><topic>Pharmacology. Drug treatments</topic><topic>Postoperative Nausea and Vomiting - prevention & control</topic><topic>Preoperative Care</topic><topic>Prospective Studies</topic><topic>Quality of Life</topic><topic>Recovery of Function - drug effects</topic><topic>Risk</topic><topic>Tooth Extraction - methods</topic><topic>Tooth Extraction - psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tiwana, Paul S.</creatorcontrib><creatorcontrib>Foy, Susan P.</creatorcontrib><creatorcontrib>Shugars, Daniel A.</creatorcontrib><creatorcontrib>Marciani, Robert D.</creatorcontrib><creatorcontrib>Conrad, Shawn M.</creatorcontrib><creatorcontrib>Phillips, Ceib</creatorcontrib><creatorcontrib>White, Raymond P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Journal of oral and maxillofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tiwana, Paul S.</au><au>Foy, Susan P.</au><au>Shugars, Daniel A.</au><au>Marciani, Robert D.</au><au>Conrad, Shawn M.</au><au>Phillips, Ceib</au><au>White, Raymond P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of intravenous corticosteroids with third molar surgery in patients at high risk for delayed health-related quality of life and clinical recovery</atitle><jtitle>Journal of oral and maxillofacial surgery</jtitle><addtitle>J Oral Maxillofac Surg</addtitle><date>2005</date><risdate>2005</risdate><volume>63</volume><issue>1</issue><spage>55</spage><epage>62</epage><pages>55-62</pages><issn>0278-2391</issn><eissn>1531-5053</eissn><coden>JOMSDA</coden><abstract>To compare recovery for clinical and health-related quality of life (HRQOL) outcomes after third molar surgery in patients predicted to be at risk for delayed recovery, treated with or without intravenous (IV) corticosteroids at surgery.
Patients at least 18 years of age and with all 4 third molars below the occlusal plane were given IV corticosteroids just before third molar surgery. Clinical and HRQOL outcomes of these patients were compared with those of a nonconcurrent control group who did not receive corticosteroids. No antibiotics were administered. The control group was selected using the same criteria and treated under the same surgical protocol as the corticosteroid group. Differences between the groups were assessed with Cochran-Mantel-Haenszel row mean score statistics.
Sixty patients were in each cohort. The incidence of delayed clinical recovery, a postsurgery visit with treatment, was higher in the control group compared with the corticosteroid group. In the corticosteroid group, 6 patients (10%) had 1 postsurgery visit with treatment. In the control group without corticosteroids, 17 patients (28%) had at least 1 postsurgery visit with treatment (P = .01). Compared with the control group, nausea tended to bother patients less on postsurgery day 1 (P = .07); sleep was improved on postsurgery days 1 through 4 (P < .05). Though not statistically significant, corticosteroids reduced the patients’ reported recovery by at least 1 day for pain, lifestyle, and oral function.
Administration of IV corticosteroids before third molar surgery without antibiotics does not hamper clinical recovery even when healthy adult patients are predicted to have delayed recovery. Overall, IV corticosteroid administration had a limited, but beneficial effect on HRQOL outcomes.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15635558</pmid><doi>10.1016/j.joms.2004.01.029</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of oral and maxillofacial surgery, 2005, Vol.63 (1), p.55-62 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adrenal Cortex Hormones - administration & dosage Adult Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Chi-Square Distribution Cohort Studies Dentistry Female Humans Injections, Intravenous Male Medical sciences Molar, Third - surgery Odds Ratio Otorhinolaryngology. Stomatology Pain, Postoperative - prevention & control Pharmacology. Drug treatments Postoperative Nausea and Vomiting - prevention & control Preoperative Care Prospective Studies Quality of Life Recovery of Function - drug effects Risk Tooth Extraction - methods Tooth Extraction - psychology |
| title | The impact of intravenous corticosteroids with third molar surgery in patients at high risk for delayed health-related quality of life and clinical recovery |
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