Direct stimulation of optic nerve by electrodes implanted in optic disc of rabbit eyes
To determine whether wire microelectrodes implanted in the optic disc can be used to elicit cortical potentials. Two or four platinum wire electrodes of two types, viz., the cut-end type and the exposed-tip type, were inserted through the vitreous and fixed in the optic disc of 16 rabbit eyes. Elect...
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| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 2005-01, Vol.243 (1), p.49-56 |
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| creator | Fang, Xiaoyun Sakaguchi, Hirokazu Fujikado, Takashi Osanai, Makoto Kanda, Hiroyuki Ikuno, Yasushi Kamei, Motohiro Ohji, Masahito Gan, Dekang Choi, Junsub Yagi, Tetsuya Tano, Yasuo |
| description | To determine whether wire microelectrodes implanted in the optic disc can be used to elicit cortical potentials.
Two or four platinum wire electrodes of two types, viz., the cut-end type and the exposed-tip type, were inserted through the vitreous and fixed in the optic disc of 16 rabbit eyes. Electrically evoked potentials (EEPs) were recorded after bipolar electrical stimulation with the two wire electrodes and by different combinations of the four-electrode system. The optic discs were examined histologically after the experiment.
The wire electrodes were successfully implanted and fixed into different positions of the optic disc without serious complications in all 16 eyes. EEPs could be elicited after bipolar electrical stimulation of the optic nerve using either the two-electrode system or different pairs of the four-electrode system. Threshold charge densities to elicit EEPs were 0.32-0.64 mC/cm(2) in eyes using the cut-end type of electrodes and 0.93-6.21 muC/cm(2) in eyes using the exposed-tip type. The amplitude of the EEPs increased with increasing electrical stimulus intensities. Histological evaluation revealed limited damage to the neural tissue adjacent to the electrode track.
The visual cortex can be activated by direct microelectrical stimulation of the optic nerve. The acute implantation of the wire microelectrodes into the optic disc by a transvitreal approach is feasible and results in only limited damage to the optic nerve. |
| doi_str_mv | 10.1007/s00417-004-0957-0 |
| format | Article |
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Two or four platinum wire electrodes of two types, viz., the cut-end type and the exposed-tip type, were inserted through the vitreous and fixed in the optic disc of 16 rabbit eyes. Electrically evoked potentials (EEPs) were recorded after bipolar electrical stimulation with the two wire electrodes and by different combinations of the four-electrode system. The optic discs were examined histologically after the experiment.
The wire electrodes were successfully implanted and fixed into different positions of the optic disc without serious complications in all 16 eyes. EEPs could be elicited after bipolar electrical stimulation of the optic nerve using either the two-electrode system or different pairs of the four-electrode system. Threshold charge densities to elicit EEPs were 0.32-0.64 mC/cm(2) in eyes using the cut-end type of electrodes and 0.93-6.21 muC/cm(2) in eyes using the exposed-tip type. The amplitude of the EEPs increased with increasing electrical stimulus intensities. Histological evaluation revealed limited damage to the neural tissue adjacent to the electrode track.
The visual cortex can be activated by direct microelectrical stimulation of the optic nerve. The acute implantation of the wire microelectrodes into the optic disc by a transvitreal approach is feasible and results in only limited damage to the optic nerve.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-004-0957-0</identifier><identifier>PMID: 15378382</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Animals ; Electric Stimulation - methods ; Electrodes, Implanted ; Evoked Potentials, Visual - physiology ; Ophthalmology ; Optic Disk - physiology ; Optic Nerve - physiology ; Rabbits ; Visual Cortex - physiology</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2005-01, Vol.243 (1), p.49-56</ispartof><rights>Springer-Verlag 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-4b52555e2836c1ab66ba6ab21547eb3a895bff85a5e368983284f36848ccd2823</citedby><cites>FETCH-LOGICAL-c326t-4b52555e2836c1ab66ba6ab21547eb3a895bff85a5e368983284f36848ccd2823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15378382$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fang, Xiaoyun</creatorcontrib><creatorcontrib>Sakaguchi, Hirokazu</creatorcontrib><creatorcontrib>Fujikado, Takashi</creatorcontrib><creatorcontrib>Osanai, Makoto</creatorcontrib><creatorcontrib>Kanda, Hiroyuki</creatorcontrib><creatorcontrib>Ikuno, Yasushi</creatorcontrib><creatorcontrib>Kamei, Motohiro</creatorcontrib><creatorcontrib>Ohji, Masahito</creatorcontrib><creatorcontrib>Gan, Dekang</creatorcontrib><creatorcontrib>Choi, Junsub</creatorcontrib><creatorcontrib>Yagi, Tetsuya</creatorcontrib><creatorcontrib>Tano, Yasuo</creatorcontrib><title>Direct stimulation of optic nerve by electrodes implanted in optic disc of rabbit eyes</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>To determine whether wire microelectrodes implanted in the optic disc can be used to elicit cortical potentials.
Two or four platinum wire electrodes of two types, viz., the cut-end type and the exposed-tip type, were inserted through the vitreous and fixed in the optic disc of 16 rabbit eyes. Electrically evoked potentials (EEPs) were recorded after bipolar electrical stimulation with the two wire electrodes and by different combinations of the four-electrode system. The optic discs were examined histologically after the experiment.
The wire electrodes were successfully implanted and fixed into different positions of the optic disc without serious complications in all 16 eyes. EEPs could be elicited after bipolar electrical stimulation of the optic nerve using either the two-electrode system or different pairs of the four-electrode system. Threshold charge densities to elicit EEPs were 0.32-0.64 mC/cm(2) in eyes using the cut-end type of electrodes and 0.93-6.21 muC/cm(2) in eyes using the exposed-tip type. The amplitude of the EEPs increased with increasing electrical stimulus intensities. Histological evaluation revealed limited damage to the neural tissue adjacent to the electrode track.
The visual cortex can be activated by direct microelectrical stimulation of the optic nerve. The acute implantation of the wire microelectrodes into the optic disc by a transvitreal approach is feasible and results in only limited damage to the optic nerve.</description><subject>Animals</subject><subject>Electric Stimulation - methods</subject><subject>Electrodes, Implanted</subject><subject>Evoked Potentials, Visual - physiology</subject><subject>Ophthalmology</subject><subject>Optic Disk - physiology</subject><subject>Optic Nerve - physiology</subject><subject>Rabbits</subject><subject>Visual Cortex - physiology</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkE1LxDAURYMozjj6A9xIcOGumo-mzSzFbxhwozK7kLSvkKFtapIK8-9NmYLg5uUtzn3cHIQuKbmlhJR3gZCcllmaGVmLtByhJc25yErCtsdoSUpGM8nZdoHOQtiRBHJBT9GCCl5KLtkSfT1aD1XEIdpubHW0rseuwW6ItsI9-B_AZo-hTYx3NQRsu6HVfYQa237GahuqKeS1MTZi2EM4RyeNbgNczO8KfT4_fTy8Zpv3l7eH-01WcVbELDeCCSGASV5UVJuiMLrQhlGRl2C4lmthmkYKLYAXcp2-IvMmbbmsqppJxlfo5nB38O57hBBVl8pAmyqCG4MqSi6KpCaB1__AnRt9n7opxomkTEiSIHqAKu9C8NCowdtO-72iRE3G1cG4SlNNxtWUuZoPj6aD-i8xK-a_ohd7Kw</recordid><startdate>200501</startdate><enddate>200501</enddate><creator>Fang, Xiaoyun</creator><creator>Sakaguchi, Hirokazu</creator><creator>Fujikado, Takashi</creator><creator>Osanai, Makoto</creator><creator>Kanda, Hiroyuki</creator><creator>Ikuno, Yasushi</creator><creator>Kamei, Motohiro</creator><creator>Ohji, Masahito</creator><creator>Gan, Dekang</creator><creator>Choi, Junsub</creator><creator>Yagi, Tetsuya</creator><creator>Tano, Yasuo</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200501</creationdate><title>Direct stimulation of optic nerve by electrodes implanted in optic disc of rabbit eyes</title><author>Fang, Xiaoyun ; Sakaguchi, Hirokazu ; Fujikado, Takashi ; Osanai, Makoto ; Kanda, Hiroyuki ; Ikuno, Yasushi ; Kamei, Motohiro ; Ohji, Masahito ; Gan, Dekang ; Choi, Junsub ; Yagi, Tetsuya ; Tano, Yasuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-4b52555e2836c1ab66ba6ab21547eb3a895bff85a5e368983284f36848ccd2823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Electric Stimulation - methods</topic><topic>Electrodes, Implanted</topic><topic>Evoked Potentials, Visual - physiology</topic><topic>Ophthalmology</topic><topic>Optic Disk - physiology</topic><topic>Optic Nerve - physiology</topic><topic>Rabbits</topic><topic>Visual Cortex - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fang, Xiaoyun</creatorcontrib><creatorcontrib>Sakaguchi, Hirokazu</creatorcontrib><creatorcontrib>Fujikado, Takashi</creatorcontrib><creatorcontrib>Osanai, Makoto</creatorcontrib><creatorcontrib>Kanda, Hiroyuki</creatorcontrib><creatorcontrib>Ikuno, Yasushi</creatorcontrib><creatorcontrib>Kamei, Motohiro</creatorcontrib><creatorcontrib>Ohji, Masahito</creatorcontrib><creatorcontrib>Gan, Dekang</creatorcontrib><creatorcontrib>Choi, Junsub</creatorcontrib><creatorcontrib>Yagi, Tetsuya</creatorcontrib><creatorcontrib>Tano, Yasuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fang, Xiaoyun</au><au>Sakaguchi, Hirokazu</au><au>Fujikado, Takashi</au><au>Osanai, Makoto</au><au>Kanda, Hiroyuki</au><au>Ikuno, Yasushi</au><au>Kamei, Motohiro</au><au>Ohji, Masahito</au><au>Gan, Dekang</au><au>Choi, Junsub</au><au>Yagi, Tetsuya</au><au>Tano, Yasuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Direct stimulation of optic nerve by electrodes implanted in optic disc of rabbit eyes</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2005-01</date><risdate>2005</risdate><volume>243</volume><issue>1</issue><spage>49</spage><epage>56</epage><pages>49-56</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>To determine whether wire microelectrodes implanted in the optic disc can be used to elicit cortical potentials.
Two or four platinum wire electrodes of two types, viz., the cut-end type and the exposed-tip type, were inserted through the vitreous and fixed in the optic disc of 16 rabbit eyes. Electrically evoked potentials (EEPs) were recorded after bipolar electrical stimulation with the two wire electrodes and by different combinations of the four-electrode system. The optic discs were examined histologically after the experiment.
The wire electrodes were successfully implanted and fixed into different positions of the optic disc without serious complications in all 16 eyes. EEPs could be elicited after bipolar electrical stimulation of the optic nerve using either the two-electrode system or different pairs of the four-electrode system. Threshold charge densities to elicit EEPs were 0.32-0.64 mC/cm(2) in eyes using the cut-end type of electrodes and 0.93-6.21 muC/cm(2) in eyes using the exposed-tip type. The amplitude of the EEPs increased with increasing electrical stimulus intensities. Histological evaluation revealed limited damage to the neural tissue adjacent to the electrode track.
The visual cortex can be activated by direct microelectrical stimulation of the optic nerve. The acute implantation of the wire microelectrodes into the optic disc by a transvitreal approach is feasible and results in only limited damage to the optic nerve.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>15378382</pmid><doi>10.1007/s00417-004-0957-0</doi><tpages>8</tpages></addata></record> |
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| issn | 0721-832X 1435-702X |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Electric Stimulation - methods Electrodes, Implanted Evoked Potentials, Visual - physiology Ophthalmology Optic Disk - physiology Optic Nerve - physiology Rabbits Visual Cortex - physiology |
| title | Direct stimulation of optic nerve by electrodes implanted in optic disc of rabbit eyes |
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