Von Willebrand factor accelerates platelet adhesion and thrombus formation on a collagen surface in platelet-reduced blood under flow conditions

Plasma von Willebrand factor (VWF) has been identified as an indispensable factor for platelet adhesion and thrombus formation on a collagen surface under flow conditions. VWF binds to collagen and then tethers platelets to the collagen surface through interaction with platelet glycoprotein Ib and a...

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Veröffentlicht in:	Blood 2005-02, Vol.105 (3), p.1078-1084
Hauptverfasser:	Tomokiyo, Kazuhiko, Kamikubo, Yuichi, Hanada, Takako, Araki, Tatsuya, Nakatomi, Yasushi, Ogata, Yoichi, Jung, Stephanie M., Nakagaki, Tomohiro, Moroi, Masaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticoagulants - pharmacology Blood Component Removal Blood Platelets - drug effects Blood Platelets - physiology Cell Adhesion - drug effects Cell Adhesion - physiology Collagen Factor VIII - pharmacology Humans Platelet Count Thrombosis - physiopathology von Willebrand Factor - pharmacology
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