The unique structure of A-tracts and intrinsic DNA bending

Short runs of adenines are a ubiquitous DNA element in regulatory regions of many organisms. When runs of 4–6 adenine base pairs (‘A-tracts’) are repeated with the helical periodicity, they give rise to global curvature of the DNA double helix, which can be macroscopically characterized by anomalous...

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Veröffentlicht in:	Quarterly reviews of biophysics 2009-02, Vol.42 (1), p.41-81
Hauptverfasser:	Haran, Tali E., Mohanty, Udayan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Cells - metabolism Deoxyribonucleic acid DNA DNA - chemistry DNA - genetics DNA - metabolism Humans Microsatellite Repeats - drug effects Molecular biology Molecular structure Molecules Nucleic Acid Conformation
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