Antithrombogenic and Antiplatelet Activities of Extract from Maackia amyrensis Wood
Antithrombogenic and antiplatelet effects of a new drug, containing isoflavonoids (extract from the wood of Maackia amyrensis, a Far Eastern plant), were studied. A course (200 mg/kg intragastrically during 14 days) of Maackia amyrensis extract prevented intravascular clotting, initiated by applicat...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2009-02, Vol.147 (2), p.204-207 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Plotnikova, A. M Shulgau, Z. T Plotnikova, T. M Aliev, O. I Kulesh, N. I Mischenko, N. P Fedoreyev, S. A |
| description | Antithrombogenic and antiplatelet effects of a new drug, containing isoflavonoids (extract from the wood of Maackia amyrensis, a Far Eastern plant), were studied. A course (200 mg/kg intragastrically during 14 days) of Maackia amyrensis extract prevented intravascular clotting, initiated by application of 10% iron chloride solution on the vessel. The drug increased antiaggregant activity of the vascular wall and potentiated endothelium-dependent vasodilatation in ovariectomied rats. The reference drug ethinylestradiol (25 μg/kg intragastrically during 14 days) potentiated the antiaggregant effect of the endothelium, but was inferior to Maackia amyrensis extract in the capacity to induce endothelium-dependent vasodilatation in ovariectomied rats. |
| doi_str_mv | 10.1007/s10517-009-0475-5 |
| format | Article |
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The reference drug ethinylestradiol (25 μg/kg intragastrically during 14 days) potentiated the antiaggregant effect of the endothelium, but was inferior to Maackia amyrensis extract in the capacity to induce endothelium-dependent vasodilatation in ovariectomied rats.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-009-0475-5</identifier><identifier>PMID: 19513422</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Blood Coagulation - drug effects ; Cell Biology ; Ethinyl Estradiol - pharmacology ; ethinylestradiol ; Female ; Fibrinolytic Agents - pharmacology ; Internal Medicine ; Isoflavones - pharmacology ; isoflavonoids ; Laboratory Medicine ; Maackia - chemistry ; Maackia amyrensis extract ; Ovariectomy ; Pathology ; Pharmacology and Toxicology ; Plant Extracts - pharmacology ; Platelet Aggregation Inhibitors - pharmacology ; Rats ; Rats, Wistar ; thrombosis ; Vasodilation - drug effects ; Vasodilator Agents - pharmacology</subject><ispartof>Bulletin of experimental biology and medicine, 2009-02, Vol.147 (2), p.204-207</ispartof><rights>Springer Science+Business Media, Inc. 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-310919a3ce04acd73fc227edf2a5b5349d8f4ab6f1534d875f546dee6c7bd9873</citedby><cites>FETCH-LOGICAL-c393t-310919a3ce04acd73fc227edf2a5b5349d8f4ab6f1534d875f546dee6c7bd9873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-009-0475-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-009-0475-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19513422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Plotnikova, A. 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The drug increased antiaggregant activity of the vascular wall and potentiated endothelium-dependent vasodilatation in ovariectomied rats. 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A course (200 mg/kg intragastrically during 14 days) of Maackia amyrensis extract prevented intravascular clotting, initiated by application of 10% iron chloride solution on the vessel. The drug increased antiaggregant activity of the vascular wall and potentiated endothelium-dependent vasodilatation in ovariectomied rats. The reference drug ethinylestradiol (25 μg/kg intragastrically during 14 days) potentiated the antiaggregant effect of the endothelium, but was inferior to Maackia amyrensis extract in the capacity to induce endothelium-dependent vasodilatation in ovariectomied rats.</abstract><cop>Boston</cop><pub>Boston : Springer US</pub><pmid>19513422</pmid><doi>10.1007/s10517-009-0475-5</doi><tpages>4</tpages></addata></record> |
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| ispartof | Bulletin of experimental biology and medicine, 2009-02, Vol.147 (2), p.204-207 |
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| subjects | Animals Biomedical and Life Sciences Biomedicine Blood Coagulation - drug effects Cell Biology Ethinyl Estradiol - pharmacology ethinylestradiol Female Fibrinolytic Agents - pharmacology Internal Medicine Isoflavones - pharmacology isoflavonoids Laboratory Medicine Maackia - chemistry Maackia amyrensis extract Ovariectomy Pathology Pharmacology and Toxicology Plant Extracts - pharmacology Platelet Aggregation Inhibitors - pharmacology Rats Rats, Wistar thrombosis Vasodilation - drug effects Vasodilator Agents - pharmacology |
| title | Antithrombogenic and Antiplatelet Activities of Extract from Maackia amyrensis Wood |
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