Efficacy of L-Ornithine L-Aspartate in Acute Liver Failure: A Double-Blind, Randomized, Placebo-Controlled Study

Background & Aims In acute liver failure (ALF), high blood ammonia levels have been documented that correlate with mortality and complications. L-ornithine L-aspartate (LOLA) reduces ammonia levels by increasing hepatic ammonia disposal and its peripheral metabolism. Present study evaluated effi...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2009-06, Vol.136 (7), p.2159-2168
Hauptverfasser:	Acharya, Subrat Kumar, Bhatia, Vikram, Sreenivas, Vishnubhatla, Khanal, Shankar, Panda, Subrat Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Dipeptides - administration & dosage Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Female Follow-Up Studies Gastroenterology and Hepatology Humans Hyperammonemia - diagnosis Hyperammonemia - drug therapy Kaplan-Meier Estimate Liver Failure, Acute - diagnosis Liver Failure, Acute - drug therapy Liver Failure, Acute - mortality Male Probability Prospective Studies Reference Values Risk Assessment Statistics, Nonparametric Survival Analysis Treatment Outcome
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