Oxidation-Sensitive Polymeric Nanoparticles

Oxidation-Sensitive Polymeric Nanoparticles

We have recently demonstrated the possible use of organic polysulfides for the design of oxidation-sensitive colloidal carriers in the form of polymeric vesicles, which are particularly suitable for the encapsulation of hydrosoluble drugs. In the present research we extend our efforts to carriers sp...

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Veröffentlicht in:Langmuir 2005-01, Vol.21 (1), p.411-417
Hauptverfasser: Rehor, Annemie, Hubbell, Jeffrey A, Tirelli, Nicola
Format: Artikel
Sprache:eng
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Chemistry
Colloidal state and disperse state
Exact sciences and technology
General and physical chemistry
Membranes
Physical and chemical studies. Granulometry. Electrokinetic phenomena
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creator Rehor, Annemie
Hubbell, Jeffrey A
Tirelli, Nicola
description We have recently demonstrated the possible use of organic polysulfides for the design of oxidation-sensitive colloidal carriers in the form of polymeric vesicles, which are particularly suitable for the encapsulation of hydrosoluble drugs. In the present research we extend our efforts to carriers specifically suitable for hydrophobic molecules. Exploiting the living emulsion polymerization of episulfides, we have produced new cross-linked polysulfide nanoparticles. Here we demonstrate how this process allows the production of stable nanoparticles with a good control over their size and functionality. The nanoparticles showed negligible cytotoxicity on a fibroblast model; furthermore, they exhibited sensitivity to oxidative conditions, which first produce swelling and then solubilize the material.
doi_str_mv 10.1021/la0478043
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subjects Chemistry
Colloidal state and disperse state
Exact sciences and technology
General and physical chemistry
Membranes
Physical and chemical studies. Granulometry. Electrokinetic phenomena
title Oxidation-Sensitive Polymeric Nanoparticles
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