Effect of Bcl-xL overexpression on apoptosis and autophagy in recombinant Chinese hamster ovary cells under nutrient-deprived condition

Upon nutrient deprivation during culture, recombinant Chinese hamster ovary (rCHO) cells are subjected to two types of programmed cell death (PCD), apoptosis and autophagy. To investigate the effect of Bcl‐xL overexpression on apoptosis and autophagy in rCHO cells, an erythropoietin (EPO)‐producing...

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Veröffentlicht in:	Biotechnology and bioengineering 2009-07, Vol.103 (4), p.757-766
Hauptverfasser:	Kim, Yeon-Gu, Kim, Jee Yon, Mohan, Chaya, Lee, Gyun Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Autophagy bcl-2-Associated X Protein - biosynthesis bcl-2-Associated X Protein - genetics Bcl-xL Biological and medical sciences Biotechnology Cell Culture Techniques CHO Cells Cricetinae Cricetulus Culture Media - chemistry Fundamental and applied biological sciences. Psychology Gene Expression Regulation inducible expression rCHO cells
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