RNA interference of VCP/p97 increases Mallory body formation

In the present report, valosin-containing protein (VCP) was present in Mallory bodies (MBs). To determine if VCP plays a role in MB formation, primary cultured hepatocytes from drug-primed mice that spontaneously form MBs in vitro were studied. The results were compared with control normal hepatocyt...

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Veröffentlicht in:	Experimental and molecular pathology 2005-02, Vol.78 (1), p.1-9
Hauptverfasser:	Nan, Li, Wu, Yong, Bardag-Gorce, Fawzia, Li, Jun, French, Barbara A., Wilson, La Toyia, Khanh Nguyen, Sheila, French, Samuel W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases Aggresome Animals Biological and medical sciences Blotting, Western Cell Cycle Proteins - antagonists & inhibitors Cell Cycle Proteins - physiology Cells, Cultured Chymases Cytokeratin Disease Models, Animal Green Fluorescent Proteins - metabolism Hepatocytes - metabolism Inclusion Bodies - genetics Inclusion Bodies - metabolism Investigative techniques, diagnostic techniques (general aspects) Liver Male Mallory body Medical sciences Mice Mice, Inbred C3H Oligonucleotides, Antisense - pharmacology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques RNA Interference RNA, Messenger - metabolism Serine Endopeptidases - metabolism Transfection Ubiquitin Ubiquitin-Protein Ligase Complexes - genetics Ubiquitin-Protein Ligase Complexes - metabolism Valosin Containing Protein VCP
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