Intestinal Barrier Function and Weight Gain in Malnourished Children Taking Glutamine Supplemented Enteral Formula
ABSTRACT Objective: We examined the effect of standard formula and glutamine or glycine supplemented enteral formula on intestinal permeability and weight gain in children with malnutrition. Methods: 80 children aged 2 to 60 months with a weight‐for‐age z‐score less than −2 were studied. From Decemb...
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| Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 2005-01, Vol.40 (1), p.28-35 |
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| creator | Lima, Aldo A. M. Brito, Lúcia F. B. Ribeiro, Hildênia B. Martins, Ma Ceci V. Lustosa, Amália P. Rocha, Edna M. Lima, Noélia L. Monte, Cristina M. G. Guerrant, Richard L. |
| description | ABSTRACT
Objective:
We examined the effect of standard formula and glutamine or glycine supplemented enteral formula on intestinal permeability and weight gain in children with malnutrition.
Methods:
80 children aged 2 to 60 months with a weight‐for‐age z‐score less than −2 were studied. From December 1996 to April 1999, 27 study patients received nonsupplemented formula. From June 2001 to June 2002 an additional 53 patients were randomly assigned to receive formula supplemented with glutamine or glycine (isosmolar concentrations) for 10 days. Lactulose/mannitol excretion ratio was used as a measure of intestinal permeability and was performed before and after 10 days of nutritional rehabilitation. Weight was measured before and after treatment.
Results:
Patients were similar on admission with regard to age, sex, nutritional status and lactulose/mannitol ratio. The lactulose/mannitol ratio significantly improved (decreased) in children receiving formula supplemented with glutamine for 10 days but not in those receiving glycine or nonsupplemented formula. Weight gain occurred during therapy in all groups and was not statistically different among groups.
Conclusion:
Formula supplemented with glutamine improves intestinal barrier function compared with nonsupplemented formula but does not augment weight gain. |
| doi_str_mv | 10.1002/j.1536-4801.2005.tb00922.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67349728</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67349728</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2976-4a8b6673efca81f8db4b2ccb288377ad6736036e9211425f32e3ea50d09c11423</originalsourceid><addsrcrecordid>eNqVkdtq3DAQhkVpabZpX6GIQnvn7UjysXfNkt0mpAdoSi-FLI9jbWR5I9kkefvKrEmuC0KCmX_-mflEyAcGawbAP-_XLBN5kpbA1hwgW481QMX5-uEFWT2lXpIV8KJIOGP5CXkTwh4AijSD1-SEZTnPUi5WxF-4EcNonLL0THlv0NPt5PRoBkeVa-hfNDfdSHfKOBrPd2XdMHkTOmzopjO28ejotbo17obu7DSq3jikv6fDwWKP0byh5_H20X87-H6y6i151Sob8N3ynpI_2_Przbfk6ufuYvP1KtG8KuIOqqzzvBDYalWytmzqtOZa17wsRVGoJqZyEDlWccGUZ63gKFBl0ECl54g4JZ-Ovgc_3E1xSdmboNFa5XCYgowGaVXwMgq_HIXaDyF4bOXBm175R8lAzsTlXs5Y5YxVzsTlQlw-xOL3S5ep7rF5Ll0QR8HHRaCCVrb1ymkTnnW5KLOqYFGXHnX3g428wq2d7tHLDpUdOxn_DjIWscztIQ4FyRzKY9lmKTMWH_9jcnn564c42wIvq0r8A0k5rwc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67349728</pqid></control><display><type>article</type><title>Intestinal Barrier Function and Weight Gain in Malnourished Children Taking Glutamine Supplemented Enteral Formula</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><source>Access via Wiley Online Library</source><creator>Lima, Aldo A. M. ; Brito, Lúcia F. B. ; Ribeiro, Hildênia B. ; Martins, Ma Ceci V. ; Lustosa, Amália P. ; Rocha, Edna M. ; Lima, Noélia L. ; Monte, Cristina M. G. ; Guerrant, Richard L.</creator><creatorcontrib>Lima, Aldo A. M. ; Brito, Lúcia F. B. ; Ribeiro, Hildênia B. ; Martins, Ma Ceci V. ; Lustosa, Amália P. ; Rocha, Edna M. ; Lima, Noélia L. ; Monte, Cristina M. G. ; Guerrant, Richard L.</creatorcontrib><description>ABSTRACT
Objective:
We examined the effect of standard formula and glutamine or glycine supplemented enteral formula on intestinal permeability and weight gain in children with malnutrition.
Methods:
80 children aged 2 to 60 months with a weight‐for‐age z‐score less than −2 were studied. From December 1996 to April 1999, 27 study patients received nonsupplemented formula. From June 2001 to June 2002 an additional 53 patients were randomly assigned to receive formula supplemented with glutamine or glycine (isosmolar concentrations) for 10 days. Lactulose/mannitol excretion ratio was used as a measure of intestinal permeability and was performed before and after 10 days of nutritional rehabilitation. Weight was measured before and after treatment.
Results:
Patients were similar on admission with regard to age, sex, nutritional status and lactulose/mannitol ratio. The lactulose/mannitol ratio significantly improved (decreased) in children receiving formula supplemented with glutamine for 10 days but not in those receiving glycine or nonsupplemented formula. Weight gain occurred during therapy in all groups and was not statistically different among groups.
Conclusion:
Formula supplemented with glutamine improves intestinal barrier function compared with nonsupplemented formula but does not augment weight gain.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1002/j.1536-4801.2005.tb00922.x</identifier><identifier>PMID: 15625423</identifier><identifier>CODEN: JPGND6</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Biological and medical sciences ; Child Nutrition Disorders - metabolism ; Child Nutrition Disorders - therapy ; Child, Preschool ; Enteral Nutrition ; Female ; Glutamine ; Glutamine - therapeutic use ; Glycine ; Glycine - therapeutic use ; Humans ; Infant ; Intestinal Absorption - drug effects ; Intestinal Absorption - physiology ; Intestinal Mucosa - drug effects ; Intestinal Mucosa - metabolism ; Intestinal permeability ; Lactulose - metabolism ; Male ; Malnutrition ; Mannitol - metabolism ; Medical sciences ; Metabolic diseases ; Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) ; Persistent diarrhea ; Weight Gain - drug effects</subject><ispartof>Journal of pediatric gastroenterology and nutrition, 2005-01, Vol.40 (1), p.28-35</ispartof><rights>2005 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition</rights><rights>2005 Lippincott Williams & Wilkins, Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2976-4a8b6673efca81f8db4b2ccb288377ad6736036e9211425f32e3ea50d09c11423</citedby><cites>FETCH-LOGICAL-c2976-4a8b6673efca81f8db4b2ccb288377ad6736036e9211425f32e3ea50d09c11423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fj.1536-4801.2005.tb00922.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fj.1536-4801.2005.tb00922.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,4028,27932,27933,27934,45583,45584</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16385971$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15625423$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lima, Aldo A. M.</creatorcontrib><creatorcontrib>Brito, Lúcia F. B.</creatorcontrib><creatorcontrib>Ribeiro, Hildênia B.</creatorcontrib><creatorcontrib>Martins, Ma Ceci V.</creatorcontrib><creatorcontrib>Lustosa, Amália P.</creatorcontrib><creatorcontrib>Rocha, Edna M.</creatorcontrib><creatorcontrib>Lima, Noélia L.</creatorcontrib><creatorcontrib>Monte, Cristina M. G.</creatorcontrib><creatorcontrib>Guerrant, Richard L.</creatorcontrib><title>Intestinal Barrier Function and Weight Gain in Malnourished Children Taking Glutamine Supplemented Enteral Formula</title><title>Journal of pediatric gastroenterology and nutrition</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>ABSTRACT
Objective:
We examined the effect of standard formula and glutamine or glycine supplemented enteral formula on intestinal permeability and weight gain in children with malnutrition.
Methods:
80 children aged 2 to 60 months with a weight‐for‐age z‐score less than −2 were studied. From December 1996 to April 1999, 27 study patients received nonsupplemented formula. From June 2001 to June 2002 an additional 53 patients were randomly assigned to receive formula supplemented with glutamine or glycine (isosmolar concentrations) for 10 days. Lactulose/mannitol excretion ratio was used as a measure of intestinal permeability and was performed before and after 10 days of nutritional rehabilitation. Weight was measured before and after treatment.
Results:
Patients were similar on admission with regard to age, sex, nutritional status and lactulose/mannitol ratio. The lactulose/mannitol ratio significantly improved (decreased) in children receiving formula supplemented with glutamine for 10 days but not in those receiving glycine or nonsupplemented formula. Weight gain occurred during therapy in all groups and was not statistically different among groups.
Conclusion:
Formula supplemented with glutamine improves intestinal barrier function compared with nonsupplemented formula but does not augment weight gain.</description><subject>Biological and medical sciences</subject><subject>Child Nutrition Disorders - metabolism</subject><subject>Child Nutrition Disorders - therapy</subject><subject>Child, Preschool</subject><subject>Enteral Nutrition</subject><subject>Female</subject><subject>Glutamine</subject><subject>Glutamine - therapeutic use</subject><subject>Glycine</subject><subject>Glycine - therapeutic use</subject><subject>Humans</subject><subject>Infant</subject><subject>Intestinal Absorption - drug effects</subject><subject>Intestinal Absorption - physiology</subject><subject>Intestinal Mucosa - drug effects</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestinal permeability</subject><subject>Lactulose - metabolism</subject><subject>Male</subject><subject>Malnutrition</subject><subject>Mannitol - metabolism</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</subject><subject>Persistent diarrhea</subject><subject>Weight Gain - drug effects</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkdtq3DAQhkVpabZpX6GIQnvn7UjysXfNkt0mpAdoSi-FLI9jbWR5I9kkefvKrEmuC0KCmX_-mflEyAcGawbAP-_XLBN5kpbA1hwgW481QMX5-uEFWT2lXpIV8KJIOGP5CXkTwh4AijSD1-SEZTnPUi5WxF-4EcNonLL0THlv0NPt5PRoBkeVa-hfNDfdSHfKOBrPd2XdMHkTOmzopjO28ejotbo17obu7DSq3jikv6fDwWKP0byh5_H20X87-H6y6i151Sob8N3ynpI_2_Przbfk6ufuYvP1KtG8KuIOqqzzvBDYalWytmzqtOZa17wsRVGoJqZyEDlWccGUZ63gKFBl0ECl54g4JZ-Ovgc_3E1xSdmboNFa5XCYgowGaVXwMgq_HIXaDyF4bOXBm175R8lAzsTlXs5Y5YxVzsTlQlw-xOL3S5ep7rF5Ll0QR8HHRaCCVrb1ymkTnnW5KLOqYFGXHnX3g428wq2d7tHLDpUdOxn_DjIWscztIQ4FyRzKY9lmKTMWH_9jcnn564c42wIvq0r8A0k5rwc</recordid><startdate>200501</startdate><enddate>200501</enddate><creator>Lima, Aldo A. M.</creator><creator>Brito, Lúcia F. B.</creator><creator>Ribeiro, Hildênia B.</creator><creator>Martins, Ma Ceci V.</creator><creator>Lustosa, Amália P.</creator><creator>Rocha, Edna M.</creator><creator>Lima, Noélia L.</creator><creator>Monte, Cristina M. G.</creator><creator>Guerrant, Richard L.</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200501</creationdate><title>Intestinal Barrier Function and Weight Gain in Malnourished Children Taking Glutamine Supplemented Enteral Formula</title><author>Lima, Aldo A. M. ; Brito, Lúcia F. B. ; Ribeiro, Hildênia B. ; Martins, Ma Ceci V. ; Lustosa, Amália P. ; Rocha, Edna M. ; Lima, Noélia L. ; Monte, Cristina M. G. ; Guerrant, Richard L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2976-4a8b6673efca81f8db4b2ccb288377ad6736036e9211425f32e3ea50d09c11423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biological and medical sciences</topic><topic>Child Nutrition Disorders - metabolism</topic><topic>Child Nutrition Disorders - therapy</topic><topic>Child, Preschool</topic><topic>Enteral Nutrition</topic><topic>Female</topic><topic>Glutamine</topic><topic>Glutamine - therapeutic use</topic><topic>Glycine</topic><topic>Glycine - therapeutic use</topic><topic>Humans</topic><topic>Infant</topic><topic>Intestinal Absorption - drug effects</topic><topic>Intestinal Absorption - physiology</topic><topic>Intestinal Mucosa - drug effects</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestinal permeability</topic><topic>Lactulose - metabolism</topic><topic>Male</topic><topic>Malnutrition</topic><topic>Mannitol - metabolism</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</topic><topic>Persistent diarrhea</topic><topic>Weight Gain - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lima, Aldo A. M.</creatorcontrib><creatorcontrib>Brito, Lúcia F. B.</creatorcontrib><creatorcontrib>Ribeiro, Hildênia B.</creatorcontrib><creatorcontrib>Martins, Ma Ceci V.</creatorcontrib><creatorcontrib>Lustosa, Amália P.</creatorcontrib><creatorcontrib>Rocha, Edna M.</creatorcontrib><creatorcontrib>Lima, Noélia L.</creatorcontrib><creatorcontrib>Monte, Cristina M. G.</creatorcontrib><creatorcontrib>Guerrant, Richard L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lima, Aldo A. M.</au><au>Brito, Lúcia F. B.</au><au>Ribeiro, Hildênia B.</au><au>Martins, Ma Ceci V.</au><au>Lustosa, Amália P.</au><au>Rocha, Edna M.</au><au>Lima, Noélia L.</au><au>Monte, Cristina M. G.</au><au>Guerrant, Richard L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intestinal Barrier Function and Weight Gain in Malnourished Children Taking Glutamine Supplemented Enteral Formula</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>2005-01</date><risdate>2005</risdate><volume>40</volume><issue>1</issue><spage>28</spage><epage>35</epage><pages>28-35</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><coden>JPGND6</coden><abstract>ABSTRACT
Objective:
We examined the effect of standard formula and glutamine or glycine supplemented enteral formula on intestinal permeability and weight gain in children with malnutrition.
Methods:
80 children aged 2 to 60 months with a weight‐for‐age z‐score less than −2 were studied. From December 1996 to April 1999, 27 study patients received nonsupplemented formula. From June 2001 to June 2002 an additional 53 patients were randomly assigned to receive formula supplemented with glutamine or glycine (isosmolar concentrations) for 10 days. Lactulose/mannitol excretion ratio was used as a measure of intestinal permeability and was performed before and after 10 days of nutritional rehabilitation. Weight was measured before and after treatment.
Results:
Patients were similar on admission with regard to age, sex, nutritional status and lactulose/mannitol ratio. The lactulose/mannitol ratio significantly improved (decreased) in children receiving formula supplemented with glutamine for 10 days but not in those receiving glycine or nonsupplemented formula. Weight gain occurred during therapy in all groups and was not statistically different among groups.
Conclusion:
Formula supplemented with glutamine improves intestinal barrier function compared with nonsupplemented formula but does not augment weight gain.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>15625423</pmid><doi>10.1002/j.1536-4801.2005.tb00922.x</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of pediatric gastroenterology and nutrition, 2005-01, Vol.40 (1), p.28-35 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete; Access via Wiley Online Library |
| subjects | Biological and medical sciences Child Nutrition Disorders - metabolism Child Nutrition Disorders - therapy Child, Preschool Enteral Nutrition Female Glutamine Glutamine - therapeutic use Glycine Glycine - therapeutic use Humans Infant Intestinal Absorption - drug effects Intestinal Absorption - physiology Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestinal permeability Lactulose - metabolism Male Malnutrition Mannitol - metabolism Medical sciences Metabolic diseases Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) Persistent diarrhea Weight Gain - drug effects |
| title | Intestinal Barrier Function and Weight Gain in Malnourished Children Taking Glutamine Supplemented Enteral Formula |
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