Bronchioloalveolar carcinoma: a new cancer in Peutz-Jeghers syndrome
Besides gastrointestinal hamartomatous polyposis and melanin spots in the skin and mucosa, patients with the Peutz-Jeghers syndrome (PJS) have repeatedly been observed with a variety of tumours, including lung cancer. Available data indicate an increased cancer risk among PJS patients, which suggest...
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| Veröffentlicht in: | Lung cancer (Amsterdam, Netherlands) Netherlands), 2005-02, Vol.47 (2), p.283-288 |
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| container_title | Lung cancer (Amsterdam, Netherlands) |
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| creator | von Herbay, A. Arens, N. Friedl, W. Vogt-Moykopf, I. Kayser, K. Müller, K.M. Back, W. |
| description | Besides gastrointestinal hamartomatous polyposis and melanin spots in the skin and mucosa, patients with the Peutz-Jeghers syndrome (PJS) have repeatedly been observed with a variety of tumours, including lung cancer. Available data indicate an increased cancer risk among PJS patients, which suggests that the gene involved in PJS,
STK11 on chromosome 19p13.3, may be a tumour suppressor gene. Herein, bronchioloalveolar carcinoma (BAC) of mucinous type is reported in a 22-year old male PJS patient with a novel germline frameshift insertion in exon 2 at codon 118 of the
STK11 gene. Molecular studies of his BAC indicated loss of heterozygosity (LOH) in the region of
STK11 on chromosome 19p13.3. This observation supports the hypothesis that
STK11 is a tumour suppressor gene which is involved in the development of lung adenocarcinoma. |
| doi_str_mv | 10.1016/j.lungcan.2004.06.015 |
| format | Article |
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STK11 on chromosome 19p13.3, may be a tumour suppressor gene. Herein, bronchioloalveolar carcinoma (BAC) of mucinous type is reported in a 22-year old male PJS patient with a novel germline frameshift insertion in exon 2 at codon 118 of the
STK11 gene. Molecular studies of his BAC indicated loss of heterozygosity (LOH) in the region of
STK11 on chromosome 19p13.3. This observation supports the hypothesis that
STK11 is a tumour suppressor gene which is involved in the development of lung adenocarcinoma.</description><identifier>ISSN: 0169-5002</identifier><identifier>EISSN: 1872-8332</identifier><identifier>DOI: 10.1016/j.lungcan.2004.06.015</identifier><identifier>PMID: 15639728</identifier><identifier>CODEN: LUCAE5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adenocarcinoma ; Adenocarcinoma, Bronchiolo-Alveolar - etiology ; Adenocarcinoma, Bronchiolo-Alveolar - genetics ; Adult ; Base Sequence ; Biological and medical sciences ; Bronchioloalveolar carcinoma ; Chromosomes, Human, Pair 19 ; Dermatology ; Genes, Tumor Suppressor ; Humans ; Loss of Heterozygosity ; Lung cancer ; Lung Neoplasms - etiology ; Lung Neoplasms - genetics ; Male ; Medical sciences ; Molecular Sequence Data ; Peutz-Jeghers syndrome ; Peutz-Jeghers Syndrome - complications ; Peutz-Jeghers Syndrome - genetics ; Pigmentary diseases of the skin ; Pneumology ; Polymerase Chain Reaction ; Protein-Serine-Threonine Kinases - genetics ; STK11/ LKB1 gene ; Tumors of the respiratory system and mediastinum</subject><ispartof>Lung cancer (Amsterdam, Netherlands), 2005-02, Vol.47 (2), p.283-288</ispartof><rights>2004 Elsevier Ireland Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-72a4c15c894322e61a320199e0cf7a8538e3766665f425d5379b2db7dc6ac18e3</citedby><cites>FETCH-LOGICAL-c393t-72a4c15c894322e61a320199e0cf7a8538e3766665f425d5379b2db7dc6ac18e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.lungcan.2004.06.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16407339$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15639728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>von Herbay, A.</creatorcontrib><creatorcontrib>Arens, N.</creatorcontrib><creatorcontrib>Friedl, W.</creatorcontrib><creatorcontrib>Vogt-Moykopf, I.</creatorcontrib><creatorcontrib>Kayser, K.</creatorcontrib><creatorcontrib>Müller, K.M.</creatorcontrib><creatorcontrib>Back, W.</creatorcontrib><title>Bronchioloalveolar carcinoma: a new cancer in Peutz-Jeghers syndrome</title><title>Lung cancer (Amsterdam, Netherlands)</title><addtitle>Lung Cancer</addtitle><description>Besides gastrointestinal hamartomatous polyposis and melanin spots in the skin and mucosa, patients with the Peutz-Jeghers syndrome (PJS) have repeatedly been observed with a variety of tumours, including lung cancer. Available data indicate an increased cancer risk among PJS patients, which suggests that the gene involved in PJS,
STK11 on chromosome 19p13.3, may be a tumour suppressor gene. Herein, bronchioloalveolar carcinoma (BAC) of mucinous type is reported in a 22-year old male PJS patient with a novel germline frameshift insertion in exon 2 at codon 118 of the
STK11 gene. Molecular studies of his BAC indicated loss of heterozygosity (LOH) in the region of
STK11 on chromosome 19p13.3. This observation supports the hypothesis that
STK11 is a tumour suppressor gene which is involved in the development of lung adenocarcinoma.</description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma, Bronchiolo-Alveolar - etiology</subject><subject>Adenocarcinoma, Bronchiolo-Alveolar - genetics</subject><subject>Adult</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Bronchioloalveolar carcinoma</subject><subject>Chromosomes, Human, Pair 19</subject><subject>Dermatology</subject><subject>Genes, Tumor Suppressor</subject><subject>Humans</subject><subject>Loss of Heterozygosity</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - etiology</subject><subject>Lung Neoplasms - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Peutz-Jeghers syndrome</subject><subject>Peutz-Jeghers Syndrome - complications</subject><subject>Peutz-Jeghers Syndrome - genetics</subject><subject>Pigmentary diseases of the skin</subject><subject>Pneumology</subject><subject>Polymerase Chain Reaction</subject><subject>Protein-Serine-Threonine Kinases - genetics</subject><subject>STK11/ LKB1 gene</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0169-5002</issn><issn>1872-8332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PGzEQQK2KqoS0P6HVXuC2W3-s7XUvqA20gCK1Bzhbjnc2ONq1g50FhV9fo6yUI3MZaebN2PMQ-kpwRTAR3zdVP_q1Nb6iGNcVFhUm_AOakUbSsmGMnqBZ5lTJMaan6CylDcZEEqw-oVPCBVOSNjN09SsGbx9d6IPpnyH0JhbWROt8GMyPwhQeXnLBW4iF88U_GHev5R2sHyGmIu19G8MAn9HHzvQJvkx5jh5-X98vbsrl3z-3i5_L0jLFdqWkpraE20bVjFIQxDCKiVKAbSdNw1kDTIocvKspbzmTakXblWytMJbk5hxdHPZuY3gaIe304JKFvjcewpi0kKxWhNAM8gNoY0gpQqe30Q0m7jXB-k2f3uhJn37Tp7HQWV-e-zY9MK4GaI9Tk68MnE-ASdb0XcxmXDpyosaS5WPn6PLAQdbx7CDqZB1ki62LYHe6De6dr_wHmhmPoQ</recordid><startdate>20050201</startdate><enddate>20050201</enddate><creator>von Herbay, A.</creator><creator>Arens, N.</creator><creator>Friedl, W.</creator><creator>Vogt-Moykopf, I.</creator><creator>Kayser, K.</creator><creator>Müller, K.M.</creator><creator>Back, W.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050201</creationdate><title>Bronchioloalveolar carcinoma: a new cancer in Peutz-Jeghers syndrome</title><author>von Herbay, A. ; Arens, N. ; Friedl, W. ; Vogt-Moykopf, I. ; Kayser, K. ; Müller, K.M. ; Back, W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-72a4c15c894322e61a320199e0cf7a8538e3766665f425d5379b2db7dc6ac18e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adenocarcinoma</topic><topic>Adenocarcinoma, Bronchiolo-Alveolar - etiology</topic><topic>Adenocarcinoma, Bronchiolo-Alveolar - genetics</topic><topic>Adult</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Bronchioloalveolar carcinoma</topic><topic>Chromosomes, Human, Pair 19</topic><topic>Dermatology</topic><topic>Genes, Tumor Suppressor</topic><topic>Humans</topic><topic>Loss of Heterozygosity</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - etiology</topic><topic>Lung Neoplasms - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Peutz-Jeghers syndrome</topic><topic>Peutz-Jeghers Syndrome - complications</topic><topic>Peutz-Jeghers Syndrome - genetics</topic><topic>Pigmentary diseases of the skin</topic><topic>Pneumology</topic><topic>Polymerase Chain Reaction</topic><topic>Protein-Serine-Threonine Kinases - genetics</topic><topic>STK11/ LKB1 gene</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>von Herbay, A.</creatorcontrib><creatorcontrib>Arens, N.</creatorcontrib><creatorcontrib>Friedl, W.</creatorcontrib><creatorcontrib>Vogt-Moykopf, I.</creatorcontrib><creatorcontrib>Kayser, K.</creatorcontrib><creatorcontrib>Müller, K.M.</creatorcontrib><creatorcontrib>Back, W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>von Herbay, A.</au><au>Arens, N.</au><au>Friedl, W.</au><au>Vogt-Moykopf, I.</au><au>Kayser, K.</au><au>Müller, K.M.</au><au>Back, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bronchioloalveolar carcinoma: a new cancer in Peutz-Jeghers syndrome</atitle><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle><addtitle>Lung Cancer</addtitle><date>2005-02-01</date><risdate>2005</risdate><volume>47</volume><issue>2</issue><spage>283</spage><epage>288</epage><pages>283-288</pages><issn>0169-5002</issn><eissn>1872-8332</eissn><coden>LUCAE5</coden><abstract>Besides gastrointestinal hamartomatous polyposis and melanin spots in the skin and mucosa, patients with the Peutz-Jeghers syndrome (PJS) have repeatedly been observed with a variety of tumours, including lung cancer. Available data indicate an increased cancer risk among PJS patients, which suggests that the gene involved in PJS,
STK11 on chromosome 19p13.3, may be a tumour suppressor gene. Herein, bronchioloalveolar carcinoma (BAC) of mucinous type is reported in a 22-year old male PJS patient with a novel germline frameshift insertion in exon 2 at codon 118 of the
STK11 gene. Molecular studies of his BAC indicated loss of heterozygosity (LOH) in the region of
STK11 on chromosome 19p13.3. This observation supports the hypothesis that
STK11 is a tumour suppressor gene which is involved in the development of lung adenocarcinoma.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>15639728</pmid><doi>10.1016/j.lungcan.2004.06.015</doi><tpages>6</tpages></addata></record> |
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| subjects | Adenocarcinoma Adenocarcinoma, Bronchiolo-Alveolar - etiology Adenocarcinoma, Bronchiolo-Alveolar - genetics Adult Base Sequence Biological and medical sciences Bronchioloalveolar carcinoma Chromosomes, Human, Pair 19 Dermatology Genes, Tumor Suppressor Humans Loss of Heterozygosity Lung cancer Lung Neoplasms - etiology Lung Neoplasms - genetics Male Medical sciences Molecular Sequence Data Peutz-Jeghers syndrome Peutz-Jeghers Syndrome - complications Peutz-Jeghers Syndrome - genetics Pigmentary diseases of the skin Pneumology Polymerase Chain Reaction Protein-Serine-Threonine Kinases - genetics STK11/ LKB1 gene Tumors of the respiratory system and mediastinum |
| title | Bronchioloalveolar carcinoma: a new cancer in Peutz-Jeghers syndrome |
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