CDK4 is a probable target gene in a novel amplicon at 12q13.3-q14.1 in lung cancer

Several chromosomal regions are recurrently amplified or deleted in lung tumors, but little is known about the underlying genes, which could be important mediators in tumor formation or progression. In lung cancer, the RB1–CCND1–CDKN2A pathway, involved in the G1–S transition, is damaged in nearly a...

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Veröffentlicht in:	Genes chromosomes & cancer 2005-02, Vol.42 (2), p.193-199
Hauptverfasser:	Wikman, Harriet, Nymark, Penny, Väyrynen, Aki, Jarmalaite, Sonata, Kallioniemi, Anne, Salmenkivi, Kaisa, Vainio-Siukola, Katri, Husgafvel-Pursiainen, Kirsti, Knuutila, Sakari, Wolf, Maija, Anttila, Sisko
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromosome Mapping - methods Chromosomes, Human, Pair 12 - genetics Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinases - genetics DNA, Neoplasm - genetics Gene Amplification - genetics Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic - genetics Humans Immunohistochemistry Lung Neoplasms - genetics Lung Neoplasms - pathology Microarray Analysis - methods Nucleic Acid Hybridization - methods Proto-Oncogene Proteins - genetics
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