RAMP2 and RAMP3 mRNA levels are increased in failing rat cardiomyocytes and associated with increased responsiveness to adrenomedullin
Adrenomedullin (AM) is a potent vasorelaxing peptide with natriuretic and diuretic actions. Recent data indicate that AM may function as an endogenous regulator of cardiac function. We investigated to what extent AM, the AM receptor subtypes, and AM receptor-associated proteins were regulated in car...
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| Veröffentlicht in: | Journal of molecular and cellular cardiology 2005, Vol.38 (1), p.145-151 |
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| creator | Øie, Erik Vinge, Leif Erik Andersen, Geir Øystein Yndestad, Arne Krobert, Kurt A. Sandberg, Cecilie Ahmed, Mohammed Shakil Haug, Terje Levy, Finn Olav Skomedal, Tor Attramadal, Håvard |
| description | Adrenomedullin (AM) is a potent vasorelaxing peptide with natriuretic and diuretic actions. Recent data indicate that AM may function as an endogenous regulator of cardiac function. We investigated to what extent AM, the AM receptor subtypes, and AM receptor-associated proteins were regulated in cardiomyocytes and non-cardiomyocytes of rats with congestive heart failure (CHF), and whether such regulation was paralleled by corresponding alterations of functional responses to AM. Cardiomyocytes and non-cardiomyocytes were isolated from myocardial tissue of rats 7 days after induction of myocardial infarction or sham operation. AM immunoreactivity was found in cardiomyocytes, endothelial cells, and fibroblasts. Robust increase of AM mRNA levels was observed both in the cardiomyocytes and in the non-cardiomyocytes of CHF rats compared to that of sham-operated rats (2.7-fold and 3.7-fold, respectively,
P < 0.05). Fairly high mRNA levels and immunoreactivity against the AM receptor chaperone receptor activity-modifying protein-2 (RAMP2) were also detected in the cardiomyocytes and non-cardiomyocytes. However, induction of RAMP2 mRNA expression was restricted to cardiomyocytes (1.8-fold increase in cardiomyocytes from CHF rats vs. sham rats;
P < 0.05). In contrast, very low levels of RAMP3 mRNA were observed. RAMP3 mRNA levels, however, were elevated in both cardiomyocytes and non-cardiomyocytes from CHF rats (6.5-fold and 2.4-fold increase vs. sham rats, respectively;
P < 0.05). Parallel increases of specific AM receptor binding sites and of AM-stimulated adenylyl cyclase activities were observed in failing cardiomyocytes compared to cardiomyocytes from sham rats (fivefold and sixfold increase, respectively;
P < 0.05). Thus, this study demonstrates that AM mRNA levels, AM receptor binding sites, and AM-stimulated adenylyl cyclase activities are increased in cardiomyocytes from failing rat hearts. Furthermore, our data suggest that induction of RAMP2 and RAMP3 contributes to the increased responsiveness to AM in failing cardiomyocytes. |
| doi_str_mv | 10.1016/j.yjmcc.2004.10.009 |
| format | Article |
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P < 0.05). Fairly high mRNA levels and immunoreactivity against the AM receptor chaperone receptor activity-modifying protein-2 (RAMP2) were also detected in the cardiomyocytes and non-cardiomyocytes. However, induction of RAMP2 mRNA expression was restricted to cardiomyocytes (1.8-fold increase in cardiomyocytes from CHF rats vs. sham rats;
P < 0.05). In contrast, very low levels of RAMP3 mRNA were observed. RAMP3 mRNA levels, however, were elevated in both cardiomyocytes and non-cardiomyocytes from CHF rats (6.5-fold and 2.4-fold increase vs. sham rats, respectively;
P < 0.05). Parallel increases of specific AM receptor binding sites and of AM-stimulated adenylyl cyclase activities were observed in failing cardiomyocytes compared to cardiomyocytes from sham rats (fivefold and sixfold increase, respectively;
P < 0.05). Thus, this study demonstrates that AM mRNA levels, AM receptor binding sites, and AM-stimulated adenylyl cyclase activities are increased in cardiomyocytes from failing rat hearts. Furthermore, our data suggest that induction of RAMP2 and RAMP3 contributes to the increased responsiveness to AM in failing cardiomyocytes.</description><identifier>ISSN: 0022-2828</identifier><identifier>EISSN: 1095-8584</identifier><identifier>DOI: 10.1016/j.yjmcc.2004.10.009</identifier><identifier>PMID: 15623431</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adrenomedullin ; Animals ; Cardiomyocytes ; Gene Expression Regulation ; Heart - drug effects ; Heart - physiopathology ; Heart failure ; Heart Failure - metabolism ; Heart Failure - pathology ; Hemodynamics - drug effects ; Intracellular Signaling Peptides and Proteins ; Lung - pathology ; Male ; Membrane Proteins - analysis ; Membrane Proteins - genetics ; Membrane Proteins - immunology ; Membrane Proteins - metabolism ; Myocardium - metabolism ; Myocardium - pathology ; Organ Size ; Peptides - genetics ; Peptides - metabolism ; RAMP ; Rats ; Rats, Wistar ; Receptor Activity-Modifying Protein 2 ; Receptor Activity-Modifying Protein 3 ; Receptor Activity-Modifying Proteins ; Receptors, Adrenomedullin ; Receptors, Peptide - metabolism ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Signal Transduction</subject><ispartof>Journal of molecular and cellular cardiology, 2005, Vol.38 (1), p.145-151</ispartof><rights>2004 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c272t-3f9d8d988cd355a785527444258c272f9bb7ff3794f6f13aba84d9e4b3b348b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022282804003128$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27902,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15623431$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Øie, Erik</creatorcontrib><creatorcontrib>Vinge, Leif Erik</creatorcontrib><creatorcontrib>Andersen, Geir Øystein</creatorcontrib><creatorcontrib>Yndestad, Arne</creatorcontrib><creatorcontrib>Krobert, Kurt A.</creatorcontrib><creatorcontrib>Sandberg, Cecilie</creatorcontrib><creatorcontrib>Ahmed, Mohammed Shakil</creatorcontrib><creatorcontrib>Haug, Terje</creatorcontrib><creatorcontrib>Levy, Finn Olav</creatorcontrib><creatorcontrib>Skomedal, Tor</creatorcontrib><creatorcontrib>Attramadal, Håvard</creatorcontrib><title>RAMP2 and RAMP3 mRNA levels are increased in failing rat cardiomyocytes and associated with increased responsiveness to adrenomedullin</title><title>Journal of molecular and cellular cardiology</title><addtitle>J Mol Cell Cardiol</addtitle><description>Adrenomedullin (AM) is a potent vasorelaxing peptide with natriuretic and diuretic actions. Recent data indicate that AM may function as an endogenous regulator of cardiac function. We investigated to what extent AM, the AM receptor subtypes, and AM receptor-associated proteins were regulated in cardiomyocytes and non-cardiomyocytes of rats with congestive heart failure (CHF), and whether such regulation was paralleled by corresponding alterations of functional responses to AM. Cardiomyocytes and non-cardiomyocytes were isolated from myocardial tissue of rats 7 days after induction of myocardial infarction or sham operation. AM immunoreactivity was found in cardiomyocytes, endothelial cells, and fibroblasts. Robust increase of AM mRNA levels was observed both in the cardiomyocytes and in the non-cardiomyocytes of CHF rats compared to that of sham-operated rats (2.7-fold and 3.7-fold, respectively,
P < 0.05). Fairly high mRNA levels and immunoreactivity against the AM receptor chaperone receptor activity-modifying protein-2 (RAMP2) were also detected in the cardiomyocytes and non-cardiomyocytes. However, induction of RAMP2 mRNA expression was restricted to cardiomyocytes (1.8-fold increase in cardiomyocytes from CHF rats vs. sham rats;
P < 0.05). In contrast, very low levels of RAMP3 mRNA were observed. RAMP3 mRNA levels, however, were elevated in both cardiomyocytes and non-cardiomyocytes from CHF rats (6.5-fold and 2.4-fold increase vs. sham rats, respectively;
P < 0.05). Parallel increases of specific AM receptor binding sites and of AM-stimulated adenylyl cyclase activities were observed in failing cardiomyocytes compared to cardiomyocytes from sham rats (fivefold and sixfold increase, respectively;
P < 0.05). Thus, this study demonstrates that AM mRNA levels, AM receptor binding sites, and AM-stimulated adenylyl cyclase activities are increased in cardiomyocytes from failing rat hearts. Furthermore, our data suggest that induction of RAMP2 and RAMP3 contributes to the increased responsiveness to AM in failing cardiomyocytes.</description><subject>Adrenomedullin</subject><subject>Animals</subject><subject>Cardiomyocytes</subject><subject>Gene Expression Regulation</subject><subject>Heart - drug effects</subject><subject>Heart - physiopathology</subject><subject>Heart failure</subject><subject>Heart Failure - metabolism</subject><subject>Heart Failure - pathology</subject><subject>Hemodynamics - drug effects</subject><subject>Intracellular Signaling Peptides and Proteins</subject><subject>Lung - pathology</subject><subject>Male</subject><subject>Membrane Proteins - analysis</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - immunology</subject><subject>Membrane Proteins - metabolism</subject><subject>Myocardium - metabolism</subject><subject>Myocardium - pathology</subject><subject>Organ Size</subject><subject>Peptides - genetics</subject><subject>Peptides - metabolism</subject><subject>RAMP</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptor Activity-Modifying Protein 2</subject><subject>Receptor Activity-Modifying Protein 3</subject><subject>Receptor Activity-Modifying Proteins</subject><subject>Receptors, Adrenomedullin</subject><subject>Receptors, Peptide - metabolism</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Signal Transduction</subject><issn>0022-2828</issn><issn>1095-8584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1qGzEURkVpaJy0T1AoWnU3jkbSeDSLLkxIm0B-SsheaKSrVmZm5OqOHfwCee5obEO6ykqXy_k-cQ8hX0s2L1m5uFjNd6ve2jlnTObNnLHmA5mVrKkKVSn5kcwY47zgiqtTcoa4YpmQQnwip2W14EKKckZeHpd3vzk1g6PTJGj_eL-kHWyhQ2oS0DDYBAbB5Yl6E7ow_KHJjNSa5ELsd9HuRsB9g0GMNpgxw89h_PtfNgGu44BhCwMg0jFS4xIMsQe36XLlZ3LiTYfw5fiek6efV0-X18Xtw6-by-VtYXnNx0L4xinXKGWdqCpTq6ritZSSV2oCfNO2tfeibqRf-FKY1ijpGpCtaIVUrTgn3w-16xT_bQBH3Qe00HVmgLhBvagzxoXIoDiANkXEBF6vU-hN2umS6cm-Xum9fT3Zn5bZbU59O9Zv2nzZW-aoOwM_DkC2C9sASaMNMFhwIYEdtYvh3Q9eAQkVmHo</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Øie, Erik</creator><creator>Vinge, Leif Erik</creator><creator>Andersen, Geir Øystein</creator><creator>Yndestad, Arne</creator><creator>Krobert, Kurt A.</creator><creator>Sandberg, Cecilie</creator><creator>Ahmed, Mohammed Shakil</creator><creator>Haug, Terje</creator><creator>Levy, Finn Olav</creator><creator>Skomedal, Tor</creator><creator>Attramadal, Håvard</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2005</creationdate><title>RAMP2 and RAMP3 mRNA levels are increased in failing rat cardiomyocytes and associated with increased responsiveness to adrenomedullin</title><author>Øie, Erik ; Vinge, Leif Erik ; Andersen, Geir Øystein ; Yndestad, Arne ; Krobert, Kurt A. ; Sandberg, Cecilie ; Ahmed, Mohammed Shakil ; Haug, Terje ; Levy, Finn Olav ; Skomedal, Tor ; Attramadal, Håvard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-3f9d8d988cd355a785527444258c272f9bb7ff3794f6f13aba84d9e4b3b348b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adrenomedullin</topic><topic>Animals</topic><topic>Cardiomyocytes</topic><topic>Gene Expression Regulation</topic><topic>Heart - drug effects</topic><topic>Heart - physiopathology</topic><topic>Heart failure</topic><topic>Heart Failure - metabolism</topic><topic>Heart Failure - pathology</topic><topic>Hemodynamics - drug effects</topic><topic>Intracellular Signaling Peptides and Proteins</topic><topic>Lung - pathology</topic><topic>Male</topic><topic>Membrane Proteins - analysis</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - immunology</topic><topic>Membrane Proteins - metabolism</topic><topic>Myocardium - metabolism</topic><topic>Myocardium - pathology</topic><topic>Organ Size</topic><topic>Peptides - genetics</topic><topic>Peptides - metabolism</topic><topic>RAMP</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptor Activity-Modifying Protein 2</topic><topic>Receptor Activity-Modifying Protein 3</topic><topic>Receptor Activity-Modifying Proteins</topic><topic>Receptors, Adrenomedullin</topic><topic>Receptors, Peptide - metabolism</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Øie, Erik</creatorcontrib><creatorcontrib>Vinge, Leif Erik</creatorcontrib><creatorcontrib>Andersen, Geir Øystein</creatorcontrib><creatorcontrib>Yndestad, Arne</creatorcontrib><creatorcontrib>Krobert, Kurt A.</creatorcontrib><creatorcontrib>Sandberg, Cecilie</creatorcontrib><creatorcontrib>Ahmed, Mohammed Shakil</creatorcontrib><creatorcontrib>Haug, Terje</creatorcontrib><creatorcontrib>Levy, Finn Olav</creatorcontrib><creatorcontrib>Skomedal, Tor</creatorcontrib><creatorcontrib>Attramadal, Håvard</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of molecular and cellular cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Øie, Erik</au><au>Vinge, Leif Erik</au><au>Andersen, Geir Øystein</au><au>Yndestad, Arne</au><au>Krobert, Kurt A.</au><au>Sandberg, Cecilie</au><au>Ahmed, Mohammed Shakil</au><au>Haug, Terje</au><au>Levy, Finn Olav</au><au>Skomedal, Tor</au><au>Attramadal, Håvard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>RAMP2 and RAMP3 mRNA levels are increased in failing rat cardiomyocytes and associated with increased responsiveness to adrenomedullin</atitle><jtitle>Journal of molecular and cellular cardiology</jtitle><addtitle>J Mol Cell Cardiol</addtitle><date>2005</date><risdate>2005</risdate><volume>38</volume><issue>1</issue><spage>145</spage><epage>151</epage><pages>145-151</pages><issn>0022-2828</issn><eissn>1095-8584</eissn><abstract>Adrenomedullin (AM) is a potent vasorelaxing peptide with natriuretic and diuretic actions. Recent data indicate that AM may function as an endogenous regulator of cardiac function. We investigated to what extent AM, the AM receptor subtypes, and AM receptor-associated proteins were regulated in cardiomyocytes and non-cardiomyocytes of rats with congestive heart failure (CHF), and whether such regulation was paralleled by corresponding alterations of functional responses to AM. Cardiomyocytes and non-cardiomyocytes were isolated from myocardial tissue of rats 7 days after induction of myocardial infarction or sham operation. AM immunoreactivity was found in cardiomyocytes, endothelial cells, and fibroblasts. Robust increase of AM mRNA levels was observed both in the cardiomyocytes and in the non-cardiomyocytes of CHF rats compared to that of sham-operated rats (2.7-fold and 3.7-fold, respectively,
P < 0.05). Fairly high mRNA levels and immunoreactivity against the AM receptor chaperone receptor activity-modifying protein-2 (RAMP2) were also detected in the cardiomyocytes and non-cardiomyocytes. However, induction of RAMP2 mRNA expression was restricted to cardiomyocytes (1.8-fold increase in cardiomyocytes from CHF rats vs. sham rats;
P < 0.05). In contrast, very low levels of RAMP3 mRNA were observed. RAMP3 mRNA levels, however, were elevated in both cardiomyocytes and non-cardiomyocytes from CHF rats (6.5-fold and 2.4-fold increase vs. sham rats, respectively;
P < 0.05). Parallel increases of specific AM receptor binding sites and of AM-stimulated adenylyl cyclase activities were observed in failing cardiomyocytes compared to cardiomyocytes from sham rats (fivefold and sixfold increase, respectively;
P < 0.05). Thus, this study demonstrates that AM mRNA levels, AM receptor binding sites, and AM-stimulated adenylyl cyclase activities are increased in cardiomyocytes from failing rat hearts. Furthermore, our data suggest that induction of RAMP2 and RAMP3 contributes to the increased responsiveness to AM in failing cardiomyocytes.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>15623431</pmid><doi>10.1016/j.yjmcc.2004.10.009</doi><tpages>7</tpages></addata></record> |
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| subjects | Adrenomedullin Animals Cardiomyocytes Gene Expression Regulation Heart - drug effects Heart - physiopathology Heart failure Heart Failure - metabolism Heart Failure - pathology Hemodynamics - drug effects Intracellular Signaling Peptides and Proteins Lung - pathology Male Membrane Proteins - analysis Membrane Proteins - genetics Membrane Proteins - immunology Membrane Proteins - metabolism Myocardium - metabolism Myocardium - pathology Organ Size Peptides - genetics Peptides - metabolism RAMP Rats Rats, Wistar Receptor Activity-Modifying Protein 2 Receptor Activity-Modifying Protein 3 Receptor Activity-Modifying Proteins Receptors, Adrenomedullin Receptors, Peptide - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction |
| title | RAMP2 and RAMP3 mRNA levels are increased in failing rat cardiomyocytes and associated with increased responsiveness to adrenomedullin |
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