Prone position prevents regional alveolar hyperinflation and mechanical stress and strain in mild experimental acute lung injury
Abstract Prone position may delay the development of ventilator-induced lung injury (VILI), but the mechanisms require better elucidation. In experimental mild acute lung injury (ALI), arterial oxygen partial pressure ( P a O 2 ), lung mechanics and histology, inflammatory markers [interleukin (IL)-...
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| Veröffentlicht in: | Respiratory physiology & neurobiology 2009-06, Vol.167 (2), p.181-188 |
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| creator | Santana, Maria Cristina E Garcia, Cristiane S.N.B Xisto, Débora G Nagato, Lilian K.S Lassance, Roberta M Prota, Luiz Felipe M Ornellas, Felipe M Capelozzi, Vera L Morales, Marcelo M Zin, Walter A Pelosi, Paolo Rocco, Patricia R.M |
| description | Abstract Prone position may delay the development of ventilator-induced lung injury (VILI), but the mechanisms require better elucidation. In experimental mild acute lung injury (ALI), arterial oxygen partial pressure ( P a O 2 ), lung mechanics and histology, inflammatory markers [interleukin (IL)-6 and IL-1β], and type III procollagen (PCIII) mRNA expressions were analysed in supine and prone position. Wistar rats were randomly divided into two groups. In controls, saline was intraperitoneally injected while ALI was induced by paraquat. After 24-h, the animals were mechanically ventilated for 1-h in supine or prone positions. In ALI, prone position led to a better blood flow/tissue ratio both in ventral and dorsal regions and was associated with a more homogeneous distribution of alveolar aeration/tissue ratio reducing lung static elastance and viscoelastic pressure, and increasing end-expiratory lung volume and P a O 2 . PCIII expression was higher in the ventral than dorsal region in supine position, with no regional changes in inflammatory markers. In conclusion, prone position may protect the lungs against VILI, thus reducing pulmonary stress and strain. |
| doi_str_mv | 10.1016/j.resp.2009.04.006 |
| format | Article |
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In experimental mild acute lung injury (ALI), arterial oxygen partial pressure ( P a O 2 ), lung mechanics and histology, inflammatory markers [interleukin (IL)-6 and IL-1β], and type III procollagen (PCIII) mRNA expressions were analysed in supine and prone position. Wistar rats were randomly divided into two groups. In controls, saline was intraperitoneally injected while ALI was induced by paraquat. After 24-h, the animals were mechanically ventilated for 1-h in supine or prone positions. In ALI, prone position led to a better blood flow/tissue ratio both in ventral and dorsal regions and was associated with a more homogeneous distribution of alveolar aeration/tissue ratio reducing lung static elastance and viscoelastic pressure, and increasing end-expiratory lung volume and P a O 2 . PCIII expression was higher in the ventral than dorsal region in supine position, with no regional changes in inflammatory markers. In conclusion, prone position may protect the lungs against VILI, thus reducing pulmonary stress and strain.</description><identifier>ISSN: 1569-9048</identifier><identifier>EISSN: 1878-1519</identifier><identifier>DOI: 10.1016/j.resp.2009.04.006</identifier><identifier>PMID: 19505674</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Acute Lung Injury - metabolism ; Acute Lung Injury - pathology ; Acute Lung Injury - physiopathology ; Animals ; Biological and medical sciences ; Female ; Fundamental and applied biological sciences. Psychology ; Gas-exchange ; Inflammation Mediators - metabolism ; Interleukin-1beta - biosynthesis ; Interleukin-6 - biosynthesis ; Lung histopathology ; Lung mechanics ; Medical Education ; Oxygen ; Partial Pressure ; Procollagen - biosynthesis ; Prone Position - physiology ; Pulmonary Alveoli - physiopathology ; Pulmonary/Respiratory ; Rats ; Rats, Wistar ; Respiratory Mechanics - physiology ; RNA, Messenger - analysis ; Tissue stress and strain ; Ventilator-induced lung injury ; Vertebrates: respiratory system ; Vital Capacity - physiology</subject><ispartof>Respiratory physiology & neurobiology, 2009-06, Vol.167 (2), p.181-188</ispartof><rights>Elsevier B.V.</rights><rights>2009 Elsevier B.V.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-b50f8c76f59534a1ee589ccf167a9783a2fd92493e1e8ab7f2bb88c1c80ddef13</citedby><cites>FETCH-LOGICAL-c439t-b50f8c76f59534a1ee589ccf167a9783a2fd92493e1e8ab7f2bb88c1c80ddef13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.resp.2009.04.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21723026$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19505674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santana, Maria Cristina E</creatorcontrib><creatorcontrib>Garcia, Cristiane S.N.B</creatorcontrib><creatorcontrib>Xisto, Débora G</creatorcontrib><creatorcontrib>Nagato, Lilian K.S</creatorcontrib><creatorcontrib>Lassance, Roberta M</creatorcontrib><creatorcontrib>Prota, Luiz Felipe M</creatorcontrib><creatorcontrib>Ornellas, Felipe M</creatorcontrib><creatorcontrib>Capelozzi, Vera L</creatorcontrib><creatorcontrib>Morales, Marcelo M</creatorcontrib><creatorcontrib>Zin, Walter A</creatorcontrib><creatorcontrib>Pelosi, Paolo</creatorcontrib><creatorcontrib>Rocco, Patricia R.M</creatorcontrib><title>Prone position prevents regional alveolar hyperinflation and mechanical stress and strain in mild experimental acute lung injury</title><title>Respiratory physiology & neurobiology</title><addtitle>Respir Physiol Neurobiol</addtitle><description>Abstract Prone position may delay the development of ventilator-induced lung injury (VILI), but the mechanisms require better elucidation. In experimental mild acute lung injury (ALI), arterial oxygen partial pressure ( P a O 2 ), lung mechanics and histology, inflammatory markers [interleukin (IL)-6 and IL-1β], and type III procollagen (PCIII) mRNA expressions were analysed in supine and prone position. Wistar rats were randomly divided into two groups. In controls, saline was intraperitoneally injected while ALI was induced by paraquat. After 24-h, the animals were mechanically ventilated for 1-h in supine or prone positions. In ALI, prone position led to a better blood flow/tissue ratio both in ventral and dorsal regions and was associated with a more homogeneous distribution of alveolar aeration/tissue ratio reducing lung static elastance and viscoelastic pressure, and increasing end-expiratory lung volume and P a O 2 . PCIII expression was higher in the ventral than dorsal region in supine position, with no regional changes in inflammatory markers. In conclusion, prone position may protect the lungs against VILI, thus reducing pulmonary stress and strain.</description><subject>Acute Lung Injury - metabolism</subject><subject>Acute Lung Injury - pathology</subject><subject>Acute Lung Injury - physiopathology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gas-exchange</subject><subject>Inflammation Mediators - metabolism</subject><subject>Interleukin-1beta - biosynthesis</subject><subject>Interleukin-6 - biosynthesis</subject><subject>Lung histopathology</subject><subject>Lung mechanics</subject><subject>Medical Education</subject><subject>Oxygen</subject><subject>Partial Pressure</subject><subject>Procollagen - biosynthesis</subject><subject>Prone Position - physiology</subject><subject>Pulmonary Alveoli - physiopathology</subject><subject>Pulmonary/Respiratory</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Respiratory Mechanics - physiology</subject><subject>RNA, Messenger - analysis</subject><subject>Tissue stress and strain</subject><subject>Ventilator-induced lung injury</subject><subject>Vertebrates: respiratory system</subject><subject>Vital Capacity - physiology</subject><issn>1569-9048</issn><issn>1878-1519</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk-L1TAUxYsozjj6BVxIN7prJ2naJgERZPAfDDgwug5pejOTmqY1t334dvPRTd97KLgQArlJfudwOTdZ9pKSkhLaXg5lBJzLihBZkrokpH2UnVPBRUEbKh-numllIUktzrJniAMhlFPOnmZnVDakaXl9nj3cxClAPk_oFjeFfI6wg7BgHuEunbXPtd_B5HXM7_czRBes1wdShz4fwdzr4EzCcEnN4OE2ldqFPK3R-T6HX5tuTK6bm1kXyP0a7tL7sMb98-yJ1R7hxWm_yL5__PDt6nNx_fXTl6v314WpmVyKriFWGN7aRjas1hSgEdIYS1uuJRdMV7aXVS0ZUBC647bqOiEMNYL0PVjKLrI3R985Tj9XwEWNDg14rwNMK6qWs5ozzhJYHUETJ8QIVs2pex33ihK15a4GteWuttwVqVXKPYlendzXboT-r-QUdAJenwCNKS4bdTAO_3AV5RUj1Wb09shBymLnICo0DoKB3kUwi-on9_8-3v0jN94dBvQD9oDDtMY0U1RUYaWIut1-yPZBiCTJhTL2G8xJufU</recordid><startdate>20090630</startdate><enddate>20090630</enddate><creator>Santana, Maria Cristina E</creator><creator>Garcia, Cristiane S.N.B</creator><creator>Xisto, Débora G</creator><creator>Nagato, Lilian K.S</creator><creator>Lassance, Roberta M</creator><creator>Prota, Luiz Felipe M</creator><creator>Ornellas, Felipe M</creator><creator>Capelozzi, Vera L</creator><creator>Morales, Marcelo M</creator><creator>Zin, Walter A</creator><creator>Pelosi, Paolo</creator><creator>Rocco, Patricia R.M</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090630</creationdate><title>Prone position prevents regional alveolar hyperinflation and mechanical stress and strain in mild experimental acute lung injury</title><author>Santana, Maria Cristina E ; Garcia, Cristiane S.N.B ; Xisto, Débora G ; Nagato, Lilian K.S ; Lassance, Roberta M ; Prota, Luiz Felipe M ; Ornellas, Felipe M ; Capelozzi, Vera L ; Morales, Marcelo M ; Zin, Walter A ; Pelosi, Paolo ; Rocco, Patricia R.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-b50f8c76f59534a1ee589ccf167a9783a2fd92493e1e8ab7f2bb88c1c80ddef13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acute Lung Injury - metabolism</topic><topic>Acute Lung Injury - pathology</topic><topic>Acute Lung Injury - physiopathology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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In experimental mild acute lung injury (ALI), arterial oxygen partial pressure ( P a O 2 ), lung mechanics and histology, inflammatory markers [interleukin (IL)-6 and IL-1β], and type III procollagen (PCIII) mRNA expressions were analysed in supine and prone position. Wistar rats were randomly divided into two groups. In controls, saline was intraperitoneally injected while ALI was induced by paraquat. After 24-h, the animals were mechanically ventilated for 1-h in supine or prone positions. In ALI, prone position led to a better blood flow/tissue ratio both in ventral and dorsal regions and was associated with a more homogeneous distribution of alveolar aeration/tissue ratio reducing lung static elastance and viscoelastic pressure, and increasing end-expiratory lung volume and P a O 2 . PCIII expression was higher in the ventral than dorsal region in supine position, with no regional changes in inflammatory markers. In conclusion, prone position may protect the lungs against VILI, thus reducing pulmonary stress and strain.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>19505674</pmid><doi>10.1016/j.resp.2009.04.006</doi><tpages>8</tpages></addata></record> |
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| subjects | Acute Lung Injury - metabolism Acute Lung Injury - pathology Acute Lung Injury - physiopathology Animals Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Gas-exchange Inflammation Mediators - metabolism Interleukin-1beta - biosynthesis Interleukin-6 - biosynthesis Lung histopathology Lung mechanics Medical Education Oxygen Partial Pressure Procollagen - biosynthesis Prone Position - physiology Pulmonary Alveoli - physiopathology Pulmonary/Respiratory Rats Rats, Wistar Respiratory Mechanics - physiology RNA, Messenger - analysis Tissue stress and strain Ventilator-induced lung injury Vertebrates: respiratory system Vital Capacity - physiology |
| title | Prone position prevents regional alveolar hyperinflation and mechanical stress and strain in mild experimental acute lung injury |
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