Dual Effect of Synthetic Aminoglycosides: Antibacterial Activity against Bacillus anthracis and Inhibition of Anthrax Lethal Factor

Defence against bioterrorism: Recent events have created an urgent need for therapeutic strategies to treat anthrax, an infectious disease caused by the toxigenic bacterium Bacillus anthracis. A new class of aminoglycosides (see picture) are powerful inhibitors under physiological conditions of the...

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Veröffentlicht in:	Angewandte Chemie International Edition 2005-01, Vol.44 (3), p.447-452
Hauptverfasser:	Fridman, Micha, Belakhov, Valery, Lee, Lac V., Liang, Fu-Sen, Wong, Chi-Huey, Baasov, Timor
Format:	Artikel
Sprache:	eng
Schlagworte:	aminoglycosides Aminoglycosides - pharmacology anthrax Anti-Bacterial Agents - pharmacology antibiotics Antigens, Bacterial Bacillus anthracis Bacillus anthracis - drug effects Bacterial Toxins - antagonists & inhibitors inhibitors Microbial Sensitivity Tests Surface Plasmon Resonance
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description	Defence against bioterrorism: Recent events have created an urgent need for therapeutic strategies to treat anthrax, an infectious disease caused by the toxigenic bacterium Bacillus anthracis. A new class of aminoglycosides (see picture) are powerful inhibitors under physiological conditions of the anthrax lethal factor, which has a major role in the disease, and function simultaneously as antibiotics against B. anthracis.
doi_str_mv	10.1002/anie.200462003
format	Article
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source	MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects	aminoglycosides Aminoglycosides - pharmacology anthrax Anti-Bacterial Agents - pharmacology antibiotics Antigens, Bacterial Bacillus anthracis Bacillus anthracis - drug effects Bacterial Toxins - antagonists & inhibitors inhibitors Microbial Sensitivity Tests Surface Plasmon Resonance
title	Dual Effect of Synthetic Aminoglycosides: Antibacterial Activity against Bacillus anthracis and Inhibition of Anthrax Lethal Factor
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