Protein‐free ligand screening: simplification of chiral chromatographic development via novel adaptation of NMR screening methodologies

We demonstrate here a promising NMR method that provides evidence for chiral compound selector interaction as a first‐pass screening method. A novel adaptation of commonly used protein‐based screening technologies, this approach relies upon ligand‐to‐stationary phase interaction wherein the stationa...

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Veröffentlicht in:	Magnetic resonance in chemistry 2009-07, Vol.47 (7), p.541-550
Hauptverfasser:	Thompson, Melissa R., McKenzie, David R., Likos, John J., Gard, Janice K.
Format:	Artikel
Sprache:	eng
Schlagworte:	chiral chromatographic screening Chromatography CSP chiral stationary phase Isomerism Ligands NMR Nuclear Magnetic Resonance, Biomolecular - methods Proteins - chemistry saturation transfer difference STD
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