Expression of functional interleukin‐21 receptor on adult T‐cell leukaemia cells

Summary Adult T‐cell leukaemia (ATL) is caused by human T‐cell leukaemia virus type I (HTLV‐I). It has been suggested that cytokines play a role in the development and in the neoplastic cell growth of ATL. However, the precise mechanism involved in this process still remains unclear. Interleukin‐21...

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Veröffentlicht in:	British journal of haematology 2005-01, Vol.128 (2), p.169-176
Hauptverfasser:	Ueda, Maki, Imada, Kazunori, Imura, Akihiro, Koga, Hikari, Hishizawa, Masakatsu, Uchiyama, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult adult T‐cell leukaemia Biological and medical sciences Blotting, Western - methods Cell Line, Transformed Cell Line, Tumor Cell Proliferation cytokine receptors DNA-Binding Proteins - metabolism Flow Cytometry Hematologic and hematopoietic diseases Hematology Human T-lymphotropic virus 1 human T‐cell leukaemia virus type I Humans Interleukin-21 Receptor alpha Subunit interleukins Leukemia, T-Cell - immunology Leukemia, T-Cell - pathology Leukemia, T-Cell - virology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Milk Proteins - metabolism Phosphorylation Receptors, Interleukin - genetics Receptors, Interleukin-21 Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Signal Transduction STAT3 Transcription Factor STAT5 Transcription Factor T-Lymphocytes - immunology Trans-Activators - metabolism
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