Neuropeptide Y and Leptin in Patients with Obstructive Sleep Apnea Syndrome: Role of Obesity
Neuropeptide Y (NPY) and leptin are two peptides involved in the regulation of body weight, energy balance, and sympathetic tone. This study investigates the independent role of apneas and obesity on NPY and leptin plasma levels in patients with obstructive sleep apnea syndrome (OSAS). To this end w...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 2005-01, Vol.171 (2), p.183-187 |
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| container_title | American journal of respiratory and critical care medicine |
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| creator | Barcelo, Antonia Barbe, Ferran Llompart, Elena de la Pena, Monica Duran-Cantolla, Joaquin Ladaria, Antoni Bosch, Margalida Guerra, Lourdes Agusti, Alvar G. N |
| description | Neuropeptide Y (NPY) and leptin are two peptides involved in the regulation of body weight, energy balance, and sympathetic tone. This study investigates the independent role of apneas and obesity on NPY and leptin plasma levels in patients with obstructive sleep apnea syndrome (OSAS). To this end we compared their values in 23 obese (body mass index > 30 kg/m2) and 24 nonobese (body mass index < 27 kg/m2) patients with OSAS, and in 19 obese and 18 nonobese control subjects without OSAS. Patients who used continuous positive airway pressure for more than 4 hours/night were reexamined 3 and 12 months later. We found that NPY levels were increased (p < 0.01) in patients with OSAS independently of obesity. Leptin levels were also increased in OSAS but this was mostly associated to obesity. Continuous positive airway pressure treatment reduced NPY levels in all patients and leptin levels only in nonobese patients (p < 0.01). We concluded that NPY and leptin plasma levels are increased in patients with OSAS. Yet, whereas the former appear independent of obesity, the latter are mostly associated with obesity. |
| doi_str_mv | 10.1164/rccm.200405-579OC |
| format | Article |
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Leptin levels were also increased in OSAS but this was mostly associated to obesity. Continuous positive airway pressure treatment reduced NPY levels in all patients and leptin levels only in nonobese patients (p < 0.01). We concluded that NPY and leptin plasma levels are increased in patients with OSAS. 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N</creatorcontrib><title>Neuropeptide Y and Leptin in Patients with Obstructive Sleep Apnea Syndrome: Role of Obesity</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>Neuropeptide Y (NPY) and leptin are two peptides involved in the regulation of body weight, energy balance, and sympathetic tone. This study investigates the independent role of apneas and obesity on NPY and leptin plasma levels in patients with obstructive sleep apnea syndrome (OSAS). To this end we compared their values in 23 obese (body mass index > 30 kg/m2) and 24 nonobese (body mass index < 27 kg/m2) patients with OSAS, and in 19 obese and 18 nonobese control subjects without OSAS. Patients who used continuous positive airway pressure for more than 4 hours/night were reexamined 3 and 12 months later. We found that NPY levels were increased (p < 0.01) in patients with OSAS independently of obesity. Leptin levels were also increased in OSAS but this was mostly associated to obesity. Continuous positive airway pressure treatment reduced NPY levels in all patients and leptin levels only in nonobese patients (p < 0.01). We concluded that NPY and leptin plasma levels are increased in patients with OSAS. Yet, whereas the former appear independent of obesity, the latter are mostly associated with obesity.</description><subject>Airway management</subject><subject>Analysis of Variance</subject><subject>Biomarkers</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Case-Control Studies</subject><subject>Chronic illnesses</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Consent</subject><subject>Continuous Positive Airway Pressure</subject><subject>Diabetes</subject><subject>Humans</subject><subject>Leptin - blood</subject><subject>Liver cirrhosis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neuropeptide Y - blood</subject><subject>Neuropeptides</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Peptides</subject><subject>Plasma</subject><subject>Prospective Studies</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - blood</subject><subject>Sleep Apnea, Obstructive - therapy</subject><subject>Statistics, Nonparametric</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkFtrFEEQRgdRTIz-AF-k8UHwYZKuvrdvYfEGixtMHhSEpqen1u1lbnbPJOy_d8ZdCAgFVQWnPopTFK-BXgIocZVCaC8ZpYLKUmq7WT0pzkFyWQqr6dN5ppqXQtgfZ8WLnPeUAjNAnxdnICUoydV58esbTqkfcBhjjeQn8V1N1svWkblu_BixGzN5iOOObKo8pimM8R7JbYM4kOuhQ09uD12d-hY_kO99g6TfziTmOB5eFs-2vsn46tQvirtPH-9WX8r15vPX1fW6DBzYWFpZiQAcBFYgKms0IKu1MgZqLatguOVQBWQ6eCNhq5k2nmmLqAxg0PyieHeMHVL_Z8I8ujbmgE3jO-yn7JTmQlG-gG__A_f9lLr5NQfWKmaV4jMERyikPueEWzek2Pp0cEDdot0t2t1Ru_unfb55cwqeqhbrx4uT5xl4fwR28ffuISZ0ufVNM-Pg_H4JBA2OOTCc_wUDC4wm</recordid><startdate>20050115</startdate><enddate>20050115</enddate><creator>Barcelo, Antonia</creator><creator>Barbe, Ferran</creator><creator>Llompart, Elena</creator><creator>de la Pena, Monica</creator><creator>Duran-Cantolla, Joaquin</creator><creator>Ladaria, Antoni</creator><creator>Bosch, Margalida</creator><creator>Guerra, Lourdes</creator><creator>Agusti, Alvar G. 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Patients who used continuous positive airway pressure for more than 4 hours/night were reexamined 3 and 12 months later. We found that NPY levels were increased (p < 0.01) in patients with OSAS independently of obesity. Leptin levels were also increased in OSAS but this was mostly associated to obesity. Continuous positive airway pressure treatment reduced NPY levels in all patients and leptin levels only in nonobese patients (p < 0.01). We concluded that NPY and leptin plasma levels are increased in patients with OSAS. Yet, whereas the former appear independent of obesity, the latter are mostly associated with obesity.</abstract><cop>United States</cop><pub>Am Thoracic Soc</pub><pmid>15516536</pmid><doi>10.1164/rccm.200405-579OC</doi><tpages>5</tpages></addata></record> |
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| ispartof | American journal of respiratory and critical care medicine, 2005-01, Vol.171 (2), p.183-187 |
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| source | MEDLINE; Journals@Ovid Ovid Autoload; American Thoracic Society (ATS) Journals Online; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Airway management Analysis of Variance Biomarkers Blood pressure Body mass index Case-Control Studies Chronic illnesses Chronic obstructive pulmonary disease Consent Continuous Positive Airway Pressure Diabetes Humans Leptin - blood Liver cirrhosis Male Middle Aged Neuropeptide Y - blood Neuropeptides Obesity Obesity - blood Peptides Plasma Prospective Studies Sleep apnea Sleep Apnea, Obstructive - blood Sleep Apnea, Obstructive - therapy Statistics, Nonparametric |
| title | Neuropeptide Y and Leptin in Patients with Obstructive Sleep Apnea Syndrome: Role of Obesity |
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