Anti-inflammatory and antiviral effects of Glossogyne tenuifolia
Glossogyne tenuifolia ( Hsiang-Ju) is a traditional antipyretic and hepatoprotective herb used in Chinese medicine. The aim of this research is to investigate the pharmacological activities and potent components of the ethanol extract of Glossogyne tenuifolia (GT) in human primary cells and cell lin...
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| Veröffentlicht in: | Life sciences (1973) 2005-01, Vol.76 (10), p.1135-1146 |
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| creator | Wu, Ming-Jiuan Weng, Ching-Yi Ding, Hsiou-Yu Wu, Pei-Jong |
| description | Glossogyne tenuifolia (
Hsiang-Ju) is a traditional antipyretic and hepatoprotective herb used in Chinese medicine. The aim of this research is to investigate the pharmacological activities and potent components of the ethanol extract of
Glossogyne tenuifolia (GT) in human primary cells and cell line. We found that GT (0.1 ∼ 0.25 mg/ml) exerted dose-dependent inhibitions on the release of TNF-α and IL-6 in LPS-activated human whole blood and peripheral blood mononuclear cells (PBMC), and IFN-γ in PHA-stimulated human whole blood. The lack of cytotoxicity indicated that the inhibitory effects of GT on cytokine production were not due to cell death. Luteolin, the deglycosylated derivative of one of the major compositions, luteolin-7-glucoside, exerted inhibitory effects on TNF-α, IL-6 and IFN-γ production in activated human whole blood with estimated IC
50s of 42.73 μM, 44.86 μM and 3.34 μM, respectively. Furthermore, GT had potent anti-hepatitis B virus (HBV) effects on the human hepatocellular carcinoma cell line, PLC/PRF/5. GT exhibited a dose-dependent inhibition on the release of hepatitis B surface antigen (HBsAg) by repressing the expression of HBsAg with IC
50 of 0.093 mg/ml. We concluded that GT exerted combinatorial anti-inflammatory and antiviral effects, and the multiple actions may underlie its traditional hepatoprotective function. |
| doi_str_mv | 10.1016/j.lfs.2004.08.017 |
| format | Article |
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Hsiang-Ju) is a traditional antipyretic and hepatoprotective herb used in Chinese medicine. The aim of this research is to investigate the pharmacological activities and potent components of the ethanol extract of
Glossogyne tenuifolia (GT) in human primary cells and cell line. We found that GT (0.1 ∼ 0.25 mg/ml) exerted dose-dependent inhibitions on the release of TNF-α and IL-6 in LPS-activated human whole blood and peripheral blood mononuclear cells (PBMC), and IFN-γ in PHA-stimulated human whole blood. The lack of cytotoxicity indicated that the inhibitory effects of GT on cytokine production were not due to cell death. Luteolin, the deglycosylated derivative of one of the major compositions, luteolin-7-glucoside, exerted inhibitory effects on TNF-α, IL-6 and IFN-γ production in activated human whole blood with estimated IC
50s of 42.73 μM, 44.86 μM and 3.34 μM, respectively. Furthermore, GT had potent anti-hepatitis B virus (HBV) effects on the human hepatocellular carcinoma cell line, PLC/PRF/5. GT exhibited a dose-dependent inhibition on the release of hepatitis B surface antigen (HBsAg) by repressing the expression of HBsAg with IC
50 of 0.093 mg/ml. We concluded that GT exerted combinatorial anti-inflammatory and antiviral effects, and the multiple actions may underlie its traditional hepatoprotective function.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2004.08.017</identifier><identifier>PMID: 15620577</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Anti-Inflammatory Agents - pharmacology ; Antiviral Agents - pharmacology ; Cells, Cultured ; Cytokines - biosynthesis ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal - pharmacology ; HBsAg ; Hepatitis B Surface Antigens - biosynthesis ; Hepatitis B virus ; Humans ; IFN-γ ; IL-6 ; TNF-α</subject><ispartof>Life sciences (1973), 2005-01, Vol.76 (10), p.1135-1146</ispartof><rights>2004 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-c47f270c860d3c6acfde6a6ef60e5e80359540cdf83e1ffefaa52f90b5172f7f3</citedby><cites>FETCH-LOGICAL-c448t-c47f270c860d3c6acfde6a6ef60e5e80359540cdf83e1ffefaa52f90b5172f7f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.lfs.2004.08.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15620577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Ming-Jiuan</creatorcontrib><creatorcontrib>Weng, Ching-Yi</creatorcontrib><creatorcontrib>Ding, Hsiou-Yu</creatorcontrib><creatorcontrib>Wu, Pei-Jong</creatorcontrib><title>Anti-inflammatory and antiviral effects of Glossogyne tenuifolia</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Glossogyne tenuifolia (
Hsiang-Ju) is a traditional antipyretic and hepatoprotective herb used in Chinese medicine. The aim of this research is to investigate the pharmacological activities and potent components of the ethanol extract of
Glossogyne tenuifolia (GT) in human primary cells and cell line. We found that GT (0.1 ∼ 0.25 mg/ml) exerted dose-dependent inhibitions on the release of TNF-α and IL-6 in LPS-activated human whole blood and peripheral blood mononuclear cells (PBMC), and IFN-γ in PHA-stimulated human whole blood. The lack of cytotoxicity indicated that the inhibitory effects of GT on cytokine production were not due to cell death. Luteolin, the deglycosylated derivative of one of the major compositions, luteolin-7-glucoside, exerted inhibitory effects on TNF-α, IL-6 and IFN-γ production in activated human whole blood with estimated IC
50s of 42.73 μM, 44.86 μM and 3.34 μM, respectively. Furthermore, GT had potent anti-hepatitis B virus (HBV) effects on the human hepatocellular carcinoma cell line, PLC/PRF/5. GT exhibited a dose-dependent inhibition on the release of hepatitis B surface antigen (HBsAg) by repressing the expression of HBsAg with IC
50 of 0.093 mg/ml. We concluded that GT exerted combinatorial anti-inflammatory and antiviral effects, and the multiple actions may underlie its traditional hepatoprotective function.</description><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antiviral Agents - pharmacology</subject><subject>Cells, Cultured</subject><subject>Cytokines - biosynthesis</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>HBsAg</subject><subject>Hepatitis B Surface Antigens - biosynthesis</subject><subject>Hepatitis B virus</subject><subject>Humans</subject><subject>IFN-γ</subject><subject>IL-6</subject><subject>TNF-α</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFLwzAYhoMobk5_gBfpyVvrl6ZJOrw4hk5h4EXPIUu_SEbazqQb7N-bsYE3PSSB8Lzvx_cQckuhoEDFw7rwNhYlQFVAXQCVZ2RMaznNQTB6TsYAZZWzEviIXMW4BgDOJbskI8pF-pVyTJ5m3eBy11mv21YPfdhnumvSGdzOBe0ztBbNELPeZgvfx9h_7TvMBuy2zvbe6WtyYbWPeHN6J-Tz5flj_pov3xdv89kyN1VVD-mWtpRgagENM0Ib26DQAq0A5FgD41NegWlszZCmkVZrXtoprDiVpZWWTcj9sXcT-u8txkG1Lhr0XnfYb6MSklW8EuJfkEopypLTBNIjaELaK6BVm-BaHfaKgjr4VWuV_KqDXwW1Sn5T5u5Uvl212PwmTkIT8HgEMLnYOQwqGoedwcaF5FE1vfuj_geUU4vw</recordid><startdate>20050121</startdate><enddate>20050121</enddate><creator>Wu, Ming-Jiuan</creator><creator>Weng, Ching-Yi</creator><creator>Ding, Hsiou-Yu</creator><creator>Wu, Pei-Jong</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20050121</creationdate><title>Anti-inflammatory and antiviral effects of Glossogyne tenuifolia</title><author>Wu, Ming-Jiuan ; Weng, Ching-Yi ; Ding, Hsiou-Yu ; Wu, Pei-Jong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-c47f270c860d3c6acfde6a6ef60e5e80359540cdf83e1ffefaa52f90b5172f7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Antiviral Agents - pharmacology</topic><topic>Cells, Cultured</topic><topic>Cytokines - biosynthesis</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>HBsAg</topic><topic>Hepatitis B Surface Antigens - biosynthesis</topic><topic>Hepatitis B virus</topic><topic>Humans</topic><topic>IFN-γ</topic><topic>IL-6</topic><topic>TNF-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Ming-Jiuan</creatorcontrib><creatorcontrib>Weng, Ching-Yi</creatorcontrib><creatorcontrib>Ding, Hsiou-Yu</creatorcontrib><creatorcontrib>Wu, Pei-Jong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Ming-Jiuan</au><au>Weng, Ching-Yi</au><au>Ding, Hsiou-Yu</au><au>Wu, Pei-Jong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-inflammatory and antiviral effects of Glossogyne tenuifolia</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2005-01-21</date><risdate>2005</risdate><volume>76</volume><issue>10</issue><spage>1135</spage><epage>1146</epage><pages>1135-1146</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Glossogyne tenuifolia (
Hsiang-Ju) is a traditional antipyretic and hepatoprotective herb used in Chinese medicine. The aim of this research is to investigate the pharmacological activities and potent components of the ethanol extract of
Glossogyne tenuifolia (GT) in human primary cells and cell line. We found that GT (0.1 ∼ 0.25 mg/ml) exerted dose-dependent inhibitions on the release of TNF-α and IL-6 in LPS-activated human whole blood and peripheral blood mononuclear cells (PBMC), and IFN-γ in PHA-stimulated human whole blood. The lack of cytotoxicity indicated that the inhibitory effects of GT on cytokine production were not due to cell death. Luteolin, the deglycosylated derivative of one of the major compositions, luteolin-7-glucoside, exerted inhibitory effects on TNF-α, IL-6 and IFN-γ production in activated human whole blood with estimated IC
50s of 42.73 μM, 44.86 μM and 3.34 μM, respectively. Furthermore, GT had potent anti-hepatitis B virus (HBV) effects on the human hepatocellular carcinoma cell line, PLC/PRF/5. GT exhibited a dose-dependent inhibition on the release of hepatitis B surface antigen (HBsAg) by repressing the expression of HBsAg with IC
50 of 0.093 mg/ml. We concluded that GT exerted combinatorial anti-inflammatory and antiviral effects, and the multiple actions may underlie its traditional hepatoprotective function.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>15620577</pmid><doi>10.1016/j.lfs.2004.08.017</doi><tpages>12</tpages></addata></record> |
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| subjects | Anti-Inflammatory Agents - pharmacology Antiviral Agents - pharmacology Cells, Cultured Cytokines - biosynthesis Dose-Response Relationship, Drug Drugs, Chinese Herbal - pharmacology HBsAg Hepatitis B Surface Antigens - biosynthesis Hepatitis B virus Humans IFN-γ IL-6 TNF-α |
| title | Anti-inflammatory and antiviral effects of Glossogyne tenuifolia |
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