Solubilization and Preformulation Studies on PG-300995 (An Anti-HIV Drug)

This study investigates the solubilization of a potential anti–human immunodeficiency virus agent [PG-300995 or 2-(2-thiophenyl)-4-azabenzoimidazole] for oral administration. The intrinsic solubility of PG-300995 is 51 μg/mL. Multiple approaches including combinations of pH control and cosolvency, m...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 2005-02, Vol.94 (2), p.297-303
Hauptverfasser:	Ran, Yingqing, Jain, Akash, Yalkowsky, Samuel H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - chemistry Benzimidazoles - chemistry Biological and medical sciences Buffers Chemistry, Pharmaceutical General pharmacology HIV - drug effects Human immunodeficiency virus Humans Hydrogen-Ion Concentration Ions Medical sciences Micelles Molecular Structure PG-300995 Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments preformulation Solubility solubilization
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!