Peripheral Polymorphonuclear Leukocyte Priming Contributes to Oxidative Stress in Early Pregnancy
Objective: The cause of elevated blood leukocyte count in pregnancy is unknown. We hypothesized that priming of peripheral polymorphonuclear leukocytes (PMNL) caused this elevation. Methods: Eleven women in the first trimester of pregnancy were included in this prospective study. Peripheral venous b...
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| Veröffentlicht in: | Journal of the Society for Gynecologic Investigation 2005-01, Vol.12 (1), p.46-49 |
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| container_title | Journal of the Society for Gynecologic Investigation |
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| creator | Fait, V. Sela, S. Ophir, E. Kreutzer, H. Shnaider, O. Perri, A. Khatib, N. Dourleshter, G. Tendler, R. Bornstein, J. |
| description | Objective: The cause of elevated blood leukocyte count in pregnancy is unknown. We hypothesized that priming of peripheral polymorphonuclear leukocytes (PMNL) caused this elevation.
Methods: Eleven women in the first trimester of pregnancy were included in this prospective study. Peripheral venous blood was drawn twice from each woman, before and after a medical abortion (pregnant and nonpregnant, respectively). Complete blood cell count, plasma alkaline phosphatase (ALP), and rate of superoxide release from separated phobrol 12-myristate-13-acetate (PMA)-stimulated PMNL were determined.
Results: The PMNL count in early pregnancy was significantly higher, with a signficant increase in the PMNL rate of superoxide release compared to the nonpregnant state. A linear correlation between the rates of superoxide release and PMNL counts before and during pregnancy was found. ALP levels were signftcantly elevated in early pregnancy.
Conclusion: The increased PMNL count is probably a compensatory response to PMNL priming. The increased rate of superoxide release from primed PMNL may contribute to oxidative stress in early pregnancy. |
| doi_str_mv | 10.1016/j.jsgi.2004.08.005 |
| format | Article |
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Methods: Eleven women in the first trimester of pregnancy were included in this prospective study. Peripheral venous blood was drawn twice from each woman, before and after a medical abortion (pregnant and nonpregnant, respectively). Complete blood cell count, plasma alkaline phosphatase (ALP), and rate of superoxide release from separated phobrol 12-myristate-13-acetate (PMA)-stimulated PMNL were determined.
Results: The PMNL count in early pregnancy was significantly higher, with a signficant increase in the PMNL rate of superoxide release compared to the nonpregnant state. A linear correlation between the rates of superoxide release and PMNL counts before and during pregnancy was found. ALP levels were signftcantly elevated in early pregnancy.
Conclusion: The increased PMNL count is probably a compensatory response to PMNL priming. The increased rate of superoxide release from primed PMNL may contribute to oxidative stress in early pregnancy.</description><identifier>ISSN: 1071-5576</identifier><identifier>EISSN: 1556-7117</identifier><identifier>DOI: 10.1016/j.jsgi.2004.08.005</identifier><identifier>PMID: 15629671</identifier><language>eng</language><publisher>Thousand Oaks, CA: Sage Publications</publisher><subject>Adult ; Alkaline Phosphatase - blood ; Biological and medical sciences ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Leukocyte Count ; Medical sciences ; Neutrophils - physiology ; Oxidative Stress ; Pregnancy - physiology ; Pregnancy Trimester, First ; Prospective Studies ; Superoxides</subject><ispartof>Journal of the Society for Gynecologic Investigation, 2005-01, Vol.12 (1), p.46-49</ispartof><rights>2005 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-5b9e208318e319f79ce0333caf1ac973ccb48be0f96a01840d980936a6fa9c3a3</citedby><cites>FETCH-LOGICAL-c371t-5b9e208318e319f79ce0333caf1ac973ccb48be0f96a01840d980936a6fa9c3a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1016/j.jsgi.2004.08.005$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1016/j.jsgi.2004.08.005$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,4024,21819,27923,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16807719$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15629671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fait, V.</creatorcontrib><creatorcontrib>Sela, S.</creatorcontrib><creatorcontrib>Ophir, E.</creatorcontrib><creatorcontrib>Kreutzer, H.</creatorcontrib><creatorcontrib>Shnaider, O.</creatorcontrib><creatorcontrib>Perri, A.</creatorcontrib><creatorcontrib>Khatib, N.</creatorcontrib><creatorcontrib>Dourleshter, G.</creatorcontrib><creatorcontrib>Tendler, R.</creatorcontrib><creatorcontrib>Bornstein, J.</creatorcontrib><title>Peripheral Polymorphonuclear Leukocyte Priming Contributes to Oxidative Stress in Early Pregnancy</title><title>Journal of the Society for Gynecologic Investigation</title><addtitle>J Soc Gynecol Investig</addtitle><description>Objective: The cause of elevated blood leukocyte count in pregnancy is unknown. We hypothesized that priming of peripheral polymorphonuclear leukocytes (PMNL) caused this elevation.
Methods: Eleven women in the first trimester of pregnancy were included in this prospective study. Peripheral venous blood was drawn twice from each woman, before and after a medical abortion (pregnant and nonpregnant, respectively). Complete blood cell count, plasma alkaline phosphatase (ALP), and rate of superoxide release from separated phobrol 12-myristate-13-acetate (PMA)-stimulated PMNL were determined.
Results: The PMNL count in early pregnancy was significantly higher, with a signficant increase in the PMNL rate of superoxide release compared to the nonpregnant state. A linear correlation between the rates of superoxide release and PMNL counts before and during pregnancy was found. ALP levels were signftcantly elevated in early pregnancy.
Conclusion: The increased PMNL count is probably a compensatory response to PMNL priming. The increased rate of superoxide release from primed PMNL may contribute to oxidative stress in early pregnancy.</description><subject>Adult</subject><subject>Alkaline Phosphatase - blood</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Leukocyte Count</subject><subject>Medical sciences</subject><subject>Neutrophils - physiology</subject><subject>Oxidative Stress</subject><subject>Pregnancy - physiology</subject><subject>Pregnancy Trimester, First</subject><subject>Prospective Studies</subject><subject>Superoxides</subject><issn>1071-5576</issn><issn>1556-7117</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2P0zAQhi0EYj_gD3BAvsAt2Zk6seMjqhZYqdJWAs6W4066Dmlc7GRF_j2uWmlvnGYOz_uO5mHsA0KJgPKuL_u09-UKoCqhKQHqV-wa61oWClG9zjsoLOpaySt2k1IPgCoH37IrrOVKS4XXzG4p-uMTRTvwbRiWQ4jHpzDObiAb-Ybm38EtE_Ft9Ac_7vk6jFP07TxR4lPgj3_9zk7-mfiPKVJK3I_83sZhyQHaj3Z0yzv2prNDoveXect-fb3_uf5ebB6_Pay_bAonFE5F3WpaQSOwIYG6U9oRCCGc7dA6rYRzbdW0BJ2WFrCpYKcb0EJa2VnthBW37PO59xjDn5nSZA4-ORoGO1KYk5FKVBVKmcHVGXQxpBSpM8f8nI2LQTAnsaY3J7HmJNZAY7LYHPp4aZ_bA-1eIheTGfh0AWxyduhi_t2nF042oBTqzN2duWT3ZPowxzFb-d_pf0o3kvE</recordid><startdate>200501</startdate><enddate>200501</enddate><creator>Fait, V.</creator><creator>Sela, S.</creator><creator>Ophir, E.</creator><creator>Kreutzer, H.</creator><creator>Shnaider, O.</creator><creator>Perri, A.</creator><creator>Khatib, N.</creator><creator>Dourleshter, G.</creator><creator>Tendler, R.</creator><creator>Bornstein, J.</creator><general>Sage Publications</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200501</creationdate><title>Peripheral Polymorphonuclear Leukocyte Priming Contributes to Oxidative Stress in Early Pregnancy</title><author>Fait, V. ; Sela, S. ; Ophir, E. ; Kreutzer, H. ; Shnaider, O. ; Perri, A. ; Khatib, N. ; Dourleshter, G. ; Tendler, R. ; Bornstein, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-5b9e208318e319f79ce0333caf1ac973ccb48be0f96a01840d980936a6fa9c3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Alkaline Phosphatase - blood</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Leukocyte Count</topic><topic>Medical sciences</topic><topic>Neutrophils - physiology</topic><topic>Oxidative Stress</topic><topic>Pregnancy - physiology</topic><topic>Pregnancy Trimester, First</topic><topic>Prospective Studies</topic><topic>Superoxides</topic><toplevel>online_resources</toplevel><creatorcontrib>Fait, V.</creatorcontrib><creatorcontrib>Sela, S.</creatorcontrib><creatorcontrib>Ophir, E.</creatorcontrib><creatorcontrib>Kreutzer, H.</creatorcontrib><creatorcontrib>Shnaider, O.</creatorcontrib><creatorcontrib>Perri, A.</creatorcontrib><creatorcontrib>Khatib, N.</creatorcontrib><creatorcontrib>Dourleshter, G.</creatorcontrib><creatorcontrib>Tendler, R.</creatorcontrib><creatorcontrib>Bornstein, J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the Society for Gynecologic Investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fait, V.</au><au>Sela, S.</au><au>Ophir, E.</au><au>Kreutzer, H.</au><au>Shnaider, O.</au><au>Perri, A.</au><au>Khatib, N.</au><au>Dourleshter, G.</au><au>Tendler, R.</au><au>Bornstein, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripheral Polymorphonuclear Leukocyte Priming Contributes to Oxidative Stress in Early Pregnancy</atitle><jtitle>Journal of the Society for Gynecologic Investigation</jtitle><addtitle>J Soc Gynecol Investig</addtitle><date>2005-01</date><risdate>2005</risdate><volume>12</volume><issue>1</issue><spage>46</spage><epage>49</epage><pages>46-49</pages><issn>1071-5576</issn><eissn>1556-7117</eissn><abstract>Objective: The cause of elevated blood leukocyte count in pregnancy is unknown. We hypothesized that priming of peripheral polymorphonuclear leukocytes (PMNL) caused this elevation.
Methods: Eleven women in the first trimester of pregnancy were included in this prospective study. Peripheral venous blood was drawn twice from each woman, before and after a medical abortion (pregnant and nonpregnant, respectively). Complete blood cell count, plasma alkaline phosphatase (ALP), and rate of superoxide release from separated phobrol 12-myristate-13-acetate (PMA)-stimulated PMNL were determined.
Results: The PMNL count in early pregnancy was significantly higher, with a signficant increase in the PMNL rate of superoxide release compared to the nonpregnant state. A linear correlation between the rates of superoxide release and PMNL counts before and during pregnancy was found. ALP levels were signftcantly elevated in early pregnancy.
Conclusion: The increased PMNL count is probably a compensatory response to PMNL priming. The increased rate of superoxide release from primed PMNL may contribute to oxidative stress in early pregnancy.</abstract><cop>Thousand Oaks, CA</cop><pub>Sage Publications</pub><pmid>15629671</pmid><doi>10.1016/j.jsgi.2004.08.005</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Alkaline Phosphatase - blood Biological and medical sciences Female Gynecology. Andrology. Obstetrics Humans Leukocyte Count Medical sciences Neutrophils - physiology Oxidative Stress Pregnancy - physiology Pregnancy Trimester, First Prospective Studies Superoxides |
| title | Peripheral Polymorphonuclear Leukocyte Priming Contributes to Oxidative Stress in Early Pregnancy |
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