C‐Met overexpression in node‐positive breast cancer identifies patients with poor clinical outcome independent of Her2/neu

Receptor tyrosine kinases play an important role in malignant transformation of epithelial cells by activating signal transduction pathways important for proliferation, invasion and metastasis. In a pilot study (n = 40), we evaluated expression of the c‐Met and Her2/neu receptor tyrosine kinases and...

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Veröffentlicht in:	International journal of cancer 2005-02, Vol.113 (4), p.678-682
Hauptverfasser:	Lengyel, Ernst, Prechtel, Dieter, Resau, James H., Gauger, Katja, Welk, Anita, Lindemann, Kristina, Salanti, Georgia, Richter, Thomas, Knudsen, Beatrice, Vande Woude, George F., Harbeck, Nadia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology c‐Met Disease Progression Disease-Free Survival Female Fibrocystic Breast Disease - drug therapy Fibrocystic Breast Disease - metabolism Fibrocystic Breast Disease - pathology Gynecology. Andrology. Obstetrics hepatocyte growth factor Hepatocyte Growth Factor - metabolism Her2/neu Humans Hyperplasia - drug therapy Hyperplasia - metabolism Hyperplasia - pathology Ligands Lymph Nodes - pathology Lymphatic Metastasis - pathology Mammary gland diseases Medical sciences Middle Aged Neoplasm Staging Pilot Projects Proto-Oncogene Proteins c-met - metabolism receptor tyrosine kinase Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Risk Factors Survival Rate Treatment Outcome Tumors
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