Toll‐like receptor 6‐independent signaling by diacylated lipopeptides

Bacterial lipopeptides are strong immune modulators that activate early host responses after infection as well as initiating adjuvant effects on the adaptive immune system. These lipopeptides induce signaling in cells of the immune system through Toll‐like receptor 2 (TLR2)–TLR1 or TLR2–TLR6 heterom...

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Veröffentlicht in:	European journal of immunology 2005-01, Vol.35 (1), p.282-289
Hauptverfasser:	Buwitt‐Beckmann, Ute, Heine, Holger, Wiesmüller, Karl‐Heinz, Jung, Günther, Brock, Roland, Akira, Shizuo, Ulmer, Artur J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals B-Lymphocytes - drug effects B-Lymphocytes - immunology Bacterial lipopeptides Diglycerides - chemistry Diglycerides - immunology Diglycerides - pharmacology Immunity, Innate Immunologic Factors - chemistry Immunologic Factors - immunology Immunologic Factors - pharmacology In Vitro Techniques Knockout mice Lipoproteins - chemistry Lipoproteins - immunology Lipoproteins - pharmacology Macrophages - drug effects Macrophages - immunology Membrane Glycoproteins - deficiency Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Molecular Sequence Data Molecular Structure Mycoplasma fermentans Receptors, Cell Surface - deficiency Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Rhodopseudomonas - chemistry Rhodopseudomonas - immunology Signal Transduction Toll-Like Receptor 2 Toll-Like Receptor 6 Tumor Necrosis Factor-alpha - biosynthesis
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